Abstract
Crimean-Congo hemorrhagic fever (CCHF) is a viral zoonotic disease which is endemic in Iran. The etiological agent of CCHF is an RNA virus belonging to the genus Nairovirus of the family Bunyaviridae. CCHF virus (CCHFV) can be transmitted to humans through bites from infected ticks and direct contact with infected blood or tissues. Although the disease has been observed in different age groups, the rate of disease is lower in children and elderly. This study was designed to characterize CCHFV-infected children in Iran. Between 2000 and 2016, a total of 908 CCHF suspected cases (in children less than 19 years old) were evaluated for CCHFV infection by CCHF IgM ELISA and RT-PCR. CCHFV infection was observed in 161 (17.73%) of subjects. Most CCHF positive children were male (70.8%) and >15 years of age (65.8%). Contact with livestock was the main risk factor (35.4%). Sistan and Baluchestan provinces had the highest frequency within the infected cohort (68.3%). The overall mortality rate was 11.8%. This study also revealed a significant reduction in CCHF-fatality rates in Iranian children when compared to earlier studies in Iran. Having contact with livestock was the major risk factor and CCHF was more common in male children of an older age.
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References
Bente DA, Forrester NL, Watts DM, McAuley AJ, Whitehouse CA, Bray M (2013) Crimean-Congo hemorrhagic fever: history, epidemiology, pathogenesis, clinical syndrome and genetic diversity. Antiviral Res 100:159–189
Chinikar S, Mazaheri V, Mirahmadi R, Nabeth P, Saron MF, Salehi P, Hosseini N, Bouloy M, Mirazimi A, Lundkvist A (2005) A serological survey in suspected human patients of Crimean-Congo hemorrhagic fever in Iran by determination of IgM specific ELISA method during 2000–2004. Arch Iran Med 8:52–55
Chinikar S (2009) An overview of Crimean-Congo hemorrhagic fever in Iran. Iran J Microbiol 1:7–12
Chinikar S, Ghiasi SM, Hewson R, Moradi M, Haeri A (2010) Crimean-Congo hemorrhagic fever in Iran and neighboring countries. J Clin Virol 47:110–114
Chinikar S, Ghiasi SM, Moradi M, Goya MM, Shirzadi MR, Zeinali M, Meshkat M, Bouloy M (2010) Geographical distribution and surveillance of Crimean-Congo hemorrhagic fever in Iran. Vector-Borne Zoonotic Dis 10:705–708
Chinikar S, Ghiasi SM, Moradi M, Goya MM, Shirzadi MR, Zeinali M, Meshkat M, Bouloy M (2010) Geographical distribution and surveillance of Crimean-Congo hemorrhagic fever in Iran. Vector Borne Zoonotic Dis 10:705–708
Dilber E, Cakir M, Acar EA, Orhan F, Yaris N, Bahat E, Okten A, Erduran E (2009) Crimean-Congo haemorrhagic fever among children in north-eastern Turkey. Ann Trop Paediatr 29:23–28
Duran A, Kucukbayrak A, Ocak T, Hakyemez NI, Tathorn T, Karadad M, Mengelodlu ZF (2013) Evaluation of patients with Crimean-Congo hemorrhagic fever in Bolu, Turkey. Afr Health Sci 13:233–242
Fazlalipour M, Baniasadi V, Mirghiasi SM, Jalali T, Khakifirouz S, Azad-Manjiri S, Mahmoodi V, Naderi HR, Zarandi R, Salehi-Vaziri M (2016) Crimean-Congo hemorrhagic fever due to consumption of raw meat: a case reports from East-North of Iran. Jpn J Infect Dis 69:270–271
Mardani M, Keshtkar-Jahromi M (2007) Crimean-Congo hemorrhagic fever. Arch Iran Med 10:204–214
Mardani M, Rahnavardi M, Sharifi-Mood B (2010) Current treatment of Crimean-Congo hemorrhagic fever in children. Expert Rev Anti Infect Ther 8:911–918
Salehi-Vaziri M, Baniasadi V, Jalali T, Mirghiasi SM, Azad-Manjiri S, Zarandi R, Mohammadi T, Khakifirouz S, Fazlalipour M (2016) The first fatal case of Crimean-Congo hemorrhagic fever due to AP92 like strain of Crimean-Congo hemorrhagic fever virus. Jpn J Infect Dis 69:344–346
Sharifi-Mood B, Mardani M, Keshtkar-Jahromi M, Rahnavardi M, Hatami H, Metanat M (2008) Clinical and epidemiologic features of Crimean-Congo hemorrhagic fever among children and adolescents from southeastern Iran. Pediatr Infect Dis J 27:561–563
Tezer H, Sucakli IA, Sayli TR, Celikel E, Yakut I, Kara A, Tunc B, Ergonul O (2010) Crimean-Congo hemorrhagic fever in children. J Clin Virol 48:184–186
Tuygun N, Tanir G, Caglayik DY, Uyar Y, Korukluoglu G, Cenesiz F (2012) Pediatric cases of Crimean-Congo hemorrhagic fever in Turkey. Pediatr Int 54:402–406
Yilmaz GR, Buzgan T, Irmak H, Safran A, Uzun R, Cevik MA, Torunoglu MA (2009) The epidemiology of Crimean-Congo hemorrhagic fever in Turkey, 2002–2007. Int J Infect Dis 13:380–386
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All procedures performed in this project involving human cases were in accordance with the ethical standards of the Ethical Committee of Science and Research Branch, Islamic Azad University and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.
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Aslani, D., Salehi-Vaziri, M., Baniasadi, V. et al. Crimean-Congo hemorrhagic fever among children in Iran. Arch Virol 162, 721–725 (2017). https://doi.org/10.1007/s00705-016-3162-7
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DOI: https://doi.org/10.1007/s00705-016-3162-7