Abstract
Improving AIDS Care after Trauma (ImpACT), a co** intervention for HIV-infected women with sexual abuse histories, was evaluated for feasibility and potential efficacy in a public clinic in Cape Town, South Africa. Sixty-four participants were enrolled prior to starting antiretroviral therapy (ART). After completing baseline assessments, participants were randomly assigned to standard of care (SoC: three adherence counseling sessions) or ImpACT (SoC plus four individual and three group sessions). Participants completed assessments at 3 months (after individual sessions) and 6 months post-baseline. In exploratory analysis of primary outcomes, ImpACT participants, compared to SoC, reported greater reductions in avoidance and arousal symptoms of PTSD and greater increases in ART adherence motivation at 3 months. Clinically significant decreases in overall PTSD symptoms were also demonstrated at 3 months. These effects continued as trends at the 6-month assessment, in addition to increases in social/spiritual co**. In analysis of secondary outcomes, high levels of non-adherence to ART and poor care engagement were evident at 6 months, with no differences between study arms. A trauma-focused, culturally-adapted individual intervention delivered by a non-specialist in the HIV care setting is feasible and acceptable. Preliminary findings suggest ImpACT has potential to reduce PTSD symptoms and increase ART adherence motivation, but a more intensive intervention may be needed to improve and maintain care engagement among this population. Trial Registration: ClinicalTrials.gov NCT02223390.
![](http://media.springernature.com/m312/springer-static/image/art%3A10.1007%2Fs10461-017-2013-1/MediaObjects/10461_2017_2013_Fig1_HTML.gif)
Similar content being viewed by others
References
Seedat S. Interventions to improve psychological functioning and health outcomes of HIV-infected individuals with a history of trauma or PTSD. Curr HIV/AIDS Rep. 2012;9(4):344–50.
Machtinger E, Wilson T, Haberer J, Weiss D. Psychological trauma and PTSD in HIV-positive women: a meta-analysis. AIDS Behav. 2012;16(8):2091–100.
LeGrand S, Reif S, Sullivan K, Murray K, Barlow ML, Whetten K. A review of recent literature on trauma among individuals living with HIV. Curr HIV/AIDS Rep. 2015;12(4):397–405.
Whetten K, Shirey K, Pence BW, Yao J, Thielman N, Whetten R, et al. Trauma history and depression predict incomplete adherence to antiretroviral therapies in a low income country. PLoS ONE. 2013;8(10):e74771.
Aaron E, Criniti S, Bonacquisti A, Geller PA. Providing sensitive care for adult HIV-infected women with a history of childhood sexual abuse. J Assoc Nurses AIDS Care. 2013;24(4):355–67.
Hatcher AM, Smout EM, Turan JM, Christofides N, Stockl H. Intimate partner violence and engagement in HIV care and treatment among women: a systematic review and meta-analysis. Aids. 2015;29(16):2183–94.
Applebaum AJ, Bedoya CA, Hendriksen ES, Wilkinson JL, Safren SA, O’Cleirigh C. Future directions for interventions targeting PTSD in HIV-infected adults. J Assoc Nurses AIDS Care. 2015;26(2):127–38.
McLean CP, Fitzgerald H. Treating posttraumatic stress symptoms among people living with HIV: a critical review of intervention trials. Curr Psychiatry Rep. 2016;18(9):83.
Pacella ML, Armelie A, Boarts J, Wagner G, Jones T, Feeny N, et al. The impact of prolonged exposure on PTSD symptoms and associated psychopathology in people living with HIV: a randomized test of concept. AIDS Behav. 2012;16(5):1327–40.
Sikkema KJ, Ranby KW, Meade CS, Hansen NB, Wilson PA, Kochman A. Reductions in traumatic stress following a co** intervention were mediated by decreases in avoidant co** for people living with HIV/AIDS and childhood sexual abuse. J Consult Clin Psychol. 2013;81(2):274–83.
Nemeroff CB, Bremner JD, Foa EB, Mayberg HS, North CS, Stein MB. Posttraumatic stress disorder: a state-of-the-science review. J Psychiatr Res. 2006;40(1):1–21.
Folkman S, Chesney M, McKusick L, Ironson G, Johnson D, Coates T. Translating co** theory into an intervention. In: Eckenrode J, editor. The social context of co**. New York, NY: Plenum Press; 1991. p. 239–60.
UNAIDS. UNAIDS data 2017. Geneva, Switzerland: Joint United Nations Programme on HIV/AIDS; 2017
Jewkes R, Penn-Kekana L, Levin J, Ratsaka M, Schrieber M. Prevalence of emotional, physical and sexual abuse of women in three South African provinces. S Afr Med J. 2001;91(5):421–8.
