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A New Isochroman Derivative from the Marine Fungus Phomopsis sp. (No. Gx-4)

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Chemistry of Natural Compounds Aims and scope

A new isochroman, (3R,4S)-3,4-dihydro-8-hydroxy-4-methoxy-3-methylisocoumarin (1), and three known compounds were isolated from the marine fungus Phomopsis sp. (No. Gx-4). Their structures were determined by spectroscopic methods, mainly 1D and 2D NMR. Primary bioassays and preliminary pharmacological tests revealed that compounds 1 and 3 can accelerate the growth of subintestinal vessel plexus (SIV) branches markedly, but compounds 2 and 4 can inhibit their growth.

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Acknowledgment

We thank Prof. Lifu Wu and Dr. Jie Yuan for providing pharmacological data. This research was supported by the National Natural Science Foundation of China (20772162, 20972197) and the Department of Education Scientific Research Project of Guangxi Province (201204LX497).

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Authors and Affiliations

  1. Key Laboratory of Plant Resources Conservation and Sustainable Utilization, South China Botanical Garden, Chinese Academy of Sciences, 510650, Guangzhou, P. R. China

    Jian **ang Yang & Sheng**ang Qiu

  2. School of Chemistry and Chemical Engineering, Sun Yat-Sen University, 510275, Guangzhou, P. R. China

    Zhigang She & Yongcheng Lin

  3. Department of Chemistry and Engineering, Guilin Normal College, Guilin, 541002, Guangxi, China

    Jian **ang Yang

Authors
  1. Jian **ang Yang
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  2. Sheng**ang Qiu
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  3. Zhigang She
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  4. Yongcheng Lin
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Corresponding authors

Correspondence to Jian **ang Yang or Sheng**ang Qiu.

Additional information

Published in Khimiya Prirodnykh Soedinenii, No. 3, May–June, 2014, pp. 367–369.

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Yang, J.X., Qiu, S., She, Z. et al. A New Isochroman Derivative from the Marine Fungus Phomopsis sp. (No. Gx-4). Chem Nat Compd 50, 424–426 (2014). https://doi.org/10.1007/s10600-014-0976-y

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  • DOI: https://doi.org/10.1007/s10600-014-0976-y

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