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Plasma Processing of Scaffolds for Tissue Engineering and Regenerative Medicine

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Abstract

Plasma processes are largely employed in the biomedical field for different kind of materials. In particular, in tissue engineering, biomaterials need to be totally integrated with biological systems in order to be employed as substitutes of artificial prostheses. Since most materials do not allow a correct integration with the biological environment, plasma processes have been demonstrated to be very versatile in altering the material surface properties in order to improve the biocompatibility of materials. The challenge is to plasma modify 3D scaffolds in order to be used for in vivo regeneration of human tissues. The correct 3D biointegration inside living tissues is the crucial objective, towards which many aspects are directed, from the material engineering to its surface modification and affinity with the biological environment. In this paper, the advances in low pressure plasma processes, applied to both 2D rigid substrates and 3D porous structures, are discussed. Further an in vivo experiment in ovine animals using plasma processed 3D scaffolds is illustrated.

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Acknowledgments

The following projects are acknowledged for funding and supporting this research: RIGENERA (Aiuti a Sostegno dei Partenariati Regionali per l’Innovazione, no. P9Y0834); RINOVATIS (Regenerating Nervous and Osteocartilagineous Tissues by Means of Innovative Tissue Engineering Approaches, PON 02_00563_3448479); LIPP (Rete di Laboratorio 51, Regione Puglia); SISTEMA (PONa3_00369 MIUR, Laboratorio per lo Sviluppo Integrato delle Scienze e delle TEcnologie dei Materiali Avanzati e per dispositivi innovativi). Ms. Edda Giuseppina Francioso (University of Bari), Mr. Savino Cosmai (IMIP-CNR) and Mr. Danilo Benedetti (University of Bari) are acknowledged for technical support.

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Authors and Affiliations

  1. Department of Chemistry, University of Bari, Bari, Italy

    F. Intranuovo & P. Favia

  2. NANOTEC Institute, National Research Council, Bari, Italy

    R. Gristina & P. Favia

  3. Veterinary Surgery, Department Emergency and Organ Transplantation, University of Bari, Bari, Italy

    L. Fracassi, L. Lacitignola & A. Crovace

Authors
  1. F. Intranuovo
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  2. R. Gristina
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  3. L. Fracassi
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  4. L. Lacitignola
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  5. A. Crovace
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  6. P. Favia
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Corresponding author

Correspondence to F. Intranuovo.

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Intranuovo, F., Gristina, R., Fracassi, L. et al. Plasma Processing of Scaffolds for Tissue Engineering and Regenerative Medicine. Plasma Chem Plasma Process 36, 269–280 (2016). https://doi.org/10.1007/s11090-015-9667-0

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  • DOI: https://doi.org/10.1007/s11090-015-9667-0

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