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Corneal endothelial changes following a single session of selective laser trabeculoplasty for pseudoexfoliative glaucoma

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Abstract

Purpose

To evaluate corneal endothelial cell parameters after a single session of selective laser trabeculoplasty (SLT) in pseudoexfoliative glaucoma (PEG) patients.

Methods

Corneal endothelial cell parameters of 18 PEG patients were compared with 18 healthy subjects following SLT treatment. All patients underwent SLT treatment to 180 degrees of inferior trabecular meshwork. Corneal measurements were performed using specular microscopy (Noncon Robo SP8000, Konan Medical, Hyogo, Japan). Endothelial cell density (ECD), hexagonal cell ratio (HEX), coefficient of variation (CV) of the corneal endothelial cell layer and central corneal thickness of the patients were measured at each visit.

Results

There was a statistically significant decrease in ECD (p = 0.004) and a statistically significant increase in CV (p = 0.041) at superior cornea 1 week after SLT. They returned to pre-SLT values at 1 month. One hour post-SLT HEX of inferior cornea was statistically significantly reduced (p = 0.01). At central cornea, there was a significant increase in HEX after 1 week (p = 0.001). Post-SLT IOP showed a significant positive correlation with CV and significant negative correlation with HEX at superior and inferior cornea. There was no correlation between total laser energy used and endothelial cell parameters.

Conclusion

Effect of a single session of SLT on corneal endothelium of PEG patients appears to be transient, and superior cornea was more affected than central and inferior cornea. All parameters returned to pre-SLT values at 1 month after treatment.

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References

  1. Lowry EA, Greninger DA, Porco TC et al (2016) A comparison of resident-performed argon and selective laser trabeculoplasty in patients with open-angle glaucoma. J Glaucoma 25:e157–e161

    Article  PubMed  Google Scholar 

  2. Koucheki B, Hashemi H (2012) Selective laser trabeculoplasty in the treatment of open-angle glaucoma. J Glaucoma 21:65–70

    Article  PubMed  Google Scholar 

  3. Koktekır BE, Gedik S, Bakbak B (2013) Bilateral severe anterior uveitis after unilateral selective laser trabeculoplasty. Clin Exp Ophthalmol 41:305–307

    PubMed  Google Scholar 

  4. Kennedy JB, SooHoo JR, Kahook MY et al (2016) Selective laser trabeculoplasty: an update. Asia Pac J Ophthalmol (Phila) 5:63–69

    Article  Google Scholar 

  5. Rhee DJ, Krad O, Pasquale LR (2009) Hyphema following selective laser trabeculoplasty. Ophthalmic Surg Lasers Imaging 40:493–494

    Article  PubMed  Google Scholar 

  6. Ha JH, Bowling B, Chen SD (2014) Cystoid macular oedema following selective laser trabeculoplasty in a diabetic patient. Clin Exp Ophthalmol 42:200–201

    Article  PubMed  Google Scholar 

  7. Livanage SE, Kumaran N, De Alwis D (2014) Macular burns resulting from the accidental use of selective laser trabeculoplasty mode during a laser capsulotomy. Br J Ophthalmol 98:141–142

    Article  Google Scholar 

  8. Song J (2016) Complications of selective laser trabeculoplasty: a review. Clin Ophthalmol 10:137–143

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  9. Lee JW, Chan JC, Chang RT et al (2014) Corneal changes after a single session of selective laser trabeculoplasty for open-angle glaucoma. Eye 28:47–52

    Article  CAS  PubMed  Google Scholar 

  10. Regina M, Bunya VY, Orlin SE et al (2011) Corneal edema and haze after selective laser trabeculoplasty. J Glaucoma 20:327–329

    Article  PubMed  Google Scholar 

  11. Knickelbein JE, Singh A, Flowers BE et al (2014) Acute corneal edema with subsequent thinning and hyperopic shift following selective laser trabeculoplasty. J Cataract Refract Surg 40:1731–1735

    Article  PubMed  PubMed Central  Google Scholar 

  12. Song J, Song A, Palmares T, Song M (2014) Myopic shift following selective laser trabeculoplasty: a case report. Br J Med Med Res 4:1008–1013

    Article  Google Scholar 

  13. Atalay K, Kirgiz A, Seferoğlu Cabuk K et al (2016) Corneal topographic alterations after selective laser trabeculoplasty. Int Ophthalmol. 37:905–910 (Epub ahead of print)

    Article  PubMed  Google Scholar 

  14. Miraftabi A, Nilforushan N, Nassiri N et al (2016) Selective laser trabeculoplasty in patients with pseudoexfoliative glaucoma vs primary open angle glaucoma: a one-year comparative study. Int J Ophthalmol 9:406–410

    PubMed  PubMed Central  Google Scholar 

  15. Tebeanu E, Stefan C (2008) Specular microscopy and pseudoexfoliative syndrome. Oftalmologia 52:11–15

    PubMed  Google Scholar 

  16. Wang M, Sun W, Ying L, Dong XG (2012) Corneal endothelial cell density and morphology in Chinese patients with pseudoexfoliation syndrome. Int J Ophthalmol 5:186–189

