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FDG-PET Contributions to the Pathophysiology of Memory Impairment

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Abstract

Measurement of synaptic activity by Positron Emission Tomography (PET) and its relation to cognitive functions such as episodic memory, working memory and executive functions in healthy humans and patients with neurocognitive disorders have been well documented. In this review, we introduce the concept of PET imaging that allows the observation of a particular biological process in vivo through the use of radio-labelled compounds, its general use to the medical world and its contributions to the understanding of memory systems. We then focus on [18F]-2-fluoro-2-deoxy-D-glucose (FDG-PET), the radiotracer that is used to measure local cerebral metabolic rate of glucose that is indicative of synaptic activity in the brain. FDG-PET at rest has been at the forefront of functional neuroimaging over the past 3 decades, contributing to the understanding of cognitive functions in healthy humans and how these functional patterns change with cognitive alterations. We discuss methodological considerations that are important for optimizing FDG-PET imaging data prior to analysis. We then highlight the contribution of FDG-PET to the understanding of the patterns of functional differences in non-degenerative pathologies, normal ageing, and age-related neurodegenerative disorders. Through reasonable temporal and spatial resolution, its ability to measure synaptic activity in the whole brain, independently of any specific network and disease, makes it ideal to observe regional functional changes associated with memory impairment.

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Abbreviations

AD:

Alzheimer’s disease

ADNI:

Alzheimer’s Disease Neuroimaging Initiative

CBF:

Cerebral Blood Flow

FDG:

[18F]-2-fluoro-2-deoxy-D-glucose

FOV:

Field of view

FTD:

Frontotemporal dementia

FWHM:

Full-width-half-maximum

lCMRglc:

Local cerebral metabolic rate of glucose

KS:

Korsakoff’s syndrome

MCI:

Mild Cognitive Impairment

MRI:

Magnetic Resonance Imaging

MTL:

Medial Temporal Lobe

PET:

Positron Emission Tomography

PSF:

Point spread function

PVC:

Partial volume correction

PVE:

Partial volume effects

VOI:

Volume of interest

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  1. Inserm, U1077, Caen, France

    Shailendra Segobin, Renaud La Joie, Ludivine Ritz, Hélène Beaunieux, Béatrice Desgranges, Gaël Chételat, Anne Lise Pitel & Francis Eustache

  2. Université de Caen Normandie, UMR-S1077, Caen, France

    Shailendra Segobin, Renaud La Joie, Ludivine Ritz, Hélène Beaunieux, Béatrice Desgranges, Gaël Chételat, Anne Lise Pitel & Francis Eustache

  3. Ecole Pratique des Hautes Etudes, UMR-S1077, Caen, France

    Shailendra Segobin, Renaud La Joie, Ludivine Ritz, Hélène Beaunieux, Béatrice Desgranges, Gaël Chételat, Anne Lise Pitel & Francis Eustache

  4. Centre Hospitalier Universitaire, UMR-S1077, Caen, France

    Shailendra Segobin, Renaud La Joie, Ludivine Ritz, Hélène Beaunieux, Béatrice Desgranges, Gaël Chételat, Anne Lise Pitel & Francis Eustache

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Segobin, S., La Joie, R., Ritz, L. et al. FDG-PET Contributions to the Pathophysiology of Memory Impairment. Neuropsychol Rev 25, 326–355 (2015). https://doi.org/10.1007/s11065-015-9297-6

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