Abstract
Lung cancer continues to attract special attention since the real number of lung cancer mortality and incidence in 2014 was definitely higher than those estimated numbers according to the report from World Health Organization. The present special issue highly focuses on advanced discovery and development of lung cancer and metastasis and discusses about potential opportunities and challenges to be faced. The present issue explores clinical applications of cancer immunotherapies, gene therapies, radiotherapies, or target-oriented therapies. A new and novel methodology can be used to identify differential interactions of driver genes, cancer-predictive genes, subtype-specific genes, or disease-exclusive genes or gene pairs from imbalanced or heterogeneous datasets. We also demonstrate the importance of lung cancer-specific gene mutations, epigenetics, gene sequencing, heterogeneity, or biomarker discovery. Clinical bioinformatics is emphasized as a critical tool and merging science. Novel therapies are designed and expected on basis of oncogenic molecular aberrations in lung cancer.
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References
Smith, R. A., Manassaram-Baptiste, D., Brooks, D., Doroshenk, M., Fedewa, S., Saslow, D., Brawley, O. W., & Wender, R. (2015). Cancer screening in the United States, 2015: A review of current American Cancer Society guidelines and current issues in cancer screening. CA: A Cancer Journal for Clinicians, 65(1), 30–54. doi:10.3322/caac.21261.
Ferlay, J., Soerjomataram, I., Dikshit, R., Eser, S., Mathers, C., Rebelo, M., Parkin, D. M., Forman, D., & Bray, F. (2015). Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012. International Journal of Cancer, 136(5), E359–E386. doi:10.1002/ijc.29210.
Weiner, L. M., Murray, J. C., & Shuptrine, C. W. (2012). Antibody-based immunotherapy of cancer. Cell, 148(6), 1081–1084. doi:10.1016/j.cell.2012.02.034.
Salama, J. K., & Schild S. E. (2015). Radiation therapy for oligometastatic non-small cell lung cancer. Cancer & Metastasis Review.
Leder, K., Pitter, K., Laplant, Q., Hambardzumyan, D., Ross, B. D., Chan, T. A., Holland, E. C., & Michor, F. (2014). Mathematical modeling of PDGF-driven glioblastoma reveals optimized radiation dosing schedules. Cell, 156(3), 603–616. doi:10.1016/j.cell.2013.12.029.
de Bruin, E. C., McGranahan, N., Mitter, R., Salm, M., Wedge, D. C., Yates, L., et al. (2014). Spatial and temporal diversity in genomic instability processes defines lung cancer evolution. Science, 346(6206), 251–256. doi:10.1126/science.1253462.
Zhang, J., Fujimoto, J., Zhang, J., Wedge, D. C., Song, X., Zhang, J., et al. (2014). Intratumor heterogeneity in localized lung adenocarcinomas delineated by multiregion sequencing. Science, 346(6206), 256–259. doi:10.1126/science.1256930.
Wu, D. J., Wang, X. D. (2015). Application of clinical bioinformatics in lung cancer-specific biomarkers. Cancer & Metastasis Review.
Mehta, A., Romero-Olmedo, A. J., Dobersch S., Barreto G. (2015). Significance of epigenetics in lung cancer diagnosis and therapy. Cancer & Metastasis Review.
Dolsten, M., & Søgaard, M. (2012). Precision medicine: an approach to R&D for delivering superior medicines to patients. Clinical and Translational Medicine, 1, 7. doi:10.1186/2001-1326-1-7.
Landesman-Milo, D., Ramishetti, S., Peer, D. (2015). Nanomedicine as an emerging platform for metastatic lung cancer therapy. Cancer & Metastasis Review.
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Wang, X., Adjei, A.A. Lung cancer and metastasis: new opportunities and challenges. Cancer Metastasis Rev 34, 169–171 (2015). https://doi.org/10.1007/s10555-015-9562-4
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DOI: https://doi.org/10.1007/s10555-015-9562-4