Abstract
A systematic approach was used to review, elucidate and summarize the importance of phytochemicals and essential oils (EO) as substitutes for chemical feed additives in ruminant feeding. Using PRISMA statement for defined search strategy, screening, selection and obtaining reliable conclusions, only articles that met the predefined selection criteria were used for the review. Phytochemicals feed additives (PFA) contain EO and a lot of other plant secondary metabolites (PSM). Essential oils are volatile aromatic compounds in most cases, and they compose of terpenoids and phenylpropanoids, which have antimicrobial properties. They have been the subject of persistent consideration of animal nutritionists who have been evaluating their use as feed additives to enhance ruminal fermentation and feed utilization efficiency. As alternatives to non-nutritive chemical and antibiotic feed additives, many phytochemicals (i.e. PSM), from a broad spectrum of herbs and spices, have been used to modify ruminal fermentation characteristics, inhibit ruminal methanogenesis and enhance livestock performance. The main limitations of PFA are defining the optimal doses that enhance animal performance and the adaptation of ruminal microflora to their presence in diets, resulting in inconsistent and inconclusive results. Many factors affecting the effective dose of phytochemicals include the chemical structures of phytochemical supplements/additives, the animal diet and animal physiological status. This review illustrates the possibility of using PFA on ruminal microbiota and their adaptation to phytochemicals, ruminal fermentation and animal performance.
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References
Abd El Tawab AM, Kholif AE, Khattab MSA et al (2020) Feed utilization and lactational performance of Barki sheep fed diets containing thyme or celery. Small Rumin Res 192:106249. https://doi.org/10.1016/j.smallrumres.2020.106249
Agarwal N, Shekhar C, Kumar R et al (2009) Effect of peppermint (Mentha piperita) oil on in vitro methanogenesis and fermentation of feed with buffalo rumen liquor. Anim Feed Sci Technol 148:321–327. https://doi.org/10.1016/j.anifeedsci.2008.04.004
Bampidis VA, Christodoulou V, Florou-Paneri P et al (2005) Effect of dietary dried oregano leaves supplementation on performance and carcass characteristics of growing lambs. Anim Feed Sci Technol 121:285–295. https://doi.org/10.1016/j.anifeedsci.2005.02.002
Beauchemin KA, McGinn SM (2006) Methane emissions from beef cattle: Effects of fumaric acid, essential oil, and canola oil. J Anim Sci 84:1489–1496. https://doi.org/10.2527/2006.8461489x
Benchaar C, Chouinard PY (2009) Short communication: Assessment of the potential of cinnamaldehyde, condensed tannins, and saponins to modify milk fatty acid composition of dairy cows. J Dairy Sci 92:3392–3396. https://doi.org/10.3168/jds.2009-2111
Benchaar C, Duynisveld JL, Charmley E (2006) Effects of monensin and increasing dose levels of a mixture of essential oil compounds on intake, digestion and growth performance of beef cattle. Can J Anim Sci 86:91–96. https://doi.org/10.4141/A05-027
Benchaar C, Petit HV, Berthiaume R et al (2007b) Effects of essential oils on digestion, ruminai fermentation, rumen microbial populations, milk production, and milk composition in dairy cows fed alfalfa silage or corn silage. J Dairy Sci 90:886–897. https://doi.org/10.3168/jds.S0022-0302(07)71572-2
Benchaar C, Chaves AV, Fraser GR et al (2007a) Effects of essential oils and their components on in vitro rumen microbial fermentation. Can J Anim Sci 87:413–419. https://doi.org/10.4141/CJAS07012
