Log in

Innovation capacity in the healthcare sector and historical anchors: examples from the UK, Switzerland and the US

  • Published:
The Journal of Technology Transfer Aims and scope Submit manuscript

Abstract

Innovation is an integral part of economic development in developed economies. In the post 2008 period, a key policy agenda is that of sustainable development, which calls for innovation in all aspects of value-chains. In this paper, we focus on innovation from the biotech—pharma perspective to see whether or not this will lead to a sustainable future for the regions where there are clusters of firms in this sector. We examine data from a recently completed European Union study of innovation in the Healthcare sector from the UK and Switzerland, countries with an historical base in pharma, to understand how innovation pathways vary at the regional level in the broader life sciences, which incorporate biotech and more. Innovation in the healthcare sector in two regions, Oxfordshire in the UK and Zurich in Switzerland are compared. We contextualize our discussion by drawing on studies that focus on the sector in the US, specifically Boston. The analytical framework comprises three elements: innovation systems and national and regional economic development theories are the first two, followed by approaches which consider organizational or institutional activity. This framework is used to help explain and understand the complexity of how innovation is organized at the sub-national level. The overall context is that it is increasing becoming a condition for government financing of research that it has more immediate application in industry or have the possibility of commercialisation (e.g., translational research).

This is a preview of subscription content, log in via an institution to check access.

Access this article

Subscribe and save

Springer+ Basic
EUR 32.99 /Month
  • Get 10 units per month
  • Download Article/Chapter or Ebook
  • 1 Unit = 1 Article or 1 Chapter
  • Cancel anytime
Subscribe now

Buy Now

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

Notes

  1. http://vrr.healthties.eu/. Accessed 26 January 2015.

  2. http://www.massbio.org/. Accessed 22 February 2015.

  3. http://www.swissbiotech.org/Php5/aa2/UserFiles/File/pdf/swissbiotechreport/SBR_2014.pdf. Accessed 26 November 2014.

  4. http://www.scoopproject.org.uk/1frida-anchor-firms-contribute-to-regional-development.aspx. Accessed 29 December 2014.

  5. Data are available at http://vrr.healthties.eu/. Accessed 3 June 2013.

  6. http://www.bioindustry.org/home/. Accessed 26 November 2014.

  7. https://www.gov.uk/government/organisations/office-for-life-sciences. Accessed 7 June 2014.

  8. https://www.gov.uk/government/uploads/system/uploads/attachment_data/file/427769/BIS-15-224-BIS-strength-opp-2014.pdf. Accessed 14 July 2015.

  9. http://www.telegraph.co.uk/finance/newsbysector/industry/9966414/Cambridge-home-of-Britains-biotech-boom-offers-relief-to-UK-economic-ills.html. Accessed 26 January 2015.

  10. http://www.obn.org.uk/. Accessed 21 January 2015.

  11. http://www.en.scienceindustries.ch/_file/9257/branchenportrait-e.pdf. Accessed 26 January 2015.

  12. http://www.interpharma.ch/sites/default/files/polynomics-2011_bedeutung-der-pharmaindustrie-fuer-die-schweiz_e.pdf. Accessed 26 January 2015.

  13. http://www.roche.ch/en/standorte/schlieren.htm. Accessed 26 January 2015.

  14. http://www.timeshighereducation.co.uk/world-university-rankings/2014-15/subject-ranking/subject/life-sciences. Accessed 22 February 2015.

  15. http://www.ref.ac.uk/. Accessed 28 July 2015.

  16. http://www.abpi.org.uk/industry-info/knowledge-hub/global-industry/Pages/industry-market-.aspx. Accessed 26 February 2015.

  17. http://www.massbio.org/economic_development/the_massachusetts_supercluster. Accessed 21 January 2015.

References

  • Agrawal, R., Audretsch, D., & Sarkar, M. B. (2007). The process of creative construction: Knowledge spillovers, entrepreneurship and economic growth. Strategic Entrepreneurship Journal, 1, 263–286.

