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Validation of the structure–function correlation report from the heidelberg edge perimeter and spectral-domain optical coherence tomography

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Abstract

Purpose

To compare the diagnostic assessment of glaucoma specialists with an automated structure–function correlation report combining visual field (VF) and spectral-domain optical coherence tomography (SD-OCT) imagining in subjects with glaucoma.

Methods

This prospective, cross-sectional study was conducted at Wills Eye Hospital, Philadelphia, PA, USA. Subjects with glaucoma received ophthalmic examination, VF testing, and SD-OCT imaging. An automated report was generated describing structure–function correlations between the two structural elements [retinal nerve fiber layer (RNFL) and Bruch’s membrane opening-minimum rim width (MRW)] and VF sectors. Three glaucoma specialists masked to the automated report and to each other identified clinically significant structure–function correlations between the VF and SD-OCT reports. Raw agreement and chance-corrected agreement (kappa statistics) between the automated report and the clinical assessments were compared.

Results

A total of 53 eyes from 45 subjects with glaucoma were included in this study. The overall agreement between the automated report and clinical assessment comparing MRW and VF was good at 74.8% with a kappa of 0.62 (95% CI 0.55–0.69). Agreements for the six different MRW sections were moderate to good with kappa values ranging from 0.54 to 0.69. For mean RNFL thickness and VF comparisons, agreement between the automated report and clinical assessment was 75.4% with a kappa of 0.62 (95% CI 0.54–0.70). For different RNFL sectors, kappa values ranged from 0.47 (moderate agreement) to 0.80 (good agreement).

Conclusions

This study suggests that the automated structure–function report combining results from the SD-OCT and the HEP may assist in the evaluation and management of glaucoma.

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Acknowledgements

This study was made possible in part by the Wills Eye Innovation Grant No. WEF15064. Heidelberg Engineering provided the Optical Coherence Tomography and Visual Field testing platforms used in this study.

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Author notes

  1. Qi N. Cui

    Present address: Scheie Eye Institute, University of Philadelphia, Philadelphia, PA, USA

Authors and Affiliations

  1. Glaucoma Research Center, Wills Eye Hospital, Philadelphia, PA, 19107, USA

    Qi N. Cui, Scott J. Fudemberg, Arthur F. Resende, Thuy-Anh Vu, Chen Zhou, Kamran Rahmatnejad, Lisa A. Hark, Jonathan S. Myers, L. Jay Katz & Michael Waisbourd

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  1. Qi N. Cui
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  2. Scott J. Fudemberg
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  7. Lisa A. Hark
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  8. Jonathan S. Myers
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Corresponding author

Correspondence to Jonathan S. Myers.

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The authors declare that they have no conflict of interest.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

Informed consent

Informed consent was obtained from all individual participants included in the study.

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Cui, Q.N., Fudemberg, S.J., Resende, A.F. et al. Validation of the structure–function correlation report from the heidelberg edge perimeter and spectral-domain optical coherence tomography. Int Ophthalmol 39, 533–540 (2019). https://doi.org/10.1007/s10792-018-0836-z

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  • DOI: https://doi.org/10.1007/s10792-018-0836-z

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