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A comprehensive review of adult onset spinal teratomas: analysis of factors related to outcomes and recurrences

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Abstract

Purpose

Spinal teratomas are rare tumours noted in adults and are commonly located in the thoracolumbar region. Currently, there appears to be a lack of clear consensus regarding the management and prognosis of these lesions. A comprehensive review along with an illustrative case managed at the author’s institute has been presented.

Materials and methods

Online database search was performed for literature review.

Results

A 26-year-old male presented with acute onset neurological deficits and imaging revealed features of conus teratoma. Subtotal resection was performed and patient achieved fair recovery. Including the present one, a total of 146 cases have been reported and were analysed. Mean age was 39.6 years (range 18–85 years) and males predominated. Limb weakness and backache were the commonest symptoms. Majority of the lesions were intramedullary and located in the thoracolumbar region. Complete resection (CR) was achieved in 45% of cases. All, except one, were mature teratomas. Recurrences were noted in nine (6.1%) cases. Outcome was good/excellent in 86 (60%) and fair/poor in 26 (18%) cases. The presence of pain, absence of limb weakness and CR were significantly associated with good outcomes. Furthermore, subtotal resection (STR) had significantly higher recurrence rates than CR. Four deaths (2.7%) were noted.

Conclusions

Total surgical resection is the standard treatment and appears to be beneficial both in terms of outcomes and recurrences. Overall, recurrences are rare and may be managed by re-surgery. In addition, the present report is the eighth case of adult spinal teratoma with an acute onset presentation.

Graphic abstract

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References

  1. Sharma MC, Jain D, Sarkar C, Suri V, Garg A, Singh M, Mahapatra AK, Sharma BS (2009) Spinal teratomas: a clinico-pathological study of 27 patients. Acta Neurochir (Wien) 151:245–252

    Google Scholar 

  2. Ak H, Ulu MO, Sar M, Albayram S, Aydin S, Uzan M (2006) Adult intramedullary mature teratoma of the spinal cord: review of the literature illustrated with an unusual example. Acta Neurochir (Wien) 148:663–669

    CAS  Google Scholar 

  3. Li Y, Yang B, Song L, Yan D (2013) Mature teratoma of the spinal cord in adults: an unusual case. Oncol Lett 6:942–946

    PubMed  PubMed Central  Google Scholar 

  4. Gowers WR, Horsley V (1888) A case of tumour of the spinal cord. Removal; Recovery. Med Chir Trans 71(377–430):11

    PubMed  Google Scholar 

  5. Frick K (1911) Ube rein Teratoma des Ruckenmarks. Frankfurt Z Path 7:127–134

    Google Scholar 

  6. Kubie LS, Fulton JF (1928) A clinical and pathological study of two teratomatous cysts of the spinal cord, containing mucous and ciliated cells. Surg Gynec Obstet 47:297–311

    Google Scholar 

  7. Hosoi K (1931) Intradural teratoid tumors of the spinal cord: report of a case. Arch Pathol 11:875–883

    Google Scholar 

  8. Naffiziger HG, Jones OW (1935) Dermoid tumors of the spinal cord. Report of four cases with observations on a clinical test for the differentiation of the source of radicular pains. Arch Neurol Psychiat 33:941–958

    Google Scholar 

  9. Adams RD, Wegener W (1947) Congenital cyst of the spinal meninges as cause of intermittent compression of the spinal cord. Arch Neurol Psychiat 58:57–69

    CAS  PubMed  Google Scholar 

  10. Sullivan BH (1948) Intraspinal teratoma with report of a case. Brooklyn Hosp 6:142–145

    CAS  Google Scholar 

  11. Furtado D, Marques V (1951) Spinal teratoma. J Neuropathol Clin Neurol 10:384–393

    CAS  PubMed  Google Scholar 

  12. Dereymacker A (1954) Medullar compression by congenital tumors or cysts. Acta Neurol Belg 54:874–889

    Google Scholar 

  13. Bakay L (1956) Case records of the Massachusetts general hospital: case 42502. N Engl J Med 266:1153–1157

    Google Scholar 

  14. Teng P, Gordon J (1958) Teratoma of the conus medullaris: report of a case. J Neurosurg 15:569–571

    CAS  PubMed  Google Scholar 

  15. Sloof JL, Kernohan JW, MacCarty CS (1964) Primary intramedullary tumors of the spinal cord and filum terminale. Saunders, Philadelphia, pp 1–20

