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Preparation and application of poly(α-L-lysine)-based interpenetrating network hydrogel via synchronous free-radical polymerization and amine-anhydride reaction in water

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Abstract

Drug- controlled delivery can effectively avoid excessive drug use and improve the utilization rate of drugs and reduce the harm of drugs to the body. Herein, a novel poly(α-L-lysine)-based interpenetrating network (IPN) hydrogel with thermo/pH sensitivity was fabricated by synchronous free-radical polymerization and amine-anhydride click reaction in one pot. The hydrogels were characterized by FTIR, X-ray diffraction (XRD), and scanning electron microscopy (SEM). The IPN hydrogels well integrated thermo-sensitivity and pH-sensitivity of two single-network hydrogels. The experimental results showed that the IPN hydrogel exhibited different swelling properties at different pH and temperatures. Finally, the anticancer drug 5-fluorouracil (5-Fu) was chosen as a model drug to investigate the controlled release behavior of the hydrogel. The study showed that the release behavior of 5-Fu from the IPN hydrogel depended on temperature and pH changes, which followed the Korsmeyer-Peppas kinetic model. The IPN hydrogel is expected to be a candidate material for drug sustained-release carriers.

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Acknowledgements

The work was supported by Natural Science Project of Zhengzhou Science and Technology Bureau [grant number 21ZZXTCX14]; the Innovative Funds Plan of Henan University of Technology [grant number: 2021ZKCJ08]; Henan University of Technology [grant number: HAUTZX202003]; the National Natural Science Foundation of China [grant number: U1904171]; the Key Science and Technology Project of Henan Province, China [grant number: 212102210630].

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  1. School of Chemistry and Chemical Engineering, Henan University of Technology, 450001, Zhengzhou, PR China

    Chunwang Hu, Hongliang Wei, Bingyan Hua, Yaqi Zhang, Gang Wang, Yanmin Shen & Yongsheng Niu

  2. College of Chemistry and Environmental Engineering, Anyang Institute of Technology, Anyang, PR China

    Yongsheng Niu

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  1. Chunwang Hu
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  2. Hongliang Wei
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Hu, C., Wei, H., Hua, B. et al. Preparation and application of poly(α-L-lysine)-based interpenetrating network hydrogel via synchronous free-radical polymerization and amine-anhydride reaction in water. J Polym Res 29, 194 (2022). https://doi.org/10.1007/s10965-022-03054-x

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