Yemeke TT, Sikkema KJ, Watt MH, Ciya N, Robertson C, Joska JA. Screening for traumatic experiences and mental health distress among women in HIV care in Cape Town, South Africa. J Interpers Violence. 2017:0886260517718186.
Whetten K, Reif S, Whetten R, Murphy-McMillan LK. Trauma, mental health, distrust, and stigma among HIV-positive persons: implications for effective care. Psychosom Med. 2008;70(5):531–8.
Blashill AJ, Perry N, Safren SA. Mental health: a focus on stress, co**, and mental illness as it relates to treatment retention, adherence, and other health outcomes. Curr HIV/AIDS Rep. 2011;8(4):215–22.
Watt MH, Dennis AC, Choi KW, Ciya N, Joska JA, Robertson C, et al. Impact of sexual trauma on HIV care engagement: perspectives of female patients with trauma histories in Cape Town, South Africa. AIDS Behav. 2017;21(11):3209–18.
McIntosh R, Rosselli M. Stress and co** in women living with HIV: a meta-analytic review. AIDS Behav. 2012;16(8):2144–59.
Keuroghlian AS, Kamen CS, Neri E, Lee S, Liu R, Gore-Felton C. Trauma, dissociation, and antiretroviral adherence among persons living with HIV/AIDS. J Psychiatr Res. 2011;45(7):942–8.
Dallam S. Where does it hurt? How victimization impacts presentation and outcomes in primary care. In: Banyard VL, Edwards VJ, Kendall-Tackett K, editors. Trauma and physical health: understanding the effects of extreme stress and of psychological harm. London and New York: Routledge; 2009. p. 134–62.
Pence BW, Mugavero MJ, Carter TJ, Leserman J, Thielman NM, Raper JL, et al. Childhood trauma and health outcomes in HIV-infected patients: an exploration of causal pathways. J Acquir Immune Defic Syndr. 2012;59(4):409–16.
Brief DJ, Bollinger AR, Vielhauer MJ, Berger-Greenstein JA, Morgan EE, Brady SM, et al. Understanding the interface of HIV, trauma, post-traumatic stress disorder, and substance use and its implications for health outcomes. AIDS Care. 2004;16(Suppl 1):S97–120.
Kessler RC, Berglund P, Demler O, ** R, Merikangas KR, Walters EE. Lifetime prevalence and age-of-onset distributions of DSM-IV disorders in the National Comorbidity Survey Replication. Arch Gen Psychiatry. 2005;62(6):593–602.
Seedat S, Stein DJ, Carey PD. Post-traumatic stress disorder in women: epidemiological and treatment issues. CNS Drugs. 2005;19(5):411–27.
Ironson G, O’Cleirigh C, Fletcher MA, Laurenceau JP, Balbin E, Klimas N, et al. Psychosocial factors predict CD4 and viral load change in men and women with human immunodeficiency virus in the era of highly active antiretroviral treatment. Psychosom Med. 2005;67(6):1013–21.
Reilly KH, Clark RA, Schmidt N, Benight CC, Kissinger P. The effect of post-traumatic stress disorder on HIV disease progression following hurricane Katrina. AIDS Care. 2009;21(10):1298–305.
Schafer KR, Brant J, Gupta S, Thorpe J, Winstead-Derlega C, Pinkerton R, et al. Intimate partner violence: a predictor of worse HIV outcomes and engagement in care. AIDS Patient Care STDS. 2012;26(6):356–65.
Leserman J, Pence B, Whetten K, Mugavero M, Thielman N, Swartz M, et al. Relation of lifetime trauma and depressive symptoms to mortality in HIV. Am J Psychiatry. 2007;164(11):1707–13.
Campbell JC, Baty ML, Ghandour RM, Stockman JK, Francisco L, Wagman J. The intersection of intimate partner violence against women and HIV/AIDS: a review. Int J Injury Control Saf Promot. 2008;15(4):221–31.
Brezing C, Ferrara M, Freudenreich O. The syndemic illness of HIV and trauma: implications for a trauma-informed model of care. Psychosomatics. 2015;56(2):107–18.
Machtinger EL, Cuca YP, Khanna N, Rose CD, Kimberg LS. From treatment to healing: the promise of trauma-informed primary care. Womens Health Issues. 2015;25(3):193–7.
Sales JM, Swartzendruber A, Phillips AL. Trauma-informed HIV prevention and treatment. Curr HIV/AIDS Rep. 2016;13(6):374–82.
Onu C, Ongeri L, Bukusi E, Cohen CR, Neylan TC, Oyaro P, et al. Interpersonal psychotherapy for depression and posttraumatic stress disorder among HIV-positive women in Kisumu, Kenya: study protocol for a randomized controlled trial. Trials. 2016;17:64.
