Abstract
In the last years considerable research and development activity have been expended to find new ceramic bone substitutes for the treatment of bone defects. However in many cases the drawback of synthethic bone substitutes are the slow graft incorporation and remodelling into the host bone. The purpose of this study was to analyze the kinetics of resorption and new bone formation of new calcium sulfate (CaSO4)/calcium phosphate (CaPO4) bioceramic engineered to enhance its bone forming properties. We prospectively evaluated the results of a series of 15 hips with osteonecrosis of the femoral head (ONFH) treated at with core decompression and injection of the CaSO4/CaPO4 composite. In all hips, a quantitative computed tomography (QTC) scan was taken within one week after the surgery, at 12 months, 2 years and finally with a minimum of 4 years follow-up. The mean HU in the immediate post-operative period was 1445 (Range 1388–1602); At one year the mean HU strongly decrease at 556.6 HU (P < 0.01); The mean HU at 2 years follow-up further decreased to 475.1. The mean HU at 4 years was unchanged. The quantitative and qualitative CT scan data of this series indicates that the CaSO4-CaPO4 ceramic composite resorbs over a narrow timeframe and the gradual resorption of the graft within the defect provides an ideal environment for the direct new bone growth that propagates across the defect.
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Bohner M, Galea L, Doebelin N. Calcium phosphate bone graft substitutes: Failures and hopes. J Eur Ceram Soc. 2012;32:2663–71.
Whitehouse MR, Ashley WB. The use of ceramics as bone substitutes in revision hip arthroplasty. Materials. 2009;2:1895–907.
Urban RM, Turner TM, Hall DJ, Inoue N, Gitelis S. Increased bone formation using a calcium sulfate and calcium phosphate composite graft. Clin Orthop Relat Res. 2007;459:110–7.
Hungerford DS. The use of an injectable calcium sulphate/calcium phosphate composite in the treatment of the osteonecrosis of the femoral head. J Bone J Surg Br. 2009;91:331.
Civinini R, De Biase P, Carulli C, Matassi F, Nistri L, Capanna R, Innocenti M. The use of an injectable calcium sulphate/calcium phosphate bioceramic in the treatment of osteonecrosis of the femoral head. Int Orthop. 2012;36(8):1583–8.
Steinberg ME, Steinberg DR. Classification systems for osteonecrosis: an overview. Orthop Clin North Am. 2004;35:273–83.
Houndsfield GN. Nobel Award address. Computed medical imaging. Med Phys. 1980;7(4):283–90.
Harris WH. Traumatic arthiritis of the hip after dislocation and acetabular fractures: treatment by mold arthroplasty. An end-result study using a new method of result evaluation. J Bone Joint Surg Am. 1969;51:737–755.
Larsson S, Hannink G. Injectable bone graft substitutes: current products, their characteristics and indications and new developments. Injury. 2011;42:S30–4.
Bucholz RW. Nonallograft osteoconductive bone graft substitutes. Clin Orthop Relat Res. 2002;395:44–52.
Ambard AJ, Mueninghoff L. Calcium phosphate cement: review of mechanical and biological properties. J Prosthodont. 2006;15(5):321–8.
Zhang J, Liu W, Schnitzler V, Tancret F, Bouler JM. Calcium phosphate cements for bone substitution: chemistry, handling and mechanical properties. Acta Biomaterialia. 2014;10:1035–49.
Ginebra MP, Traykova T, Planell JA. Calcium phosphate cements as bone drug delivery systems: a review. J Control Release. 2006;113:102–10.
Ginebra MP, Espanol M, Montufar EB, Perez RA, Mestres G. New processing approaches in calcium phosphate cements and their applications in regenerative medicine. Acta Biomater. 2010;6:2863–73.
Ginebra MP, Canal C, Espanol M, Pastorino D, Montufar EB. Calcium phosphate cements as drug delivery materials. Adv Drug Deliv Rev. 2012;64:1090–110.
LeGeros RZ. Properties of osteoconductive biomaterials: calcium phosphates. Clin Orthop Relat Res. 2002;395:81–98.
