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Retrospective analysis of preoperative application of triple-modal pre-rehabilitation on postoperative recovery of colorectal cancer patients

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Abstract

Purpose

To retrospectively analyze the difference between triple-modal pre-rehabilitation and common treatment in patients with colorectal cancer (CRC).

Methods

A total of 145 patients with CRC diagnosed by pathology and admitted to our hospital for surgery between June 2020 and June 2022 were included in the study. All patients were divided into two groups: the triple-modal pre-rehabilitation group (pre-rehabilitation group) and the common treatment group. The triple-modal pre-rehabilitation strategy included exercise (3–5 times per week, with each session lasting more than 50 min), nutritional support, and psychological support. The study was designed to assess the potential of the pre-rehabilitation intervention to accelerate postoperative recovery by assessing the 6-min walk test, nutritional indicators, and HADS score before and after surgery.

Results

The pre-rehabilitation intervention did not reduce the duration of initial postoperative recovery or the incidence of postoperative complications, but it did increase the patients’ exercise capacity (as determined by the 6-min walk test), with the pre-rehabilitation group performing significantly better than the common group (433.0 (105.0) vs. 389.0 (103.5), P < 0.001). The study also found that triple-modal pre-rehabilitation was beneficial for the early recovery of nutritional status in surgical patients and improved anxiety and depression in patients after surgery, especially in those who had not received neoadjuvant therapy.

Conclusion

The triple-modal pre-rehabilitation strategy is of significant importance for reducing stress and improving the functional reserve of patients with colorectal cancer (CRC) during the perioperative period. The results of our study provide further support for the integration of the triple-modal pre-rehabilitation strategy into the treatment and care of CRC patients.

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Data availability

The authors will make the data available upon request.

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Authors and Affiliations

  1. Department of General Surgery, **ba District, Chongqing, 400037, People’s Republic of China

    **g-Qiong Huang, Ying **ao, Rong Wang, Lin-Tong Zhang, Dan Gu, **ang-Sheng Li, Cong Xu, Guang-Sheng Du & Wei-Dong **ao

  2. Nursing Department, **nqiao Hospital, Army Medical University, Chongqing, 400037, People’s Republic of China

    Ling Gu

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  1. **g-Qiong Huang
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Contributions

All authors contributed to the study conception and design. Material preparation, data collection and analysis were performed by **g-Qiong Huang, Ying **ao and Rong Wang. Ling Gu, Lin-Tong Zhang, Dan Gu and **ang-Sheng Li prepared the Tables 1–5. Cong Xu prepared the Fig. 1. The first draft of the manuscript was written by Cong XU and Guang-Sheng DU. Wei-Dong **ao was the leader of this team. All authors commented on previous versions of the manuscript.

Corresponding authors

Correspondence to Cong Xu, Guang-Sheng Du or Wei-Dong **ao.

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Ethics approval

This study was supported by the Ethics Committee of the Second Affiliated Hospital of the Army Military Medical University (2020–149-01) and performed in accordance with the ethical standards as laid down in the 1964 Declaration of Helsinki. All participants provided written informed consent.

Competing interests

The authors declare no competing interests.

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**g-Qiong Huang, Ying **ao, and Rong Wang contributed equally to this study.

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Huang, JQ., **ao, Y., Wang, R. et al. Retrospective analysis of preoperative application of triple-modal pre-rehabilitation on postoperative recovery of colorectal cancer patients. Support Care Cancer 32, 217 (2024). https://doi.org/10.1007/s00520-024-08423-4

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