    Article  Google Scholar 

  • Agrawal, A., & Cockburn, I. (2003). The anchor tenant hypothesis: Exploring the role of large, local, R&D intensive firms in regional innovation systems. International Journal of Industrial Organization, 21, 1227–1253.

    Article  Google Scholar 

  • Ankrah, S. N., Burgess, T. F., Grimshaw, P., & Shaw, N. E. (2013). Asking both university and industry actors about their engagement in knowledge transfer: What single-group studies of motives omit. Technovation, 33, 50–65.

    Article  Google Scholar 

  • Asheim, B., & Coenen, L. (2005). Knowledge bases and regional innovation systems: Comparing Nordic clusters. Research Policy, 34, 1173–1190.

    Article  Google Scholar 

  • Asheim, B., Cooke, P., & Martin, R. (2006). Clusters and regional development: Critical reflections and explorations. London: Routledge.

    Google Scholar 

  • Atkinson, R. (2014). Understanding the U.S. National Innovation System. http://www2.itif.org/2014-understanding-us-innovation-system.pdf. Accessed 21 January 2015.

  • Autant-Bernard, C., Mangematin, V., & Massard, N. (2006). Creation of Biotech SMEs in France. Small Business Economics, 26(2), 173–187.

    Article  Google Scholar 

  • Boschma, R., & Frenken, K. (2011). The emerging empirics of evolutionary economic geography. Journal of Economic Geography, 11(2), 295–308.

    Article  Google Scholar 

  • Breznitz, S., & Anderson, W. P. (2006). Boston metropolitan area biotechnology cluster. Canadian Journal of Regional Science, 28(2), 249–264.

    Google Scholar 

  • Carlsson, B., Jacobsson, S., Holmén, M., & Rickne, A. (1999). Innovation systems: Analytical and methodological issues. http://www.druid.dk/conferences/summer1999/conf-papers/carlsson.pdf. Accessed 10 November 2014.

  • Casper, S. (2013). The spill-over theory reversed: The impact of regional economies on the commercialization of university science. Research Policy, 42, 1313–1324.

    Article  Google Scholar 

  • Clarysse, B., Wright, M., & Van de Velde, E. (2011). Entrepreneurial origin, technological knowledge, and the growth of spin-off companies. Journal of Management Studies, 48, 1420–1442.

    Article  Google Scholar 

  • Cooke, P. (1992). Regional innovation systems: Competitive regulation in the new Europe. Geoforum, 23(3), 365–382.

    Article  Google Scholar 

  • Cooke, P. (1998). Introduction: Origins of the concept. In H.-J. Braczyk, P. Cooke, & M. Heidenreich (Eds.), Regional innovation systems: The role of governances in a globalized world (pp. 2–25). London: UCL Press.

    Google Scholar 

  • Cooke, P. (2001). Clusters as key determinants of economic growth: The example of biotechnology. http://www.nordregio.se/Global/Publications/Publications%202001/R2001_2/R0102_p23.pdf. Accessed 22 February 2015.

  • Dicken, P. (2015). Global shift: Map** the changing contours of the world economy (7th ed.). London: Sage.

    Google Scholar 

  • Etzkowitz, H. (1983). Entrepreneurial scientists and entrepreneurial universities in American academic science. Minerva, 21, 198–233.

    Article  Google Scholar 

  • Etzkowitz, H., & Leydesdorff, L. (1995). The triple helix—university–industry–government relations: A laboratory for knowledge-based economic development. EASST Review, 14, 14–19.

    Google Scholar 

  • Fagerberg, J., Feldman, M., & Srholec, M. (2014). Technological dynamics and social capability: US and Europe. Journal of Economic Geography, 14, 313–333.

