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C18-Free Organic–Inorganic Hybrid Silica Particles Derived from Sole Silsesquioxane for Reversed-Phase HPLC

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Abstract

Ethyl-bridged organic–inorganic hybrid silica particles were prepared via a sol–gel and hydrothermal synthesis approach using 1,2-bis(triethoxysilyl)ethane (BTESE) as the sole precursor, and triblock copolymer poly(ethylene oxide)-block-poly(propylene oxide)-block-poly(ethylene oxide) (P123) and dodecyltrimethylammonium bromide (DTAB) as combined templates. The morphology, pore structure, chemical composition and liquid chromatographic performance of the obtained materials were investigated in detail. The particles exhibit a high surface area of 1136.40 m2/g, together with a pore volume of 0.39 cm3/g and an average pore size of 2.30 nm. Used as stationary phase for high-performance liquid chromatography (HPLC), the particles without extra bonding either C18 or C8 can successfully separate a mixture of uracil, phenol, pyridine, methylbenzene, ethylbenzene and tert-butylbenzene. The obtained materials also show practical application in the separation of phthalate acid esters (PAEs), which are harmful to environment and human health. Although the columns packed with ethyl-bridged organic–inorganic hybrid silica show lower column efficiency and peak symmetry compared to commercial column, they have considerably higher chemical stability in alkaline mobile phase. The HSS column also possesses high mechanical stability which is similar to that of the commercial column.

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Acknowledgements

This research was financially supported by Scientific Research Common Program of the Bei**g Municipal Commission of Education (Grant No. KZ201410005006), National Natural Science Foundation of China (Grant Nos. 21171014, 50502002, 51402007), Bei**g Natural Science Foundation of China (Grant No. 2141001), State Key Laboratory of Solid Waste Reuse for Building Materials (Grant No. SWR-2014-010), and Funding Project for Academic Human Resources Development in Institutions of Higher Learning Under the Jurisdiction of Bei**g Municipality.

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Authors and Affiliations

  1. College of Materials Science and Engineering, Bei**g University of Technology, 100 **leyuan, Chaoyang District, Bei**g, 100124, People’s Republic of China

    Shi-Hao Peng, **u-Yun Yue, Ya-Li Wang, Qi Wei, Su-** Cui, Zuo-Ren Nie & Qun-Yan Li

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  1. Shi-Hao Peng
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  2. **u-Yun Yue
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  3. Ya-Li Wang
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  4. Qi Wei
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  5. Su-** Cui
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  7. Qun-Yan Li
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Correspondence to Qi Wei or Su-** Cui.

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Peng, SH., Yue, XY., Wang, YL. et al. C18-Free Organic–Inorganic Hybrid Silica Particles Derived from Sole Silsesquioxane for Reversed-Phase HPLC. Chromatographia 81, 247–256 (2018). https://doi.org/10.1007/s10337-017-3428-6

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