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A Highly Selective Fluorescent Probe for Hydrogen Sulfide and its Application in Living Cell

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Abstract

A new Near-infrared fluorescent probe for hydrogen sulfide detection was synthesized by employing dicyanoisophorone based fluorescence dye as a fluorophore and methyl 3-(2-(carbonyl)phenyl)-2-cyanoacrylate group as the response unit. The Probe DCI-H2S showed a long emission wavelength (λem = 674 nm). Based on the H2S-induced addition–cyclization of deprotecting methyl 3-(2-(carbonyl)phenyl)-2-cyanoacrylate group, the probe DCI-H2S showed high selectivity, sensitivity and response speed toward hydrogen sulfide under room temperature. These numerous advantages of the probe DCI-H2S make it to potentially detect endogenous hydrogen sulfide in living organisms.

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Data Availability

No datasets were generated or analysed during the current study.

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Funding

This work was supported by the National Natural Science Foundation of China (No. 21702178).

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Authors and Affiliations

  1. Key Laboratory of Micro-Nano Materials for Energy Storage and Conversion of Henan Province, Drug Intermediates Engineering Research Center for Cleaner Production of Henan Province, College of Chemical and Materials Engineering, Xuchang University, Henan, 461000, PR China

    Zhiyu Ju, Yuxiang Zhang & Lingyu Kong

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  1. Zhiyu Ju
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  2. Yuxiang Zhang
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  3. Lingyu Kong
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Contributions

All authors contributed to the study conception and design. Material preparation, data collection and analysis were performed by [Zhiyu Ju], [Yuxiang Zhang], and [Lingyu Kong]. The first draft of the manuscript was written by [Zhiyu Ju] and all authors commented on previous versions of the manuscript. All authors read and approved the final manuscript.

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Correspondence to Zhiyu Ju.

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Ju, Z., Zhang, Y. & Kong, L. A Highly Selective Fluorescent Probe for Hydrogen Sulfide and its Application in Living Cell. J Fluoresc (2024). https://doi.org/10.1007/s10895-024-03601-3

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