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Deciphering Autoimmune Diseases: Unveiling the Diagnostic, Therapeutic, and Prognostic Potential of Immune Repertoire Sequencing

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Abstract

Autoimmune diseases (AIDs) are immune system disorders where the body exhibits an immune response to its own antigens, causing damage to its own tissues and organs. The pathogenesis of AIDs is incompletely understood. However, recent advances in immune repertoire sequencing (IR-seq) technology have opened-up a new avenue to study the IR. These studies have revealed the prevalence in IR alterations, potentially inducing AIDs by disrupting immune tolerance and thereby contributing to our comprehension of AIDs. IR-seq harbors significant potential for the clinical diagnosis, personalized treatment, and prognosis of AIDs. This article reviews the application and progress of IR-seq in diseases, such as multiple sclerosis, systemic lupus erythematosus, rheumatoid arthritis, and type 1 diabetes, to enhance our understanding of the pathogenesis of AIDs and offer valuable references for the diagnosis and treatment of AIDs.

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Funding

This work was supported by National Key R&D Program of China(grant number: 2018YFC1004303), National Natural Science Foundation Project of China (grant number: 82160154, 81670844), the Hundred-level Innovative Talent Foundation of Guizhou Province (grant number: QKH-PTRC-GCC[2023]041), the Science and Technology Foundation of Guizhou Province (grant number: QKH-PTRC-2018- 5772–042), the Science and Technology Foundation of Guizhou Provincial Health Commission (grant number: gzwkj2022-268), the Project of Development Research Center of Guizhou Provincial Dendrobium Industry (grant number: QSKH [2019003013]), the Training Program Foundation for Young Talents of Zunyi Medical University (grant number: QKH-PTRC-2021–035) and the Program for Excellent Young Talents of Zunyi Medical University (grant number: 18-ZY-001).

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Authors and Affiliations

  1. Department of Immunology, Special Key Laboratory of Ocular Diseases of Guizhou Province, Zunyi Medical University, Zunyi, Guizhou, P.R. China

    Yuelin Hu, Jialing Huang, Shuqing Wang & Hongsong Yu

  2. School of Basic Medical Sciences, Special Key Laboratory of Gene Detection and Therapy of Guizhou Province, Zunyi Medical University, Zunyi, Guizhou, P.R. China

    **n Sun & **n Wang

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  1. Yuelin Hu
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  3. Shuqing Wang
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  4. **n Sun
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  5. **n Wang
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  6. Hongsong Yu
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Contributions

Hongsong Yu conceived the idea. Yuelin Hu drafted the manuscript and searched the literatures. Jialing Huang, Shuqing Wang, **n Sun and **n Wang participated in the manuscript preparation and revised it critically for important intellectual content. Final approval of the version was submitted by all authors.

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Correspondence to Hongsong Yu.

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Hu, Y., Huang, J., Wang, S. et al. Deciphering Autoimmune Diseases: Unveiling the Diagnostic, Therapeutic, and Prognostic Potential of Immune Repertoire Sequencing. Inflammation (2024). https://doi.org/10.1007/s10753-024-02079-2

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  • DOI: https://doi.org/10.1007/s10753-024-02079-2

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