    Article  Google Scholar 

  • Feldman, M. P. (2000). Location and innovation: The new economic geography of innovation, spillovers, and agglomeration. In G. Clark, M. Feldman, & M. Gertler (Eds.), Oxford handbook of economic geography. Oxford: Oxford University Press.

    Google Scholar 

  • Feldman, M. P. (2003). The location dynamics of the US biotech industry: Knowledge externalities and the anchor hypothesis. Industry and Innovation, 10(3), 311–328.

    Article  Google Scholar 

  • Feldman, M. P. (2014). The character of innovative places: Entrepreneurial strategy, economic development and prosperity. Small Business Economics, 43(1), 9–20.

    Article  Google Scholar 

  • Freeman, C. (1995). The national system of innovation in historical perspective. Cambridge Journal of Economics, 19(1), 5–24.

    Google Scholar 

  • Gertler, M., & Levitte, Y. (2005). Local nodes in global networks: The geography of knowledge flows in biotechnology innovation. Industry and Innovation, 12(4), 487–507.

    Article  Google Scholar 

  • Goto, A. (2000). Japan’s national innovation system: Current status and problems. Oxford Review of Economic Policy, 16(2), 103–113.

    Article  Google Scholar 

  • Hirsch, J. E. (2005). An index to quantify an individual’s scientific research output. Proceedings of the National Academy of Sciences of the United States of America, 102, 16569–16572.

    Article  Google Scholar 

  • Jong, S. (2008). Academic organizations and new industrial fields: Berkeley and Stanford after the rise of biotechnology. Research Policy, 37(8), 1267–1282.

    Article  Google Scholar 

  • Jong, S., & Slavova, K. (2014). When publications lead to products: The open science conundrum in new product development. Research Policy, 43, 645–654.

    Article  Google Scholar 

  • Konishi, H., & Sandfort, M. T. (2003). Anchor stores. Journal of Urban Economics, 53(3), 413–435.

    Article  Google Scholar 

  • Lawton Smith, H. (2005). The biotechnology industry in Oxfordshire: Enterprise and innovation. European Planning Studies, 12(7), 985–1002.

    Google Scholar 

  • Lawton Smith, H., & Bagchi-Sen, S. (2010). Triple helix and regional development: A perspective from Oxfordshire in the UK. Technology Analysis and Strategic Management, 22, 805–818.

    Article  Google Scholar 

  • Lawton Smith, H., & Bagchi-Sen, S. (2012). The research university, entrepreneurship and regional development: Research propositions and current evidence. Entrepreneurship and Regional Development: An International Journal, 24, 383–404.

    Article  Google Scholar 

  • Lawton Smith, H., Romeo, S., & Bagchi-Sen, S. (2008). Oxfordshire biomedical university spin-offs: An evolving system. Cambridge Journal of Regions, Economy and Society, 1(2), 303–319.

    Article  Google Scholar 

  • Lundvall, B.-Å. (1988). Innovation as an interactive process—From user-producer interaction to national systems of innovation. In G. Dosi, C. Freeman, R. Nelson, G. Silverberg, & L. L. G. Soete (Eds.), Technical change and economic theory (pp. 349–367). London: Pinter.

    Google Scholar 

  • Lundvall, B. (1992). User–producer relationships, national systems of innovation and internationalisation. In B. Lundvall (Ed.), National systems of innovation: Towards a theory of innovation and interactive learning. London: Pinter.

    Google Scholar 

  • Malerba, F. (2002). Sectoral systems of innovation and production. Research Policy, 1, 247–264.

    Article  Google Scholar 

  • Malerba, F. (2005). Sectoral systems: How and why innovation differs across sectors. In J. Fagerberg, D. C. Mowery, & R. R. Nelson (Eds.), The Oxford handbook of innovation (pp. 380–406). New York, NY: Oxford University Press.

    Google Scholar 

  • Markusen, A. (1996). Sticky places in slippery space: A typology of industrial districts. Economic Geography, 7(3), 293–313.