    Google Scholar 

  16. Rewcastle NB, Francoeur J (1964) Teratomatous cysts of the spinal canal; with “sex chromatin” studies. Arch Neurol 11:91–99

    CAS  PubMed  Google Scholar 

  17. Hansebout RR, Bertrand G (1965) Intraspinal teratoma simulating protruded intervertebral disc. J Neurosurg 22:374–379

    CAS  PubMed  Google Scholar 

  18. Reddy DR, Prabhakar V, Rao BD (1971) Intraspinal teratoma. Neurol India 19:45–47

    CAS  PubMed  Google Scholar 

  19. Eneström S, von Essen C (1977) Spinal teratoma. Acta Neurochir (Wien) 39:121–126

    Google Scholar 

  20. Rosenbaum TJ, Soule EH, Onofrio BM (1978) Teratomatous cyst of the spinal canal: case report. J Neurosurg 49:292–297

    CAS  PubMed  Google Scholar 

  21. Garrison JE, Kasdon DL (1980) Intramedullary spinal teratoma: case report and review of the literature. Neurosurgery 7:509–512

    CAS  PubMed  Google Scholar 

  22. Padovani R, Tognetti F, Sanpaolo P, Pozzati E, Gaist G, Kuba I (1982) Intramedullary cystic teratoma. Acta Neurochir (Wien) 62:101–108

    CAS  Google Scholar 

  23. Padovani R, Tognetti F, Laudadio S, Manetto V (1983) Teratoid cyst of the spinal cord. Neurosurgery 13:74–77

    CAS  PubMed  Google Scholar 

  24. Garza-Mercado R (1983) Diastematomyelia and intramedullary epidermoid spinal cord tumor combined with extradural teratoma in an adult: case report. J Neurosurg 58:954–958

    CAS  PubMed  Google Scholar 

  25. Nakayama K, Miyasaka Y, Matsumori K, Beppu T, Asao T (1983) Spinal teratoma. Report of an elderly case. Neurol Med Chir (Tokyo) 23:963–967

    CAS  Google Scholar 

  26. Conti P, Conti R, De Luca G (1984) Observations on some rare cases of vertebro-medullar malformations associated with tumors. J Neurosurg Sci 28:81–87

    CAS  PubMed  Google Scholar 

  27. Ironside JW, Jefferson AA, Royds JA, Taylor CB, Timperley WR (1984) Carcinoid tumour arising in a recurrent intradural spinal teratoma. Neuropathol Appl Neurobiol 10:479–489

    CAS  PubMed  Google Scholar 

  28. Smoker WR, Biller J, Moore SA, Beck DW, Hart MN (1986) Intradural spinal teratoma: case report and review of the literature. AJNR Am J Neuroradiol 7:905–910

    CAS  PubMed  Google Scholar 

  29. Giacomini P, Lunardi P, Liccardo G, Paris L, Sancesario G (1986) Cystic cervico-dorso-lumbar teratoma. Riv Neurol 56:1–8

    CAS  PubMed  Google Scholar 

  30. Monajati A, Spitzer RM, Wiley JL, Heggeness L (1986) MR imaging of a spinal teratoma. J Comput Assist Tomogr 10:307–310

    CAS  PubMed  Google Scholar 

  31. Pelissou-Guyotat I, Sindou M, Pialat J, Goutelle A (1988) Intramedullary mature teratoma associated with an attached cord and an intradural lipoma. Apropos of a surgically treated case. Review of the literature. Neurochirurgie 34:205–209

