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Anti-biofilm effects of sinomenine against Staphylococcus aureus

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A Correction to this article was published on 22 October 2022

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Abstract

Staphylococcus aureus is a gram-positive foodborne pathogen capable of forming strong biofilms. This study identified that anti-biofilm natural compound against S. aureus. Sinomenine, a natural compound, showed significantly reduced biofilm formation (31.97–39.86%), but no effect on bacterial growth was observed. The dispersion of preformed biofilms was observed by confocal laser scanning microscopy (CLSM). qRT-PCR revealed that sinomenine treatment significantly up-regulated agrA by 3.8-fold and down-regulated icaA gene by 3.1-fold. These indicate that sinomenine treatment induces biofilm dispersal due to cell-cell adhesion, polysaccharide intercellular adhesin (PIA), and phenol-soluble modulin (PSM) peptides production. Our results suggest that sinomenine can be used as a promising agent for effectively controlling biofilm formation and dispersion, thereby making S. aureus more susceptible to the action of antimicrobial agents.

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Acknowledgements

This research was supported by Korea National Open University Research Fund.

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Authors and Affiliations

  1. Department of Food Science and Technology, College of Agriculture and Life Sciences, Chungnam National University, Daejeon, 34134, Korea

    Su-** Yum & Hee Gon Jeong

  2. Division of Human Ecology, Korea National Open University, Seoul, 03087, Korea

    Seung Min Kim

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  1. Su-** Yum
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  2. Hee Gon Jeong
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Yum, SJ., Jeong, H.G. & Kim, S.M. Anti-biofilm effects of sinomenine against Staphylococcus aureus. Food Sci Biotechnol 32, 83–90 (2023). https://doi.org/10.1007/s10068-022-01174-0

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