Opiyo E, Ongeri L, Rota G, Verdeli H, Neylan T, Meffert S. Collaborative interpersonal psychotherapy for HIV-positive women in Kenya: a case study from the mental health, hiv and domestic violence (MIND) study. J Clin Psychol. 2016;72(8):779–83.
Patel V. The future of psychiatry in low- and middle-income countries. Psychol Med. 2009;39(11):1759–62.
Petersen I, Lund C, Stein DJ. Optimizing mental health services in low-income and middle-income countries. Curr Opin Psychiatry. 2011;24(4):318–23. https://doi.org/10.1097/YCO.0b013e3283477afb.
Statistics South Africa. South African National Census of 2011. Pretoria, South Africa: Government of South Africa; 2011.
Department of Health. National consolidated guidelines for the prevention of mother-to-child transmission of HIV (PMTCT) and the management of hiv in children, adolsecents and adults. South Africa: Pretoria; 2015.
World Health Organization. Composite international diagnostic interview (CIDI), Version 1.0. Geneva: WHO; 1990.
Bernstein DP, Stein JA, Newcomb MD, Walker E, Pogge D, Ahluvalia T, et al. Development and validation of a brief screening version of the Childhood Trauma Questionnaire. Child Abuse Negl. 2003;27(2):169–90.
Lecrubier Y, Sheehan D, Weiller E, Amorim P, Bonora I, Harnett Sheehan K, et al. The Mini International Neuropsychiatric Interview (MINI). A short diagnostic structured interview: reliability and validity according to the CIDI. Eur Psychiatry. 1997;12(5):224–31.
Browne RH. On the use of a pilot sample for sample size determination. Stat Med. 1995;14(17):1933–40.
Eldridge SM, Chan CL, Campbell MJ, Bond CM, Hopewell S, Thabane L, et al. CONSORT 2010 statement: extension to randomised pilot and feasibility trials. BMJ (Clinical research ed). 2016;355:i5239.
Sikkema KJ, Wilson PA, Hansen NB, Kochman A, Neufeld S, Ghebremichael MS, et al. Effects of a co** intervention on transmission risk behavior among people living with HIV/AIDS and a history of childhood sexual abuse. J Acquir Immune Defic Syndr. 2008;47(4):506–13.
Meade CS, Drabkin AS, Hansen NB, Wilson PA, Kochman A, Sikkema KJ. Reductions in alcohol and cocaine use following a group co** intervention for HIV-positive adults with childhood sexual abuse histories. Addiction. 2010;105(11):1942–51.
Sikkema KJ, Joska JA, Choi KW, Robertson C, Ciya N, Knettel BA, et al. ImpACT: improving AIDS care after trauma—intervention manual. Duke University and University of Cape Town; 2017.
Bush K, Kivlahan DR, McDonell MB, Fihn SD, Bradley KA. The AUDIT alcohol consumption questions (AUDIT-C): an effective brief screening test for problem drinking. Ambulatory Care Quality Improvement Project (ACQUIP). Alcohol Use Disorders Identification Test. Arch Intern Med. 1998;158(16):1789–95.
Kotze M, Visser M, Makin J, Sikkema K, Forsyth B. Psychosocial variables associated with co** of HIV-positive women diagnosed during pregnancy. AIDS Behav. 2013;17(2):498–507.
Straus MA, Hamby SL, Boney-McCoy S, Sugarman DB. The revised Conflict Tactics Scales (CTS2): development and preliminary psychometric data. J Fam Issues. 1996;17(3):283–316.
Blevins CA, Weathers FW, Davis MT, Witte TK, Domino JL. The Posttraumatic Stress Disorder Checklist for DSM-5 (PCL-5): development and initial psychometric evaluation. J Trauma Stress. 2015;28(6):489–98.
Namir S, Wolcott DL, Fawzey FI, Alumbaugh MJ. Co** with AIDS: psychological and health implications. J Appl Soc Psychol. 1987;17(3):309–28.
Kotze M, Visser M, Makin J, Sikkema K, Forsyth B. The co** strategies used over a two-year period by HIV-positive women who had been diagnosed during pregnancy. AIDS Care. 2013;25(6):695–701.
Olley BO, Zeier MD, Seedat S, Stein DJ. Post-traumatic stress disorder among recently diagnosed patients with HIV/AIDS in South Africa. AIDS Care. 2005;17(5):550–7.
Carver CS. You want to measure co** but your protocol’s too long: consider the brief COPE. Int J Behav Med. 1997;4(1):92–100.