    CAS  PubMed  Google Scholar 

  32. Hamabuchi M, Hasegawa R, Murase T (1989) Teratoma of the spinal cord. A case report with CT scans. J Bone Joint Surg Br 71:390–392

    CAS  PubMed  Google Scholar 

  33. Üstün ME, Erdoğan A, Avunduk MC (1992) A case of cervical spinal teratoma associated with dermal sinus tract: MRI and surgical findings. Turk Neurosurg 2:194–198

    Google Scholar 

  34. Kaji S (1993) An elderly case of spinal teratoma in conus medullaris region. Seikeigeka 44:1359–1361 (in Japanese)

    Google Scholar 

  35. Nicoletti GF, Passanisi M, Platania N, Lanzafame S, Albanese V (1994) Intramedullary spinal cystic teratoma of the conus medullaris with caudal exophytic development: case report. Surg Neurol 41:106–111

    CAS  PubMed  Google Scholar 

  36. Eide PK, Skullerud K (1994) Teratoma of the medullary cone as a cause of peripheral polyneuropathy. Tidsskr Nor Laegeforen 114:1185–1186 (in Norwegian)

    CAS  PubMed  Google Scholar 

  37. Caruso R, Antonelli M, Cervoni L, Salvati M (1996) Intramedullary teratoma: case report and review of the literature. Tumori 82:616–620

    CAS  PubMed  Google Scholar 

  38. Koen JL, McLendon RE, George TM (1998) Intradural spinal teratoma: evidence for a dysembryogenic origin. Report of four cases. J Neurosurg 89:844–851

    CAS  PubMed  Google Scholar 

  39. Al-Sarraj ST, Parmar D, Dean AF, Phookun G, Bridges LR (1998) Clinicopathological study of seven cases of spinal cord teratoma: a possible germ cell origin. Histopathology 32:51–56

    CAS  PubMed  Google Scholar 

  40. Poeze M, Herpers MJ, Tjandra B, Freling G, Beuls EA (1999) Intramedullary spinal teratoma presenting with urinary retention: case report and review of the literature. Neurosurgery 45:379–385

    CAS  PubMed  Google Scholar 

  41. Natarajan M (1999) Conus medullaris teratoma presenting as myokymia. Neurol India 47:251

    CAS  PubMed  Google Scholar 

  42. Bloch I, Varga Z, Benini A (1999) Teratoma of the conus medullaris. J Clin Neurosci 6:249–252

    CAS  PubMed  Google Scholar 

  43. Allsopp G, Sgouros S, Barber P, Walsh AR (2000) Spinal teratoma: is there a place for adjuvant treatment? Two cases and a review of the literature. Br J Neurosurg 14:482–488

    CAS  PubMed  Google Scholar 

  44. Okuyama K, Abe E, Hoshi N, Misawa A, Tamura Y, Chiba M (2000) Dumb-bell-type teratoma in the lumbar spine. Skelet Radiol 29:104–108

    CAS  Google Scholar 

  45. Arai Y, Takahashi M, Takeda K, Shitoto K (2000) Adult-onset intradural spinal teratoma in the lumbar spine: a case report. J Orthop Surg (Hong Kong) 8:69–74

    Google Scholar 

  46. Fan X, Turner JE, Turner TM, Elrod JP, Clough JA, Howell EI, Johnson MD (2001) Carcinoid tumor development in an intramedullary spinal cord mature teratoma. AJNR Am J Neuroradiol 22:1778–1781

    CAS  PubMed  Google Scholar 

  47. Elmaci I, Dagcinar A, Ozgen S, Ekinci G, Pamir MN (2001) Diastematomyelia and spinal teratoma in an adult: case report. Neurosurg Focus 10:ecp2

    CAS  PubMed  Google Scholar 

  48. Nonomura Y, Miyamoto K, Wada E, Hosoe H, Nishimoto H, Ogura H, Shimizu K (2002) Intramedullary teratoma of the spine: report of two adult cases. Spinal Cord 40:40–43

    CAS  PubMed  Google Scholar 

  49. Hejazi N, Witzmann A (2003) Spinal intramedullary teratoma with exophytic components: report of two cases and review of the literature. Neurosurg Rev 26:113–116

