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Synthesizing Multi-Contrast MR Images Via Novel 3D Conditional Variational Auto-Encoding GAN

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Abstract

As two different modalities of medical images, Magnetic Resonance (MR) and Computer Tomography (CT), provide mutually-complementary information to doctors in clinical applications. However, to obtain both images sometimes is cost-consuming and unavailable, particularly for special populations. For example, patients with metal implants are not suitable for MR scanning. Also, it is probably infeasible to acquire multi-contrast MR images during once clinical scanning. In this context, to synthesize needed MR images for patients whose CT images are available becomes valuable. To this end, we present a novel generative network, called CAE-ACGAN, which incorporates the advantages of Variational Auto-Encoder (VAE) and Generative Adversarial Network (GAN) with an auxiliary discriminative classifier network. We apply this network to synthesize multi-contrast MR images from single CT and conduct experiments on brain datasets. Our main contributions can be summarized as follows: 1)We alleviate the problems of images blurriness and mode collapse by integrating the advantages of VAE and GAN; 2) We solve the complicated cross-domain, multi-contrast MR synthesis task using the proposed network; 3) The technique of random-extraction-patches is used to lower the limit of insufficient training data, enabling to obtain promising results even with limited available data; 4) By comparing with other typical networks, we are able to yield nearer-real, higher-quality synthetic MR images, demonstrating the effectiveness and stability of our proposed network.

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Data availability

The dataset used to support the findings of this study are available from the corresponding author upon request.

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Funding

This work was partly supported by the National Natural Science Foundation of China under grants 61772241 and 61702225, by the Natural Science Foundation of the Jiangsu Higher Education Institutions of China under grant 18KJB520048, by the Science and Technology Demonstration Project of Social Development of Wuxi under grant WX18IVJN002, and by JiangSu 333 Expert Engineering under grant BRA2019189.

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Authors and Affiliations

  1. School of Artificial Intelligence and Computer Science, Jiangnan University, Wuxi, 214122, China

    Huan Yang, Yizhang Jiang & Pengjiang Qian

  2. Jiangsu Key Laboratory of Media Design and Software Technology, Jiangnan University, Wuxi, 214122, China

    Huan Yang, **anling Lu, Yizhang Jiang & Pengjiang Qian

  3. School of Internet of Things Engineering, Jiangnan University, Wuxi, 214122, China

    Huan Yang & **anling Lu

  4. School of Architecture Building and Civil Engineering, Loughborough University, Loughborough, LE11 3TU, UK

    Shui-Hua Wang

  5. School of Educational Science, Nan**g Normal University, Nan**g, 210096, China

    Zhihai Lu

  6. Wuxi IoT Innovation Center Co., Ltd, Wuxi, 214000, China

    Jian Yao

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  1. Huan Yang
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  3. Shui-Hua Wang
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Correspondence to **anling Lu or Pengjiang Qian.

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The code used to implement the findings of this study are available from the corresponding author upon request.

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Yang, H., Lu, X., Wang, SH. et al. Synthesizing Multi-Contrast MR Images Via Novel 3D Conditional Variational Auto-Encoding GAN. Mobile Netw Appl 26, 415–424 (2021). https://doi.org/10.1007/s11036-020-01678-1

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