Hansen NB, Harrison B, Fambro S, Bodnar S, Heckman TG, Sikkema KJ. The structure of co** among older adults living with HIV/AIDS and depressive symptoms. J Health Psychol. 2013;18(2):198–211.
Folkman S, Lazarus RS. Manual for the ways of co** questionnaire. Research ed. Palo Alto, CA: Consulting Psychological Press; 1988.
The LifeWindows Project Team. The LifeWindows Information Motivation Behavioral Skills ART Adherence Questionnaire (LW-IMB-AAQ). Center for Health, Intervention, and Prevention. University of Connecticut; 2006.
Chesney MA, Ickovics JR, Chambers DB, Gifford AL, Neidig J, Zwickl B, et al. Self-reported adherence to antiretroviral medications among participants in HIV clinical trials: the AACTG adherence instruments. Patient Care Committee & Adherence Working Group of the Outcomes Committee of the Adult AIDS Clinical Trials Group (AACTG). AIDS Care. 2000;12(3):255–66.
Mugavero MJ, Westfall AO, Zinski A, Davila J, Drainoni ML, Gardner LI, et al. Measuring retention in HIV care: the elusive gold standard. J Acquir Immune Defic Syndr. 2012;61(5):574–80.
World Health Organization. Consolidated guidelines on person-centred HIV patient monitoring and case surveillance. Geneva: WHO; 2017.
Harris PA, Taylor R, Thielke R, Payne J, Gonzalez N, Conde JG. Research electronic data capture (REDCap)–a metadata-driven methodology and workflow process for providing translational research informatics support. J Biomed Inform. 2009;42(2):377–81.
Weathers FW, Litz BT, Keane TM, Palmieri PA, Marx BP, Schnurr PP. The PTSD Checklist for DSM-5 (PCL-5) 2013 (Scale available from the National Center for PTSD at www.ptsd.va.gov).
Bass JK, Annan J, McIvor Murray S, Kaysen D, Griffiths S, Cetinoglu T, et al. Controlled trial of psychotherapy for Congolese survivors of sexual violence. N Engl J Med. 2013;368(23):2182–91.
Singer M, Bulled N, Ostrach B, Mendenhall E. Syndemics and the biosocial conception of health. Lancet. 2017;389(10072):941–50.
Meyer JP, Springer SA, Altice FL. Substance abuse, violence, and HIV in women: a literature review of the syndemic. J Women’s Health. 2011;20(7):991–1006.
Grimsrud A, Bygrave H, Doherty M, Ehrenkranz P, Ellman T, Ferris R, et al. Reimagining HIV service delivery: the role of differentiated care from prevention to suppression. J Int AIDS Soc. 2016;19(1):21484.
Rueda S, Park-Wyllie LY, Bayoumi A, Tynan A-M, Antoniou T, Rourke S, et al. Patient support and education for promoting adherence to highly active antiretroviral therapy for HIV/AIDS. Cochrane Database Syst Rev. 2006(3).
Hembree EA, Foa EB, Dorfan NM, Street GP, Kowalski J, Tu X. Do patients drop out prematurely from exposure therapy for PTSD? J Trauma Stress. 2003;16(6):555–62.
World Health Organization. Consolidated guidelines on the use of antiretroviral drugs for treating and preventing HIV infection. Geneva: WHO; 2016.
Department of Health. Minister Aaron Motsoaledi: Health Dept Budget Vote 2016/17. 2016.
UNAIDS. Prevention Gap Report. Geneva, Switzerland: Joint United Nations Programme on HIV/AIDS; 2016.
Takuva S, Brown AE, Pillay Y, Delpech V, Puren AJ. The continuum of HIV care in South Africa: implications for achieving the second and third UNAIDS 90-90-90 targets. AIDS. 2017;31(4):545–52.
Acknowledgements
This study was funded by a Grant from NIMH (R34 MH102001). We also acknowledge support received from the Duke Center for AIDS Research (P30 AI064518), and the Duke Interdisciplinary Research Training Program in AIDS (T32 AI007392). We gratefully acknowledge the participants who contributed time and energy to this study.
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Conflict of interest
All authors declare that they have no conflict of interest.
Ethical Approval
All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards. (Duke C0147, UCT 071/2014).
Informed Consent
Informed consent was obtained from all individual participants included in the study.
Rights and permissions
About this article
Cite this article
Sikkema, K.J., Mulawa, M.I., Robertson, C. et al. Improving AIDS Care After Trauma (ImpACT): Pilot Outcomes of a Co** intervention Among HIV-Infected Women with Sexual Trauma in South Africa. AIDS Behav 22, 1039–1052 (2018). https://doi.org/10.1007/s10461-017-2013-1
Published:
Issue Date:
DOI: https://doi.org/10.1007/s10461-017-2013-1