    PubMed  Google Scholar 

  50. Maiuri F, Gangemi M, Cavallo LM, De Divitiis E (2003) Dysembryogenetic spinal tumours in adults without dysraphism. Br J Neurosurg 17:234–238

    CAS  PubMed  Google Scholar 

  51. Fernandez-Cornejo VJ, Martinez-Perez M, Polo-Garcia LA, Martinez-Lage JF, Poza M (2004) Cystic mature teratoma of the filum terminale in an adult. Case report and review of the literature. Neurocirugia (Astur) 15:290–293

    CAS  Google Scholar 

  52. Ates O, Cayli SR, Koçak A, Alkan A, Onal C, Usta U (2005) Mature spinal teratoma associated with thickened filum terminale. Neurol Med Chir (Tokyo) 45:375–378

    Google Scholar 

  53. Kao TH, Shen CC, Chen CC, Kwan PH (2005) Primary Benign retroperitoneal and intraspinal dumbbell-shaped cystic teratoma. Spine (Phila Pa 1976) 30:E439–E443

    Google Scholar 

  54. Kumar V, Peng EW, Kurian KM, Smith C, Fitzpatrick MO, Whittle IR (2006) An unusual progression of benign thoracic spinal cord teratoma in pregnancy: a hormonally-mediated pathway? Br J Neurosurg 20:106–108

    CAS  PubMed  Google Scholar 

  55. Stevens QE, Kattner KA, Chen YH, Rahman MA (2006) Intradural extramedullary mature cystic teratoma: not only a childhood disease. J Spinal Disord Tech 19:213–216

    PubMed  Google Scholar 

  56. Paterakis KN, Karantanas AH, Barbanis S, Hadjigeorgiou GM, Karavelis A (2006) Cervical spinal cord intramedullary teratoma. Clin Neurol Neurosurg 108:514–517

    PubMed  Google Scholar 

  57. Kahilogullari G, Erdem A, Heper AO, Erden E (2006) Intramedullary mature cystic teratoma of the conus medullaris. A case report. J Neurosurg Sci 50:55–58

    CAS  PubMed  Google Scholar 

  58. Tsitsopoulos P, Rizos C, Isaakidis D, Liapi G, Zymaris S (2006) Coexistence of spinal intramedullary teratoma and diastematomyelia in an adult. Spinal Cord 44:632–635

    CAS  PubMed  Google Scholar 

  59. Caruso R, Colonnese C (2006) Intramedullary teratomas: two case reports and a review of the literature. Zentralbl Neurochir 67:213–218

    CAS  PubMed  Google Scholar 

  60. Makary R, Wolfson D, Dasilva V, Mohammadi A, Shuja S (2007) Intramedullary mature teratoma of the cervical spinal cord at C1-2 associated with occult spinal dysraphism in an adult. Case report and review of the literature. J Neurosurg Spine 6:579–584

    PubMed  Google Scholar 

  61. Mut M, Shaffrey ME, Bourne TD, Jagannathan J, Shaffrey CI (2007) Unusual presentation of an adult intramedullary spinal teratoma with diplomyelia. Surg Neurol 67:190–194

    PubMed  Google Scholar 

  62. Sung KS, Sung SK, Choi HJ, Song YJ (2008) Spinal intradural extramedullary mature cystic teratoma in an adult. J Korean Neurosurg Soc 44:334–337

    PubMed  PubMed Central  Google Scholar 

  63. Mohindra S, Chhabra R, Gupta R, Dass Radotra B (2008) Cystic, exophytic teratoma of conus medullaris presenting with chronic renal failure. Surg Neurol 69:81–83

    PubMed  Google Scholar 

  64. Han IH, Kuh SU, Chin DK, Kim KS, ** BH, Cho YE (2008) Surgical treatment of primary spinal tumors in the conus medullaris. J Korean Neurosurg Soc 44:72–77