Benchaar C, Calsamiglia S, Chaves AV et al (2008) A review of plant-derived essential oils in ruminant nutrition and production. Anim Feed Sci Technol 145:209–228. https://doi.org/10.1016/j.anifeedsci.2007.04.014
Bodas R, López S, Fernández M et al (2008) In vitro screening of the potential of numerous plant species as antimethanogenic feed additives for ruminants. Anim Feed Sci Technol 145:245–258. https://doi.org/10.1016/j.anifeedsci.2007.04.015
Bodas R, Prieto N, García-González R et al (2012) Manipulation of rumen fermentation and methane production with plant secondary metabolites. Anim Feed Sci Technol 176:78–93. https://doi.org/10.1016/j.anifeedsci.2012.07.010
Borugă O, Jianu C, Mişcă C et al (2014) Thymus vulgaris essential oil: chemical composition and antimicrobial activity. J Med Life 7(3):56–60
Busquet M, Calsamiglia S, Ferret A et al (2005) Effects of cinnamaldehyde and garlic oil on rumen microbial fermentation in a dual flow continuous culture. J Dairy Sci 88:2508–2516. https://doi.org/10.3168/jds.S0022-0302(05)72928-3
Calsamiglia S, Busquet M, Cardozo PW et al (2007) Invited review: Essential oils as modifiers of rumen microbial fermentation. J Dairy Sci 90:2580–2595. https://doi.org/10.3168/jds.2006-644
Cardozo PW, Calsamiglia S, Ferret A, Kamel C (2005) Screening for the effects of natural plant extracts at different pH on in vitro rumen microbial fermentation of a high-concentrate diet for beef cattle. J Anim Sci 83:2572–2579. https://doi.org/10.2527/2005.83112572x
Cardozo PW, Calsamiglia S, Ferret A, Kamel C (2006) Effects of alfalfa extract, anise, capsicum, and a mixture of cinnamaldehyde and eugenol on ruminal fermentation and protein degradation in beef heifers fed a high-concentrate diet. J Anim Sci 84:2801–2808. https://doi.org/10.2527/jas.2005-593
Castillejos L, Calsamiglia S, Ferret A (2006) Effect of essential oil active compounds on rumen microbial fermentation and nutrient flow in in vitro systems. J Dairy Sci 89:2649–2658. https://doi.org/10.3168/jds.S0022-0302(06)72341-4
Castro-Montoya JM, Makkar HPS, Becker K (2011) Chemical composition of rumen microbial fraction and fermentation parameters as affected by tannins and saponins using an in vitro rumen fermentation system. Can J Anim Sci 91:433–448. https://doi.org/10.4141/CJAS2010-028
Cedillo J, Vázquez-Armijo JF, González-Reyna A et al (2014) Effects of different doses of Salix babylonica extract on growth performance and diet in vitro gas production in Pelibuey growing lambs. Ital J Anim Sci 13:609–613. https://doi.org/10.4081/ijas.2014.3165
Cedillo J, Kholif AE, Salem AZM et al (2015) Oral administration of Sauce llorón extract to growing lambs to control gastrointestinal nematodes and Moniezia spp. Asian Pac J Trop Med 8:520–525. https://doi.org/10.1016/j.apjtm.2015.06.011
Chaves AV, Stanford K, Gibson LL et al (2008c) Effects of carvacrol and cinnamaldehyde on intake, rumen fermentation, growth performance, and carcass characteristics of growing lambs. Anim Feed Sci Technol 145:396–408. https://doi.org/10.1016/j.anifeedsci.2007.04.016
Chaves AV, Stanford K, Dugan MER et al (2008b) Effects of cinnamaldehyde, garlic and juniper berry essential oils on rumen fermentation, blood metabolites, growth performance, and carcass characteristics of growing lambs. Livest Sci 117:215–224. https://doi.org/10.1016/j.livsci.2007.12.013
Chaves AV, He ML, Yang WZ et al (2008a) Effects of essential oils on proteolytic, deaminative and methanogenic activities of mixed ruminal bacteria. Can J Anim Sci 88:117–122. https://doi.org/10.4141/CJAS07061