Bernstein A, Niemeyer P, Salzmann G, Südkamp NP, Hube R, Klehm J, Menzel M, von Eisenhart-Rothe R, Bohner M, Görz L, Mayr HO. Microporous calcium phosphate ceramics as tissue engineering scaffolds for the repair of osteochondral defects: histological results. Acta Biomater. 2013;9(7):7490–505.
Kelly CM, Wilkins RM, Gitelis S, Hartjen C, Watson JT, Kim PT. The use of a surgical grade calcium sulfate as a bone graft substitute: results of a multicenter trial. Clin Orthop Relat Res. 2001;382:42–50.
Urban RM, Turner TM, Hall DJ, Infanger S, Cheema N, Lim TH. Healing of large defects treated with calcium sulfate pellets containing demineralized bone matrix particles. Orthopedics. 2003;26(5 Suppl):s581–5.
Guo H, Wei J, Liu CS. Development of a degradable cement of calcium phosphate and calcium sulfate composite for bone reconstruction. Biomed Mater. 2006;1(4):193–7.
Zhu X, Chen X, Chen C, Wang G, Gu Y, Geng D, Mao H, Zhang Z, Yang H. Evaluation of calcium phosphate and calcium sulfate as injectable bone cements in sheep vertebrae. J Spinal Disord Tech. 2012;25(6):333–7.
Turner TM, Urban RM, Gitelis S, Kuo KN, Andersson GB. Radiographic and histologic assessment of calcium sulfate in experimental animal models and clinical use as a resorbable bone-graft substitute, a bone-graft expander, and a method for local antibiotic delivery: one institution’s experience. J Bone Joint Surg Am. 83-A Suppl. 2001;2(Pt 1):8–18.
Hu G, **ao L, Fu H, Bi D, Ma H, Tong P. Study on injectable and degradable cement of calcium sulphate and calcium phosphate for bone repair. J Mater Sci Mater Med. 2010;21(2):627–34.
Fillingham YA, Lenart BA, Gitelis S. Function after injection of benign bone lesions with a bioceramic. Clin Orthop Relat Res. 2012;470(7):2014–20.
Evaniew N, Tan V, Parasu N, Jurriaans E, Finlay K, Deheshi B, Ghert M. Use of a calcium sulfate-calcium phosphate synthetic bone graft composite in the surgical management of primary bone tumors. Orthopedics. 2013;36(2):e216–22. doi:10.3928/01477447-20130122-25.
Landgraeber S, Theysohn JM, Classen T, Jäger M, Warwas S, Hohn HP, Kowalczyk W. Advanced core decompression, a new treatment option of avascular necrosis of the femoral head--a first follow-up. J Tissue Eng Regen Med. 2013;7(11):893–900.
Lazik A, Landgraeber S, Claßen T, Kraff O, Lauenstein TC, Theysohn JM. Aspects of postoperative magnetic resonance imaging of patients with avascular necrosis of the femoral head, treated by advanced core decompression. Skeletal Radiol. 2015;44(10):1467–75. doi:10.1007/s00256-015-2192-7.
Classen T, Warwas S, Jäger M, Landgraeber S. Two-year follow-up after advanced core decompression. J Tissue Eng Regen Med. 14 (2015). doi:10.1002/term.2056.
Kotnis NA, Parasu N, Finlay K, Jurriaans E, Ghert M. Chronology of the radiographic appearances of the calcium sulphate-calcium phosphate synthetic bone graft composite following resection of bone tumours–a preliminary study of the normal post-operative appearances. Skeletal Radiol. 2011;40(5):563–70. doi:10.1007/s00256-010-1037-7.
Tan V, Evaniew N, Finlay K, Jurriaans E, Ghert M, Deheshi B, Parasu N. Chronology of the radiographic appearances of the calcium sulfate-calcium phosphate synthetic bone graft composite following resection of bone tumors: a follow-up study of postoperative appearances. Can Assoc Radiol J. 2015;15:21–7.
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Civinini, R., Capone, A., Carulli, C. et al. The kinetics of remodeling of a calcium sulfate/calcium phosphate bioceramic. J Mater Sci: Mater Med 28, 137 (2017). https://doi.org/10.1007/s10856-017-5940-5
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DOI: https://doi.org/10.1007/s10856-017-5940-5