    PubMed  PubMed Central  Google Scholar 

  65. Benes V III, Barsa P, Mikulastik J, Suchomel P (2009) Exophytic intramedullary mature teratoma of the conus medullaris: case report and review of the literature. Cent Eur Neurosurg 70:154–160

    PubMed  Google Scholar 

  66. Ijiri K, Hida K, Yano S, Iwasaki Y (2009) Huge intradural ossification caused by a mature spinal teratoma: case report. Neurosurgery 64:E1200–E1201

    PubMed  Google Scholar 

  67. Ghostine S, Perry E, Vaynman S, Raghavan R, Tong KA, Samudrala S, Johnson JP, Colohan A (2009) The rare case of an intramedullary cervical spinal cord teratoma in an elderly adult: case report and literature review. Spine (Phila Pa) 34:E973–E978

    Google Scholar 

  68. Gu W, Shang H, ** X, **e J, Zhao W (2010) Intradural lumbar mature teratoma with neuronal and glial tissue component in an adult. Case report. Neurol Med Chir (Tokyo) 50:1112–1115

    Google Scholar 

  69. Arvin B, Pohl U, David K (2009) Intramedullary cervical teratoma in an adult. Spine J 9:e14–e18

    PubMed  Google Scholar 

  70. Jeong SJ, Youm JY, Choi SW, Kim SH (2009) Intradural mature teratoma in the lumbar spine found in adult. Korean J Spine 6:211–213

    Google Scholar 

  71. Oh JS, Im SB, Kim BT, Shin WH (2009) Surgical findings of a lumbar mature teratoma accompanying the preoperative intracranial dissemination of Fatty droplets. Korean Neurosurg Soc 46:409–412

    Google Scholar 

  72. Moon HJ, Shin BK, Kim JH, Kim JH, Kwon TH, Chung HS, Park YK (2010) Adult cervical intramedullary teratoma: first reported immature case. J Neurosurg Spine 13:283–287

    PubMed  Google Scholar 

  73. Agrawal M, Uppin MS, Patibandla MR, Bhattacharjee S, Panigrahi MK, Saradhi V, Rani JY, Purohit AK, Challa S (2010) Teratomas in central nervous system: a clinico-morphological study with review of literature. Neurol India 58:841–846

    PubMed  Google Scholar 

  74. Jian W, Ying W, Chao Y (2010) Intramedullary spinal teratoma of the conus medullaris: report of two cases. Acta Neurochir (Wien) 152:553–554

    Google Scholar 

  75. Yu J, Qu LM, Li Y, Huang H (2012) Coexistence of spinal teratoma of the conus medullaris and arteriovenous malformation in an adult: a case report. Turk Neurosurg 22:510–514

    PubMed  Google Scholar 

  76. Maiti T, Bhat DI, Devi BI, Sampath S, Mahadevan A, Shankar SK (2010) Teratoma in split cord malformation: an unusual association: a report of two cases with a review of the literature. Pediatr Neurosurg 46:238–241

    PubMed  Google Scholar 

  77. Conti P, Tenenbaum R, Capozza M, Mouchaty H, Conti R (2010) Diastematomyelia and tumor in adults: report of two cases and literature review. Spine (Phila Pa 1976) 35:E1438–E1443

    Google Scholar 

  78. Bouaziz M, Haouam K, Laouar O, Lankar A (2011) A case of cervical intradural extramedullary mature cystic teratoma: diagnosis and management. Neurochirurgie 57:88–91

    CAS  PubMed  Google Scholar 

  79. Musil J, Mrlian A, Duba M, Kren L, Smrcka M (2011) Probably the oldest patient with the diagnosis of medullar conus teratoma. Bratisl Lek Listy 112:357–359

    CAS  PubMed  Google Scholar 

  80. Ben Nsir A, Hammouda KB, Said IB, Kassar AZ, Kchir N, Jemel H (2015) Spinal intradural mature teratoma in an elderly patient. J Cancer Metastasis Treat 1:106–110