Ebeid HM, Kholif AE, Chrenkova M, Anele UY (2020a) Ruminal fermentation kinetics of Moringa oleifera leaf and seed as protein feeds in dairy cow diets: in sacco degradability and protein and fiber fractions assessed by the CNCPS method. Agrofor Syst 94:905–915. https://doi.org/10.1007/s10457-019-00456-7
Ebeid HM, Mengwei L, Kholif AE et al (2020b) Moringa oleifera oil modulates rumen microflora to mediate in vitro fermentation kinetics and methanogenesis in total mix rations. Curr Microbiol 77:1271–1282. https://doi.org/10.1007/s00284-020-01935-2
Elghalid OA, Kholif AE, El-Ashry GM et al (2020) Oral supplementation of the diet of growing rabbits with a newly developed mixture of herbal plants and spices enriched with special extracts and essential oils affects their productive performance and immune status. Livest Sci 238:104082. https://doi.org/10.1016/j.livsci.2020.104082
Elghangour MMY, Kholif AE, Bastida AZ et al (2015) In vitro gas production of five rations of different maize silage and concentrate ratios influenced by increasing levels of chemically characterized extract of Salix babylonica. Turkish J Vet Anim Sci 39:186–194. https://doi.org/10.3906/vet-1408-62
El-Zaiat HM, Kholif AE, Moharam MS et al (2020) The ability of tanniniferous legumes to reduce methane production and enhance feed utilization in Barki rams: in vitro and in vivo evaluation. Small Rumin Res 193:106259. https://doi.org/10.1016/j.smallrumres.2020.106259
Evans JD, Martin SA (2000) Effects of thymol on ruminal microorganisms. Curr Microbiol 41:336–340. https://doi.org/10.1007/s002840010145
Fraser GR, Chaves AV, Wang Y et al (2007) Assessment of the effects of cinnamon leaf oil on rumen microbial fermentation using two continuous culture systems. J Dairy Sci 90:2315–2328. https://doi.org/10.3168/jds.2006-688
Ghazy OA, Fouad MT, Saleh HH et al (2021) Ultrasound-assisted preparation of anise extract nanoemulsion and its bioactivity against different pathogenic bacteria. Food Chem. 341:128259. https://doi.org/10.1016/j.foodchem.2020.128259
Goel G, Makkar HPS (2012) Methane mitigation from ruminants using tannins and saponins. Trop Anim Health Prod 44:729–739. https://doi.org/10.1007/s11250-011-9966-2
Goel G, Makkar HPS, Becker K (2008) Effects of Sesbania sesban and Carduus pycnocephalus leaves and Fenugreek (Trigonella foenum-graecum L.) seeds and their extracts on partitioning of nutrients from roughage- and concentrate-based feeds to methane. Anim Feed Sci Technol 147:72–89. https://doi.org/10.1016/j.anifeedsci.2007.09.010
Abu Hafsa SH, Salem AZM, Hassan AA et al (2016) Digestion, growth performance and caecal fermentation in growing rabbits fed diets containing foliage of browse trees. World Rabbit Sci 24:283–293. https://doi.org/10.4995/wrs.2016.4359
Hart KJ, Yáñez-Ruiz DR, Duval SM et al (2008) Plant extracts to manipulate rumen fermentation. Anim Feed Sci Technol 147:8–35. https://doi.org/10.1016/j.anifeedsci.2007.09.007
Headon DR, Buggle K, Nelson A, Killeen G (1991) Glycofractions of the Yucca plant and their role in ammonia control. In: Lyons TP (ed) Biotechnology in the Feed Industry. Alltech Technical Publications, Nicholasville, pp 95–108
Helander IM, Alakomi HL, Latva-Kala K et al (1998) Characterization of the action of selected essential oil components on gram-negative bacteria. J Agric Food Chem 46:3590–3595. https://doi.org/10.1021/jf980154m
Hernandez A, Kholif AE, Lugo-Coyote R et al (2017) The effect of garlic oil, xylanase enzyme and yeast on biomethane and carbon dioxide production from 60-d old Holstein dairy calves fed a high concentrate diet. J Clean Prod 142:2384–2392. https://doi.org/10.1016/j.jclepro.2016.11.036
