SpringerLink
Log in

New Triterpenoid and Anti-Inflammatory Constituents of Eriobotrya deflexa f. deflexa

  • Published:
Chemistry of Natural Compounds Aims and scope

    We’re sorry, something doesn't seem to be working properly.

    Please try refreshing the page. If that doesn't work, please contact support so we can address the problem.

A new triterpenoid, methyl 2α-(4-hydroxybenzoyl)oxy-3β-hydroxy-urs-12-en-28-oate (1), has been isolated from the leaves of Eriobotrya deflexa f. deflexa, together with five known compounds, quercetin (2), kaempferol 3-O-β-glucoside (3), naringenin (4), ursolic acid (5), and euscaphic acid (6). The structure of new compound 1 was determined through spectroscopic and MS analyses. Among the isolates, quercetin (2), naringenin (4), and ursolic acid (5) showed potent inhibition with IC50 values of 31.74 ± 1.87, 24.25 ± 1.68, and 18.05 ± 1.02 μM, respectively, against LPS-induced NO generation.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Subscribe and save

Springer+ Basic
EUR 32.99 /Month
  • Get 10 units per month
  • Download Article/Chapter or Ebook
  • 1 Unit = 1 Article or 1 Chapter
  • Cancel anytime
Subscribe now

Buy Now

Price includes VAT (France)

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. H. Ohashi, Rosaceae in Flora of Taiwan, Vol. 3, 2nd Ed., Editorial Committee of the Flora of Taiwan, Taipei, Taiwan, 1993, pp. 69–157.

    Google Scholar 

  2. J. J. Chen, R. F. Wu, J. W. Hsiao, L. C. Chen, T. F. Zhu, Y. H. Kuo, P. J. Sung, M. J. Cheng, and T. C. Chang, Chem. Nat. Compd., 55, 74 (2019).

    Article  CAS  Google Scholar 

  3. N. De Tommasi, F. De Simone, C. Pizza, N. Mahmood, N. Orsi, and M. L. Stein, J. Nat. Prod., 55, 1067 (1992).

    Article  Google Scholar 

  4. T. Kikuchi, H. Akazawa, K. Tabata, A. Manosroi, J. Manosroi, T. Suzuki, and T. Akihisa, Chem. Pharm. Bull., 59, 378 (2011).

    Article  CAS  Google Scholar 

  5. T. Uto, A. Sakamoto, N. H. Tung, T. Fujiki, K. Kishihara, S. Oiso, H. Kariyazono, O. Morinaga, and Y. Shoyama, Int. J. Mol. Sci., 14, 4106 (2013).

    Article  CAS  Google Scholar 

  6. K. N. Rashed and M. Butnariu, Adv. Pharm. Bull., 4, 75 (2014).

    CAS  PubMed  Google Scholar 

  7. N. De Tommasi, F. De Simone, R. Aquino, C. Pizza, and Z. Z. Liang, J. Nat. Prod., 53, 810 (1990).

    Article  Google Scholar 

  8. N. De Tommasi, R. Aquino, F. De Simone, and C. Pizza, J. Nat. Prod., 55, 1025 (1992).

    Article  Google Scholar 

  9. C. W. Fang, L. C. Chen, H. C. Huang, T. H. Chang, C. L. Chen, M. J. Cheng, and J. J. Chen, Chem. Nat. Compd., 55, 821 (2019).

    Article  CAS  Google Scholar 

  10. F. S. Wu, C. J. Hung, C. L. Lin, T. H. Chang, C. L. Chen, P. J. Sung, M. J. Cheng, H. Y. Huang, and J. J. Chen, Chem. Nat. Compd., 56, 1000 (2020).

    Article  CAS  Google Scholar 

  11. A. Numata, P. Yang, C. Takahashi, R. Fujiki, M. Nabae, and E. Fujita, Chem. Pharm. Bull., 37, 648 (1989).

    Article  CAS  Google Scholar 

  12. M. Johansson, B. Kopcke, H. Anke, and O. Sterner, J. Antibiot., 55, 104 (2002).

    Article  CAS  Google Scholar 

Download references

ACKNOWLEDGMENT

This research was supported by a grant from the Ministry of Science and Technology, Taiwan (MOST 109-2320-B-010-029-MY3) awarded to Prof. J.-J. Chen. This work was also supported by grants from **tung Christian Hospital (PS 110030) and Cardinal Tien Junior College of Health and Management (CTCN-110-02). We gratefully thank Ms Shou-Ling Huang and Dr. Iren Wang for assistance in the NMR experiments at the Instrumentation Center at NTU, which is supported by the Ministry of Science and Technology, Taiwan. Hui-Ming Chen and Chien-Ming Huang have contributed equally to this manuscript.

Author information

Authors and Affiliations

  1. Department of Nursing, Cardinal Tien Junior College of Health and Management, 231, New Taipei City, Taiwan

    Hui-Ming Chen

  2. Division of Pharmacy, Cheng Hsin General Hospital, 112, Taipei, Taiwan

    Chien-Ming Huang

  3. Department of Pharmacy, Tajen University, 907, Yanpu Township, **tung, Taiwan

    Li-Chai Chen

  4. Department of Pharmacy, School of Pharmaceutical Sciences, National Yang Ming Chiao Tung University, 112, Taipei, Taiwan

    Chang-Syun Yang & Jih-Jung Chen

  5. Institute of Microbiology and Immunology, National Defense Medical Center, 114, Taipei, Taiwan

    Tsung-Hsien Chang

  6. Department of Biological Sciences, National Sun Yat-Sen University, 804, Kaohsiung, Taiwan

    Chun-Lin Chen

  7. National Museum of Marine Biology and Aquarium, 944, Checheng Township, **tung, Taiwan

    **-Jyun Sung

  8. Chung-Jen College of Nursing, Health Sciences and Management, 600, Chiayi, Taiwan

    Wen-Lung Kuo

  9. Bioresource Collection and Research Center (BCRC), Food Industry Research and Development Institute (FIRDI), 300, Hsinchu, Taiwan

    Ming-Jen Cheng

  10. Department of Pharmacy, **tung Christian Hospital, 900, **tung City, **tung, Taiwan

    Jen-Wen Hsiao

  11. Department of Medical Research, China Medical University Hospital, China Medical University, 404, Taichung, Taiwan

    Jih-Jung Chen

Authors
  1. Hui-Ming Chen
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Chien-Ming Huang
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Li-Chai Chen
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Chang-Syun Yang
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Tsung-Hsien Chang
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Chun-Lin Chen
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. **-Jyun Sung
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. Wen-Lung Kuo
    View author publications

    You can also search for this author in PubMed Google Scholar

  9. Ming-Jen Cheng
    View author publications

    You can also search for this author in PubMed Google Scholar

  10. Jen-Wen Hsiao
    View author publications

    You can also search for this author in PubMed Google Scholar

  11. Jih-Jung Chen
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Jih-Jung Chen.

Additional information

Published in Khimiya Prirodnykh Soedinenii, No. 3, May–June, 2022, pp. 424–427.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Chen, HM., Huang, CM., Chen, LC. et al. New Triterpenoid and Anti-Inflammatory Constituents of Eriobotrya deflexa f. deflexa. Chem Nat Compd 58, 496–500 (2022). https://doi.org/10.1007/s10600-022-03718-6

Download citation

  • Received:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10600-022-03718-6

Keywords

Search

Navigation