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Phenotypical Characteristics of Chemically Induced Mammary Tumor

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The histological and immunohistochemical type of chemically induced (injection of N-methyl-N-nitrosourea into the mammary gland) breast tumor was studied in Wistar females. The tumor induced by N-methyl-N-nitrosourea was moderately differentiated adenocarcinoma with infiltrative growth lacking estrogen-α and human epidermal growth factor receptors, and expressing progesterone receptors; tumor cells were characterized by high proliferative activity. This variant of chemically induced breast tumor corresponds to human breast cancer luminal type B.

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Authors and Affiliations

  1. Research Institute of Clinical and Experimental Lymphology, Novosibirsk, Russia

    A. V. Kabakov, A. P. Lykov, D. V. Morozov, O. V. Kazakov, A. F. Poveshchenko, T. V. Raiter, D. N. Strunkin & V. I. Konenkov

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  1. A. V. Kabakov
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  2. A. P. Lykov
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  3. D. V. Morozov
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  4. O. V. Kazakov
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  5. A. F. Poveshchenko
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  6. T. V. Raiter
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  7. D. N. Strunkin
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  8. V. I. Konenkov
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Correspondence to A. V. Kabakov.

Additional information

Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 163, No. 4, pp. 490-493, April, 2017

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Kabakov, A.V., Lykov, A.P., Morozov, D.V. et al. Phenotypical Characteristics of Chemically Induced Mammary Tumor. Bull Exp Biol Med 163, 490–492 (2017). https://doi.org/10.1007/s10517-017-3835-6

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  • DOI: https://doi.org/10.1007/s10517-017-3835-6

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