Jouany JP, Morgavi DP (2007) Use of “natural” products as alternatives to antibiotic feed additives in ruminant production. Animal 1:1443–1466. https://doi.org/10.1017/S1751731107000742
Khattab MSA, Kholif AE, Abd El Tawab AM et al (2020) Effect of replacement of antibiotics with thyme and celery seed mixture on the feed intake and digestion, ruminal fermentation, blood chemistry, and milk lactation of lactating Barki ewes. Food Funct 11:6889–6898. https://doi.org/10.1039/d0fo00807a
Khiaosa-Ard R, Zebeli Q (2013) Meta-analysis of the effects of essential oils and their bioactive compounds on rumen fermentation characteristics and feed efficiency in ruminants. J Anim Sci 91:1819–1830. https://doi.org/10.2527/jas.2012-5691
Kholif AE, Gouda GA, Morsy TA et al (2015) Moringa oleifera leaf meal as a protein source in lactating goat’s diets: feed intake, digestibility, ruminal fermentation, milk yield and composition, and its fatty acids profile. Small Rumin Res 129:129–137. https://doi.org/10.1016/j.smallrumres.2015.05.007
Kholif AE, Morsy TA, Gouda GA et al (2016) Effect of feeding diets with processed Moringa oleifera meal as protein source in lactating Anglo-Nubian goats. Anim Feed Sci Technol 217:45–55. https://doi.org/10.1016/j.anifeedsci.2016.04.012
Kholif AE, Matloup OH, Morsy TA et al (2017) Rosemary and lemongrass herbs as phytogenic feed additives to improve efficient feed utilization, manipulate rumen fermentation and elevate milk production of Damascus goats. Livest Sci 204:39–46. https://doi.org/10.1016/j.livsci.2017.08.001
Kholif AE, Kassab AY, Azzaz HH et al (2018c) Essential oils blend with a newly developed enzyme cocktail works synergistically to enhance feed utilization and milk production of Farafra ewes in the subtropics. Small Rumin Res 161:43–50. https://doi.org/10.1016/j.smallrumres.2018.02.011
Kholif AE, Gouda GA, Anele UY, Galyean ML (2018a) Extract of Moringa oleifera leaves improves feed utilization of lactating Nubian goats. Small Rumin Res 158:69–75. https://doi.org/10.1016/j.smallrumres.2017.10.014
Kholif AE, Gouda GA, Olafadehan OA, Abdo MM (2018b) Effects of replacement of Moringa oleifera for berseem clover in the diets of Nubian goats on feed utilisation, and milk yield, composition and fatty acid profile. Animal 12:964–972. https://doi.org/10.1017/S1751731117002336
Kholif AE, Gouda GA, Galyean ML et al (2019) Extract of Moringa oleifera leaves increases milk production and enhances milk fatty acid profile of Nubian goats. Agrofor Syst 93:1877–1886. https://doi.org/10.1007/s10457-018-0292-9
Kholif AE, Hassan AA, El Ashry GM et al (2021a) Phytogenic feed additives mixture enhances the lactational performance, feed utilization and ruminal fermentation of Friesian cows. Anim Biotechnol. https://doi.org/10.1080/10495398.2020.1746322
Kholif AE, Hassan AA, Matloup OH, El Ashry GM (2021b) Top-dressing of chelated phytogenic feed additives in the diet of lactating Friesian cows to enhance feed utilization and lactational performance. Ann Anim Sci. https://doi.org/10.2478/aoas-2020-0086
Kim H, Jung E, Lee HG et al (2019) Essential oil mixture on rumen fermentation and microbial community - An in vitro study. Asian-Australasian J Anim Sci 32:808–814. https://doi.org/10.5713/ajas.18.0652
Klop G, Van Laar-Van SS, Pellikaan WF et al (2017) Changes in in vitro gas and methane production from rumen fluid from dairy cows during adaptation to feed additives in vivo. Animal 11:591–599. https://doi.org/10.1017/S1751731116002019