    Google Scholar 

  81. Garg A, Arora V, Vaishy S, Sinha LK (2012) Chemical meningitis caused by spontaneous rupture of spinal teratoma. J Assoc Phys India 60:54–56

    Google Scholar 

  82. Kalani MY, Iyer S, Coons SW, Smith KA (2012) Spinal intradural teratomas: developmental programs gone awry? Neurosurg Focus 33:E1

    PubMed  Google Scholar 

  83. Jiang H, **ao Z, Zhan X, Chen Q, He M, Lu L (2013) Unusual association of intraspinal extramedullary teratoma with congenital scoliosis in an elderly adult: case report and literature review. Eur Spine J 22(Suppl 3):S306–S310

    PubMed  Google Scholar 

  84. Vanguardia MK, Honeybul S, Robbins P (2014) Subtotal resection of an intradural mature teratoma in an adult presenting with difficulty initiating micturition. Surg Neurol Int 25(5):23

    Google Scholar 

  85. Babu R, Reynolds R, Moreno JR, Cummings TJ, Bagley CA (2014) Concurrent split cord malformation and teratoma: dysembryology, presentation, and treatment. J Clin Neurosci 21:212–216

    PubMed  Google Scholar 

  86. Pandey S, Sharma V, Shinde N, Ghosh A (2015) Spinal intradural extramedullary mature cystic teratoma in an adult: a rare tumor with review of literature. Asian J Neurosurg 10:133–137

    PubMed  PubMed Central  Google Scholar 

  87. Alkherayf F, Arab AF, Tsai E (2015) Conus medullaris teratoma with utilization of fiber tractography: case report. J Neurol Surg Rep 76:e183–e187

    PubMed  PubMed Central  Google Scholar 

  88. Gunbey HP, Aslan K, Barıs YS, Incesu L (2015) Unusual presentation of a adult filum terminale teratoma associated with diplomyelia. Spine J 15:e49–e50

    PubMed  Google Scholar 

  89. Yılmaz B, Demir MK, Yapıcıer O, Toktaş ZO, Akakın A, Konya D (2015) Mature cystic teratoma of the lumbar spine without fat in the cystic cavity. Spine J 15:e43–e44

    PubMed  Google Scholar 

  90. Oh HS, Kim TW, Park KH (2015) Spinal teratoma concomitant with intracranial lipid droplet dissemination. Korean J Spine 12:15–18

    PubMed  PubMed Central  Google Scholar 

  91. Turan N, Halani SH, Baum GR, Neill SG, Hadjipanayis CG (2016) Adult intramedullary teratoma of the spinal cord: a case report and review of literature. World Neurosurg 87:661.e23–661.e30

    Google Scholar 

  92. Asan Z, Kaymaz H, Kilitci A (2017) Spinal intramedullary mature cystic teratoma in an adult. Br J Neurosurg 31:489–491

    PubMed  Google Scholar 

  93. Agay AK, Garg S, Hedaoo K (2016) Spinal intradural extramedullary mature cystic teratoma in young adult: a rare tumor with review of literature. Int J Res Med Sci 4:5481–5483

    Google Scholar 

  94. Ariñez Barahona E, Navarro Olvera JL, Esqueda Liquidano MA, Muñoz Cobos A, Gonzalez Echeverria KE, Rivera Arroyo AD et al (2016) A special case of intramedullary teratoma in an adult. Literature review. Rev Med Hosp Gen Mex. https://doi.org/10.1016/j.hgmx.2016.09.001

    Article  Google Scholar 

  95. Khazendar A, Hama Ameen HM, Jabbar NI, Hasan SO, Ahmed TS, Ali AA (2016) Upper lumbar mature cystic teratoma: a case report. World Neurosurg 96(609):e7–e11

    Google Scholar 

  96. Wang H, Huang Y, Nie P, Dong C, Hou F, Hao D, Xu W (2016) MRI findings in intraspinal mature teratoma. Clin Radiol 71:717.e1–717.e8

    CAS  Google Scholar 

  97. Schmidt RF, Casey JP, Gandhe AR, Curtis MT, Heller JE (2017) Teratoma of the spinal cord in an adult: report of a rare case and review of the literature. J Clin Neurosci 36:59–63