    CAS  PubMed  PubMed Central  Google Scholar 

  17. Zheng X, Shiraishi A, Okuma S, Mizoue S, Goto T, Kawasaki S, Uno T, Miyoshi T, Ruggeri A, Ohashi Y (2011) In vivo confocal microscopic evidence of keratopathy in patients with pseudoexfoliation syndrome. Investg Ophthalmol Vis Sci 52:1755–1761

    Article  Google Scholar 

  18. Bozkurt B, Güzel H, Kamış Ü, Gedik Ş, Okudan S (2015) Characteristics of the anterior segment biometry and corneal endothelium in eyes with pseudoexfoliation syndrome and senile cataract. Turk J Ophthalmol 45:188–192

    Article  PubMed  PubMed Central  Google Scholar 

  19. Zheng X (2013) New findings for an old disease: morphological studies on pseudoexfoliation syndrome-related keratopathy and binocular asymmetry. Cornea 32:84–90

    Article  CAS  Google Scholar 

  20. Puska P, Vasara K, Harju M, Setälä K (2000) Corneal thickness and endothelium in normotensive subjects with unilateral exfoliation syndrome. Graefes Arch Clin Exp Ophthalmol 238:659–663

    Article  CAS  PubMed  Google Scholar 

  21. Wali UK, Bialasiewicz AA, Rizvi SG, Al-Belushi H (2009) In vivo morphometry of corneal endothelial cells in pseudoexfoliation keratopathy with glaucoma and cataract. Ophthalmic Res 41:175–179

    Article  PubMed  Google Scholar 

  22. De Juan-Marcos L, Cabrillo_Estèvez L, Escudero-Dominguez FA, Sánchez-Jara A, Hernández-Galilea E (2013) Morphometric changes of corneal endothelial cells in pseudoexfoliation syndrome and pseudoexfoliation glaucoma. Arch Soc Esp Oftalmol 88:439–444

    Article  PubMed  Google Scholar 

  23. Ayaki M, Noda Y, Yaguchi S, Koide R, Iwasawa A, Inoue T, Inoue Y (2009) Cytotoxicity of antiglaucoma ophthalmic solutions for human corneal endothelial cells. Nippon Ganka Gakkai Zasshi 113:576–582

    CAS  PubMed  Google Scholar 

  24. Fernández Jiménez-Ortiz H, Toledano Fernández N, Fernández Escamez CS, Perucho Martinez S, Crespo Carballés MJ (2013) The effects of ocular hypotensive drugs on the cornea: an in vivo analysis with confocal microscopy. Arch Soc Esp Oftalmol 88:423–432

    Article  PubMed  Google Scholar 

  25. Weber U (2012) Central corneal thickness and corneal endothelial morphology with and without therapy using commercially available antiglaucomatous drugs. Klin Monbl Augenheilkd 229:716–723

    CAS  PubMed  Google Scholar 

  26. Miraftabi A, Nilforushan N, Nassiri N, Nouri-Mahdavi K (2016) Selective laser trabeculoplasty in patients with pseudoexfoliative glaucoma vs primary open angle glaucoma: a one-year comparative study. Int J Ophthalmol 18(9):406–410

    Google Scholar 

  27. Ong K, Ong L, Ong LB (2015) Corneal endothelial abnormalities after selective laser trabeculoplasty (SLT). J Glaucoma 24:286–290

    Article  PubMed  Google Scholar 

  28. White AJ, Mukherjee A, Hanspal I, Sarkies NJ, Martin KR, Shah P (2013) Acute transient corneal endothelial changes following selective laser trabeculoplasty. Clin Exp Ophthalmol 41:435–441

    Article  PubMed  Google Scholar 

  29. Regina M, Bunya VY, Orlin SE, Ansari H (2011) Corneal edema and haze after selective laser trabeculoplasty. J Glaucoma 20:327–329

    Article  PubMed  Google Scholar 

  30. Moubayed SP, Hamid M, Choremis J, Li G (2009) An unusual finding of corneal edema complicating selective laser trabeculoplasty. Can J Ophthalmol 44:337–338

    Article  PubMed  Google Scholar 

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Authors and Affiliations

  1. Department of Ophthalmology, School of Medicine, Kırıkkale University, Kırıkkale, Turkey

    Nurgül Örnek

  2. Department of Ophthalmology, Kudret Eye Hospital, Kavaklıdere, Ankara, Turkey

    Kemal Örnek

  3. Göz Hastalıkları Anabilim Dalı, Kırıkkale Üniversitesi Tıp Fakültesi, 71450, Yahşihan, Kırıkkale, Turkey

    Nurgül Örnek

Authors
  1. Nurgül Örnek
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  2. Kemal Örnek
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Correspondence to Nurgül Örnek.

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The authors declare that they have no conflict of interest.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards.

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Informed consent was obtained from all individual participants included in the study.

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Örnek, N., Örnek, K. Corneal endothelial changes following a single session of selective laser trabeculoplasty for pseudoexfoliative glaucoma. Int Ophthalmol 38, 2327–2333 (2018). https://doi.org/10.1007/s10792-017-0730-0

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  • DOI: https://doi.org/10.1007/s10792-017-0730-0

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