Liberati A, Altman DG, Tetzlaff J et al (2009) The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate healthcare interventions: explanation and elaboration. BMJ 339:b2700–b2700. https://doi.org/10.1136/bmj.b2700
Lourenço M, Cardozo PW, Calsamiglia S, Fievez V (2008) Effects of saponins, quercetin, eugenol, and cinnamaldehyde on fatty acid biohydrogenation of forage polyunsaturated fatty acids in dual-flow continuous culture fermenters. J Anim Sci 86:3045–3053. https://doi.org/10.2527/jas.2007-0708
Macheboeuf D, Morgavi DP, Papon Y et al (2008) Dose-response effects of essential oils on in vitro fermentation activity of the rumen microbial population. Anim Feed Sci Technol 145:335–350. https://doi.org/10.1016/j.anifeedsci.2007.05.044
Malecky M, Broudiscou LP, Schmidely P (2009) Effects of two levels of monoterpene blend on rumen fermentation, terpene and nutrient flows in the duodenum and milk production in dairy goats. Anim Feed Sci Technol 154:24–35. https://doi.org/10.1016/j.anifeedsci.2009.07.004
Matloup OH, Abd El Tawab AM, Hassan AA et al (2017) Performance of lactating Friesian cows fed a diet supplemented with coriander oil: Feed intake, nutrient digestibility, ruminal fermentation, blood chemistry, and milk production. Anim Feed Sci Technol 226:88–97. https://doi.org/10.1016/j.anifeedsci.2017.02.012
Mbiriri DT, Cho S, Mamvura CI, Choi NJ (2016) Assessment of rumen microbial adaptation to garlic oil, carvacrol and thymol using the consecutive batch culture system. J Vet Sci Anim Husb 4:1–7. https://doi.org/10.15744/2348-9790.4.101
McIntosh FM, Williams P, Losa R et al (2003) Effects of essential oils on ruminal microorganisms and their protein metabolism. Appl Environ Microbiol 69:5011–5014. https://doi.org/10.1128/AEM.69.8.5011-5014.2003
McSweeney CS, Palmer B, Bunch R, Krause DO (2001) Effect of the tropical forage calliandra on microbial protein synthesis and ecology in the rumen. J Appl Microbiol 90:78–88. https://doi.org/10.1046/j.1365-2672.2001.01220.x
Moher D, Liberati A, Tetzlaff J et al (2009) Preferred reporting items for systematic reviews and meta-analyses: The PRISMA statement. PLoS Med 6:e1000097. https://doi.org/10.1371/journal.pmed.1000097
Monteny GJ, Bannink A, Chadwick D (2006) Greenhouse gas abatement strategies for animal husbandry. Agric Ecosyst Environ 112:163–170. https://doi.org/10.1016/j.agee.2005.08.015
Morsy TA, Kholif AE, Matloup OH et al (2018) Mustard and cumin seeds improve feed utilisation, milk production and milk fatty acids of Damascus goats. J Dairy Res 85:142–151. https://doi.org/10.1017/S0022029918000043
Newbold C, El Hassan SM, Wang J et al (1997) Influence of foliage from African multipurpose trees on activity of rumen protozoa and bacteria. Br J Nutr 78:237–249. https://doi.org/10.1079/bjn19970143
Newbold CJ, McIntosh FM, Williams P et al (2004) Effects of a specific blend of essential oil compounds on rumen fermentation. Anim Feed Sci Technol 114:105–112. https://doi.org/10.1016/j.anifeedsci.2003.12.006
Nikaido H (1994) Prevention of drug access to bacterial targets: Permeability barriers and active efflux. Science 264(80):382–388. https://doi.org/10.1126/science.8153625
Patra AK (2011) Effects of essential oils on rumen fermentation, microbial ecology and ruminant production. Asian J Anim Vet Adv 6:416–428. https://doi.org/10.3923/ajava.2011.416.428
Patra AK, Saxena J (2009b) Dietary phytochemicals as rumen modifiers: A review of the effects on microbial populations. Antonie van Leeuwenhoek, Int J Gen Mol Microbiol 96:363–375. https://doi.org/10.1007/s10482-009-9364-1
