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γ-Ray measurements in boron neutron capture therapy using BeO ceramic thermoluminescence dosimeter

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Abstract

In boron neutron capture therapy (BNCT), neutrons and γ-rays cause different biological effects, and it is necessary to discriminate between them for treatment planning and periodic inspections. Currently, the BeO powder thermoluminescence dosimeter (BeO powder TLD) is used for γ-ray dosimetry in mixed neutron and γ-ray fields due to the small capture cross section for neutrons, but correction is required because of the effects of neutron-induced activation. Besides, sales of BeO powder TLDs have been discontinued because the highly toxic BeO is readily dispersed when the detector is damaged. Therefore, the development of alternative replacement technologies for BeO powder TLDs that are not affected by neutrons is an important issue. In this study, we investigated the measurement of the γ-ray dose during BNCT using a BeO ceramic TLD, whereby the BeO was not released into the air. After 5, 15, 30, and 60 min of irradiation using the Kyoto University Research Reactor, the amount of thermoluminescence (TL) from the BeO ceramic TLD was shown to increase with irradiation time. In addition, the γ-ray dose, which was derived by converting the amount of TL to the dose, showed excellent proportionality to the irradiation time and was found to be comparable to the γ-ray dose measured with a BeO powder TLD. These results demonstrated that the BeO ceramic TLD can selectively measure only the γ-ray dose without influence by neutrons. Thus, our approach represents a new γ-ray dose measurement strategy that does not require correction for the contribution from thermal neutrons.

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Data availability

All data used in this study are available from the corresponding author on reasonable request.

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Acknowledgements

This work was performed as part of a Visiting Researcher Program at the Kyoto University Research Reactor.

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The authors have not disclosed any funding.

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Authors and Affiliations

  1. Tokyo Metropolitan University, 7-2-10 Higashi-Ogu, Arakawa-ku, Tokyo, 116-8551, Japan

    Masaya Tanaka, Ryoken Oh, Natsumi Sugioka, Satoru Sugawara, Toru Negishi & Kiyomitsu Shinsho

  2. Kyoto University, 2 Asashironishi, Kumatori-cho, Sennan-gun, Osaka, 590-0494, Japan

    Hiroki Tanaka & Takushi Takata

  3. Kindai University, 3-4-1 Kowakae, Higashiosaka-city, Osaka, 577-8502, Japan

    Genichiro Wakabayashi

  4. Kyushu University, 744 Motoka, Fukuoka Nishi-ku, Fukuoka, 819-0395, Japan

    Kenichi Watanabe

  5. Nagoya University, Furo-cho, Nagoya Chikusa-ku, Aichi, 464-8603, Japan

    Akira Uritani, Sachiko Yoshihashi & Kosei Nagasaka

  6. Kanazawa Institute of Technology, 3-1 Yatsukaho, Hakusan-city, Ishikawa, 924-0838, Japan

    Go Okada

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  1. Masaya Tanaka
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Contributions

MT, NS, HT, TT, GW, KW, SY, KN, GO, TN, and KS were involved in study design and data interpretation. MT, RO, NS, HT, TT, GW, SS, KW, AU, SY, KN, GO, TN, and KS were involved in the data acquisition and analysis. All authors revised the manuscript, approved the manuscript to be published, and agreed to be accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved.

Corresponding author

Correspondence to Kiyomitsu Shinsho.

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The authors declare that there are no potential conflicts of interest or studies involving human participants and/or animals or informed consent that would affect the research reported in this paper.

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Tanaka, M., Oh, R., Sugioka, N. et al. γ-Ray measurements in boron neutron capture therapy using BeO ceramic thermoluminescence dosimeter. J Mater Sci: Mater Electron 33, 20271–20279 (2022). https://doi.org/10.1007/s10854-022-08843-0

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  • DOI: https://doi.org/10.1007/s10854-022-08843-0

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