    Article  Google Scholar 

  • McKelvey, M. (2004). Evolutionary perspectives on the regional–national–international dimensions of biotechnology innovation. Environment and Planning C, 22(2), 179–198.

    Article  Google Scholar 

  • McKelvey, A. H., & Riccaboni, M. (2003). Does co-location matter for formal knowledge collaboration in the Swedish pharmaceutical sector? Research Policy, 32, 483–501.

    Article  Google Scholar 

  • Minshall, T. H. W., & Wicksteed, W. (2005). University spin-out companies: Starting to fill the evidence gap. A report for the Gatsby Charitable Foundation. http://www.stjohns.co.uk/documents/usoreport.pdf.

  • Nelson, R. (1988). Institutions supporting technical change in the United States Ch 15. In G. Dosi, C. Freeman, R. Nelson, G. Silverberg, & L. Soete (Eds.), Technical change and economic theory (pp. 312–330). London: Pinter.

    Google Scholar 

  • Nelson, R. (1993). National innovation systems: A comparative analysis. Oxford, NY: University Press.

    Google Scholar 

  • Niosi, J., & Zhegu, M. (2010). Anchor tenants and regional innovation systems: The aircraft industry. International Journal of Technology Management, 50(3/4), 263–284.

    Article  Google Scholar 

  • Perkmann, M., Tartari, V., McKelvey, M., Autio, E., Brostrom, A., D’Este, P., et al. (2013). Academic engagement and commercialisation: A review of the literature on university–industry relations. Research Policy, 42, 423–442.

    Article  Google Scholar 

  • Perry, B., & May, T. (2007). Governance, science policy and regions: An introduction. Regional Studies, 41(8), 1039–1050.

    Article  Google Scholar 

  • Porter, M. E. (1998). Clusters and the new economics of competition. Harvard Business Review, 76(6), 77–90.

    Google Scholar 

  • Romeo, S., & Lawton Smith, H. (2014). The biotechnology system in Oxfordshire: A long history. In L. Farinha, J. Ferreira, H. Lawton Smith, & S. Bagchi-Sen (Eds.), Handbook of research on global competitive advantage through innovation and entrepreneurship. USA: IGI Global.

    Google Scholar 

  • Shane, S. (2004). Academic entrepreneurship: University spinoffs and wealth creation. Cheltenham: Edward Elgar.

    Book  Google Scholar 

  • Spencer, G. M. (2013). The economic impact of anchor firms and industrial clusters: An analysis of Canadian and American manufacturing firms and clusters. Industry Canada. https://localideas.files.wordpress.com/2014/05/anchor-firms-and-clusters.pdf. Accessed 28 July 2015.

  • Tracey, P., Clark, G., & Lawton, Smith. H. (2004). Cognition, learning and European regional growth: A agent-centred perspective on the “new” economy. Economics of Innovation and New Technology, 13(1), 1–18.

    Article  Google Scholar 

  • Weil, T., Glaser, A., Gallié, E-P., Mérindol, V., Lefebvre, P., & Pallez, F. (2010). Why are good comparative studies of networks so rare? Practical lessons from a study on French clusters. https://hal.archives-ouvertes.fr/hal-00488404/document. Accessed 21 January 2015.

  • Wintjes, R., & Hollanders, H. (2011). Innovation pathways and policy challenges at the regional level: Smart specialization. UNU-MERIT working paper series no. 2011-027.

Download references

Acknowledgments

We thank John Slater for his comments on an earlier version of this paper. Laurel Edmunds is supported by the NIHR Oxford BRC.

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Helen Lawton Smith.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Lawton Smith, H., Bagchi-Sen, S. & Edmunds, L. Innovation capacity in the healthcare sector and historical anchors: examples from the UK, Switzerland and the US. J Technol Transf 41, 1420–1439 (2016). https://doi.org/10.1007/s10961-015-9442-7

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10961-015-9442-7

Keywords

JEL Classification

Navigation