    PubMed  Google Scholar 

  98. Wan W, Yang C, Yan W, Liu T, Yang X, Song D, **ao J (2017) Adult-onset intradural spinal teratoma: report of 18 consecutive cases and outcomes in a single center. Eur Spine J 26:1917–1928

    PubMed  Google Scholar 

  99. Mohammadi A, Fereydouni T, Rahbari A, Mokarian P, Khademi Z (2017) Intradural intramedullary teratoma presenting in the lumbar spine: report of a rare case. World Neurosurg 106(1051):e5–e8

    Google Scholar 

  100. Lekgabe E, Rogers TW, Laidlaw J, Lui E, Gaillard F (2018) A case of conus medullaris teratoma. J Clin Neurosci 47:123–126

    PubMed  Google Scholar 

  101. Russell DS, Rubinstein LJ (1989) Pathology of tumors of the nervous system, 5th edn. Williams & Wilkins, Baltimore, pp 664–750

    Google Scholar 

  102. Ebner FH, Roser F, Acioly MA, Schoeber W, Tatagiba M (2009) Intramedullary lesions of the conus medullaris: differential diagnosis and surgical management. Neurosurg 32:287–301

    Google Scholar 

  103. Willis RA (1948) Pathology of tumours. Butterworth, London, pp 940–984

    Google Scholar 

  104. Park SC, Kim KJ, Wang KC, Choe G, Kim HJ (2010) Spinal epidural teratoma: review of spinal teratoma with consideration on pathogenesis: case report. Neurosurgery 67:E1818–E1825

    PubMed  Google Scholar 

  105. Tapper D, Lack E (1983) Teratomas in infancy and childhood. Ann Surg 198:388–410

    Google Scholar 

  106. Sawamura Y, Kato T, Ikeda J, Murata J, Tada M, Shirato H (1998) Teratomas of the central nervous system: treatment considerations based on 34 cases. J Neurosurg 89:728–737

    CAS  PubMed  Google Scholar 

  107. Ugarte N, Gonzalez-Crussi F, Sotelo-Avila C (1980) Diastematomyelia associated with teratomas. Report of two cases. J Neurosurg 53:720–725

    CAS  PubMed  Google Scholar 

  108. Norman D, Mills CM, Brant-Zawadzki M, Yeates A, Crooks LE, Kaufman L (1983) Magnetic resonance imaging of the spinal cord and canal: potentials and limitations. AJR Am J Roentgenol 141:1147–1152

    CAS  PubMed  Google Scholar 

  109. Daszkiewicz P, Roszkowski M, Przasnek S, Grajkowska W, Jurkiewicz E (2006) Teratoma or enterogenous cyst? The histopathological and clinical dilemma in co-existing occult neural tube dysraphism. Folia Neuropathol 44:24–33

    PubMed  Google Scholar 

  110. Bucy PC, Buchanan DN (1935) Teratoma of spinal cord. Surg Gynecol Obstet 60:1137–1144

    Google Scholar 

  111. Walter GF, Kleinert R (1987) Dysontogenetic brain tumours—proposal for an improved classification. Neuropathol Appl Neurobiol 13:273–287

    CAS  PubMed  Google Scholar 

  112. Valdiserri RO, Yunis EJ (1981) Sacrococcygeal teratomas. Cancer 48:217–221

    CAS  PubMed  Google Scholar 

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  1. Department of Neurosurgery, Kasturba Medical College, Manipal, Manipal Academy of Higher Education, Manipal, India

    G. Lakshmi Prasad

  2. Department of Orthodontics, Manipal College of Dental Sciences, Manipal, Manipal Academy of Higher Education, Manipal, India

    S. Divya

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Prasad, G.L., Divya, S. A comprehensive review of adult onset spinal teratomas: analysis of factors related to outcomes and recurrences. Eur Spine J 29, 221–237 (2020). https://doi.org/10.1007/s00586-019-06037-7

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