Patra AK, Saxena J (2009a) The effect and mode of action of saponins on the microbial populations and fermentation in the rumen and ruminant production. Nutr Res Rev 22:204–219. https://doi.org/10.1017/S0954422409990163
Patra AK, Saxena J (2010) A new perspective on the use of plant secondary metabolites to inhibit methanogenesis in the rumen. Phytochemistry 71:1198–1222. https://doi.org/10.1016/j.phytochem.2010.05.010
Patra AK, Saxena J (2011) Exploitation of dietary tannins to improve rumen metabolism and ruminant nutrition. J Sci Food Agric 91:24–37. https://doi.org/10.1002/jsfa.4152
Patra AK, Kamra DN, Agarwal N (2010) Effects of extracts of spices on rumen methanogenesis, enzyme activities and fermentation of feeds in vitro. J Sci Food Agric 90:511–520. https://doi.org/10.1002/jsfa.3849
Pawar MM, Kamra DN, Agarwal N, Chaudhary LC (2014) Effects of essential oils on in vitro methanogenesis and feed fermentation with buffalo rumen liquor. Agric Res 3:67–74. https://doi.org/10.1007/s40003-014-0092-z
Rivero N, Salem AZM, Ayala M et al (2016) Influence of Salix babylonica extract, exogenous enzyme of xylanase and their combination on blood haematological and biochemical profile in sheep and goats. Indian J Anim Sci 86:1140–1144. https://doi.org/10.18805/ijar.8601
Salem AZM, Kholif AE, Elghangour MMY et al (2014a) Effect of increasing levels of seven tree species extracts added to a high concentrate diet on in vitro rumen gas output. Anim Sci J 85:853–860. https://doi.org/10.1111/asj.12218
Salem AZM, Kholif AE, Elghangour MMY et al (2014b) Influence of oral administration of Salix babylonica extract on milk production and composition in dairy cows. Ital J Anim Sci 13:10–14. https://doi.org/10.4081/ijas.2014.2978
Salem AZM, Kholif AE, Olivares M et al (2014c) Influence of S. babylonica extract on feed intake, growth performance and diet in vitro gas production profile in young lambs. Trop Anim Health Prod 46:213–219. https://doi.org/10.1007/s11250-013-0478-0
Salem AZM, Ryena AG, Elghangour MMY et al (2014d) Influence of Salix babylonica extract in combination or not with increasing levels of minerals mixture on in vitro rumen gas production kinetics of a total mixed ration. Ital J Anim Sci 13:873–879. https://doi.org/10.4081/ijas.2014.3110
Salem AZM, Kholif AE, Elghangour MMY et al (2016) Influence of Salix babylonica extract addition on in vitro rumen gas production and degradability of ryegrass silage harvested in different cutting days. Indian J Anim Sci 86:1030–1035
Salem AZM, Elghangour MMY, Kholif AE et al (2017) Tree leaves of Salix babylonica extract as a natural anthelmintic for small-ruminant farms in a semiarid region in Mexico. Agrofor Syst 91:111–122. https://doi.org/10.1007/s10457-016-9909-z
Santos MB, Robinson PH, Williams P, Losa R (2010) Effects of addition of an essential oil complex to the diet of lactating dairy cows on whole tract digestion of nutrients and productive performance. Anim Feed Sci Technol 157:64–71. https://doi.org/10.1016/j.anifeedsci.2010.02.001
Simitzis PE (2017) Enrichment of animal diets with essential oils—a great perspective on improving animal performance and quality characteristics of the derived products. Medicines 4:35. https://doi.org/10.3390/medicines4020035
Smith AH, Zoetendal E, Mackie RI (2005) Bacterial mechanisms to overcome inhibitory effects of dietary tannins. Microb Ecol 50:197–205
Soltan YA, Natel AS, Araujo RC et al (2018) Progressive adaptation of sheep to a microencapsulated blend of essential oils: Ruminal fermentation, methane emission, nutrient digestibility, and microbial protein synthesis. Anim Feed Sci Technol 237:8–18. https://doi.org/10.1016/j.anifeedsci.2018.01.004
