This report presents our studies of the ATP-dependent and calcium mechanisms of the effects of salicylates on the electrical activity of neurons in the mollusk Helix albescens Rossm. Adenosine triphosphate (5·10–4 M) added simultaneously with salicylates in the extracellular medium significantly modified their neurotropic effects, eliminating the nonselective suppression of neuron spike activity by acetylsalicylic acid and increasing the activatory influences of cobalt and zinc acetylsalicylates. Blockade of uptake of Ca2+ into the neuroplasm from the extracellular medium and intracellular depots with 5·10–5 M and 5·10–4 M CdCl2 and BaCl2 had no significant effect on neuron responses to salicylates, suggesting that calcium mechanisms are not involved.
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Translated from Rossiiskii Fiziologicheskii Zhurnal imeni I. M. Sechenova, Vol. 101, No. 3, pp. 326–336, March, 2015.
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Cheretaev, I.V., Korenyuk, I.I., Khusainov, D.R. et al. ATP-Dependent and Calcium Mechanisms of the Effects of Salicylates on Electrical Potentials in Neurons in the Mollusk Helix Albescens . Neurosci Behav Physi 46, 644–651 (2016). https://doi.org/10.1007/s11055-016-0291-0
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DOI: https://doi.org/10.1007/s11055-016-0291-0