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Mild renal dysfunction causes aggravated cardiac damage in type 2 diabetic patients: a comprehensive echocardiography study

  • Original Article–Cardiology
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Abstract

Purpose

We sought to detect left ventricular (LV) adverse alterations in structure and function in type 2 diabetes mellitus (T2DM) patients with or without mild renal dysfunction (MRD) using comprehensive echocardiography techniques and to explore the independent risk factors for LV remodeling (LVR) and dysfunction in these patients.

Methods

The study included 82 T2DM patients with normal LV ejection fraction (presence (n = 42)/absence (n = 40) of MRD). Age- and gender-matched controls (n = 40) were also recruited. LV structure and function were evaluated using conventional echocardiography and three-dimensional speckle tracking echocardiography (3DSTE). Global longitudinal strain (GLS), global circumferential strain (GCS), global area strain (GAS), and global radial strain (GRS) were all measured using 3DSTE.

Results

Compared with the controls with absolute advantage of LV normal geometry, LVR was more frequently present in the two T2DM groups, with the largest proportion in those with T2DM and MRD (P < 0.001). Fasting plasma glucose (FPG) and MRD were both significant risk factors for LVR in T2DM patients.

The detection rates of LV diastolic dysfunction and subclinical systolic dysfunction were significantly higher in the T2DM groups than in the controls (P = 0.000). Moreover, the two case groups also showed significantly lower strain values in multiple directions than the controls (all P < 0.05). FPG was significantly associated with LV diastolic dysfunction, whereas FPG and MRD were both significantly associated with subclinical LV systolic dysfunction in T2DM patients.

Conclusions

The combined use of conventional echocardiography and 3DSTE allowed the timely detection of early cardiac damage in T2DM patients with or without MRD.

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Authors and Affiliations

  1. Department of Ultrasound, Affiliated Hospital of Southwest Medical University, Luzhou, China

    Qingqing Wang

  2. Department of Public Health, Evangelismos Private Hospital, Luzhou, China

    **a Tao

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  1. Qingqing Wang
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  2. **a Tao
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Correspondence to Qingqing Wang.

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Qingqing Wang and **a Tao declare that there are no conflicts of interest.

Ethical approval

The study was approved by the local ethics committee and the institutional review board (IRB) of our hospital in accordance with the Declaration of Helsinki. All study subjects or their guardians signed written informed consent prior to enrollment.

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Wang, Q., Tao, X. Mild renal dysfunction causes aggravated cardiac damage in type 2 diabetic patients: a comprehensive echocardiography study. J Med Ultrasonics (2024). https://doi.org/10.1007/s10396-024-01456-6

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  • DOI: https://doi.org/10.1007/s10396-024-01456-6

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