Spanghero M, Zanfi C, Fabbro E et al (2008) Effects of a blend of essential oils on some end products of in vitro rumen fermentation. Anim Feed Sci Technol 145:364–374. https://doi.org/10.1016/j.anifeedsci.2007.05.048
Staerfl SM, Kreuzer M, Soliva CR (2010) In vitro screening of unconventional feeds and various natural supplements for their ruminai methane mitigation potential when included in a maize-silage based diet. J Anim Feed Sci 19:651–664 https://doi.org/10.22358/jafs/66338/2010
Stevanović ZD, Bošnjak-Neumüller J, Pajić-Lijaković I et al (2018) Essential oils as feed additives—Future perspectives. Molecules 23:1717. https://doi.org/10.3390/molecules23071717
Stewart CS, Flint HJ, Bryant MP (1997) The rumen bacteria. In: Hobson PN, Stewart CS (eds) The Rumen Microbial Ecosystem. Blackie Academic and Professional, New York, pp 10–72
Tan HY, Sieo CC, Abdullah N et al (2011) Effects of condensed tannins from Leucaena on methane production, rumen fermentation and populations of methanogens and protozoa in vitro. Anim Feed Sci Technol 169:185–193. https://doi.org/10.1016/j.anifeedsci.2011.07.004
Tassoul MD, Shaver RD (2009) Effect of a mixture of supplemental dietary plant essential oils on performance of periparturient and early lactation dairy cows. J Dairy Sci 92:1734–1740. https://doi.org/10.3168/jds.2008-1760
Valdes KI, Salem AZM, Lopez S et al (2015) Influence of exogenous enzymes in presence of Salix babylonica extract on digestibility, microbial protein synthesis and performance of lambs fed maize silage. J Agric Sci 153:732–742. https://doi.org/10.1017/S0021859614000975
Wallace RJ (2004) Antimicrobial properties of plant secondary metabolites. Proc Nutr Soc 63:621–629. https://doi.org/10.1079/pns2004393
Wallace RJ, McEwan NR, McIntosh FM et al (2002) Natural products as manipulators of rumen fermentation. Asian-Australasian J Anim Sci 15:1458–1468. https://doi.org/10.5713/ajas.2002.1458
Wang CJ, Wang SP, Zhou H (2009) Influences of flavomycin, ropadiar, and saponin on nutrient digestibility, rumen fermentation, and methane emission from sheep. Anim Feed Sci Technol 148:157–166. https://doi.org/10.1016/j.anifeedsci.2008.03.008
Wina E, Muetzel S, Hoffmann E et al (2005) Saponins containing methanol extract of Sapindus rarak affect microbial fermentation, microbial activity and microbial community structure in vitro. Anim Feed Sci Technol 121:159–174. https://doi.org/10.1016/j.anifeedsci.2005.02.016
Yang WZ, Benchaar C, Ametaj BN et al (2007) Effects of garlic and juniper berry essential oils on ruminal fermentation and on the site and extent of digestion in lactating cows. J Dairy Sci 90:5671–5681. https://doi.org/10.3168/jds.2007-0369
Yang WZ, Ametaj BN, Benchaar C, Beauchemin KA (2010) Dose response to cinnamaldehyde supplementation in growing beef heifers: Ruminal and intestinal digestion. J Anim Sci 88:680–688. https://doi.org/10.2527/jas.2008-1652
Zhou R, Wu J, Zhang L et al (2019) Effects of oregano essential oil on the ruminal pH and microbial population of sheep. PLoS ONE 14:e0217054. https://doi.org/10.1371/journal.pone.0217054
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Kholif, A.E., Olafadehan, O.A. Essential oils and phytogenic feed additives in ruminant diet: chemistry, ruminal microbiota and fermentation, feed utilization and productive performance. Phytochem Rev 20, 1087–1108 (2021). https://doi.org/10.1007/s11101-021-09739-3
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DOI: https://doi.org/10.1007/s11101-021-09739-3