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Inhibition Conversion of Aspirin into Salicylic Acid in Presence of Glycine

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Abstract

Aspirin (AS) is a common drug having anti-pyretic and anti-inflammatory properties which is widely used in diverse medical conditions. The intake of AS may cause adverse effects such as gastrointestinal ulcer, tinnitus and Reye’s syndrome. The adverse effects of AS arise due to conversion of AS into salicylic acid (SAL). Glycine (Gly) is a simplest non essential amino acid having anti-oxidative and anti-inflammatory effects. It also reduces the risk of obesity, hypertension, and diabetes mellitus. AS with Gly is well accepted form of the drug for the treatment of rheumatic conditions in comparisons to the bare AS. In the present work using UV-Visible absorption, fluorescence and DFT/ TD-DFT techniques confirmed that in presence of Gly inhibited the conversion of AS into SAL effectively.

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Data Availability

No datasets were generated or analysed during the current study.

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Acknowledgements

Ranjana Singh want to express her sincere thanks to CSIR New Delhi, Govt. of India for providing financial support in terms of CSIR Research Associate ship with file no 09/13 (0846)/2018-EMR-I dated 29/03/2019. Authors are extremely thankful to Dr. Anurag Mishra and Biophysics Laboratory, Department of Physics, B.H.U. Varanasi, India to provide the instrumental facility Edinburg FLS 900 fluorescence spectrophotometer for PL measurement and UV-Visible absorption spectrometer.

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Authors and Affiliations

  1. Department of Physics, Institute of Science, Banaras Hindu University, Varanasi, 221005, India

    Ranjana Singh & Ranjan K. Singh

  2. Government Polytechnic Rajgrah, Mirzapur, 231001, India

    Ranjana Singh

  3. Department of Physics, Mahatama Gandhi Kashi Vidya Peeth, Varanasi, 221002, India

    Manish K. Tiwari

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  1. Ranjana Singh
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Contributions

Ranjana Singh contributed to the experiment design and execution of the experiments for data collection. She has also actively participated in data analysis and correlation of the experimental findings with the theoretical calculations. Manish K. Tiwari contributed into DFT and TD-DFT calculations. All authors contributed to the results discussions. The manuscript has been prepared in the supervision of Ranjan K. Singh. It was also corrected and revised by Ranjan K. Singh. All authors read and approved the final manuscript.

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Correspondence to Ranjana Singh or Ranjan K. Singh.

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Singh, R., Tiwari, M.K. & Singh, R.K. Inhibition Conversion of Aspirin into Salicylic Acid in Presence of Glycine. J Fluoresc (2024). https://doi.org/10.1007/s10895-024-03675-z

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