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Association between high cytomegalovirus antibody titers and blood pressure in the adult Kazakh and Han Chinese populations

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Summary

Background

Human cytomegalovirus (CMV) has been linked to the pathogenesis of elevated arterial blood pressure (BP). Our study aimed to determine the association between anti-CMV titers and arterial BP in the Kazakh and Han Chinese populations.

Material and methods

Kazakh and Han (n = 800 each) (age, ≥18 years) subjects from **njiang, China were examined for anti-CMV immunoglobulin (Ig)G titers using a commercially available enzyme-linked immunosorbent assay (ELISA) kit. The highest anti-CMV titer tertiles determined within gender and ethnicity groups were compared against the two lower tertiles and seronegative samples.

Results

Multivariate linear regression analysis revealed that anti-CMV titers were independent determinants for elevated systolic (p = 0.006) BP in Kazakh women and inversely associated with systolic (p = 0.004) and mean arterial (p = 0.019) BP in Han women.

Conclusion

The association between CMV infection and/or resulting immune response and BP elevation differed by sex and ethnicity. In Kazakh women, they were associated with elevated BP and the opposite was true among Han women.

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References

  1. Murphy E, Shank TE. Human cytomegalovirus genome. In: Shenk TE, Stinski MF, editors. Human cytomegalovirus. Current topics in microbiology and immunology 325. Berlin Heidelberg: Springer; 2008. pp. 1–19.

    Google Scholar 

  2. Davison AJ, Dolan A, Akter P, Addison C, Dargan DJ, Alcendor DJ, MeGoch DJ, Hayward GS. The human cytomegalovirus genome revisited: comparison with the chimpanzee cytomegalovirus genome. J Gen Virol. 2003;84:17–28.

    Article  CAS  PubMed  Google Scholar 

  3. Reeves MB, MacAry PA, Lehner PJ, Sissons JG, Sinclair JH. Latency, chromatin remodeling, and reactivation of human cytomegalovirus in the dendritic cells of healthy carriers. Proc Natl Acad Sci USA. 2005;102:4140–5.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  4. Bentz GL, Jarquin-Pardo M, Chan G, Smith MS, Sinzger C, Yurochko AD. Human cytomegalovirus (CMV) infection of endothelial cells promotes naïve monocyte extravasation and transfer of productive virus to enhance hematogenous dissemination of CMV. J Virol. 2006;80:11539–55.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  5. Söderberg-Nauclér C. Does cytomegalovirus play a causative role in the development of various inflammatory diseases and cancer? J Intern Med. 2006;259:219–46.

    Article  PubMed  Google Scholar 

  6. Liu Z, Zhang P, Tang S, et al. Urine real-time polymerase chain reaction detection for children virus pneumonia with acute human cytomegalovirus infection. Bmc Infect Dis. 2014;14:245–54.

    Article  PubMed  PubMed Central  Google Scholar 

  7. Leeamornsiri S, Choopong P, Tesavibul N. Frosted branch angiitis as a result of immune recovery uveitis in a patient with cytomegalovirus retinitis. J Ophthalmic Inflamm Infect. 2013;3:1–4.

    Article  Google Scholar 

  8. Greenberg MS, Dubin G, Stewart JC, Cumming CG, MacGregor RR, Friedman HM. Relationship of oral disease to the presence of cytomegalovirus DNA in the saliva of AIDS patients. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 1995;79:175–9.

    Article  CAS  PubMed  Google Scholar 

  9. Dreher AM, Arora N, Fowler KB, Novak Z, Britt WJ, Boppana SB, Ross SA. Spectrum of disease and outcome in children with symptomatic congenital cytomegalovirus infection. J Pediatr. 2014;164:855–9.

    Article  PubMed  PubMed Central  Google Scholar 

  10. Cannon MJ, Schmid DS, Hyde TB. Review of cytomegalovirus seroprevalence and demographic characteristics associated with infection. Rev Med Virol. 2010;20:202–13.

    Article  PubMed  Google Scholar 

  11. Wang GC, Kao WH, Murakami P, et al. Cytomegalovirus infection and the risk of mortality and frailty in older women: a prospective observational cohort study. Am J Epidemiol. 2010;171:1144–52.

    Article  PubMed  PubMed Central  Google Scholar 

  12. Li C, Samaranayake NR, Ong KL, Wong HK, Cheung BM. Is human cytomegalovirus infection associated with hypertension? The United States National Health and Nutrition Examination Survey 1999–2002. PLOS ONE. 2012;7:e39760.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  13. Haarala A, Kähönen M, Lehtimäki T, et al. Relation of high cytomegalovirus antibody titres to blood pressure and brachial artery flow-mediated dilation in young men: the cardiovascular risk in young finns study. Clin Exp Immunol. 2012;167:309–16.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  14. Yao XG, Frommlet F, Zhou L, Zu F, Wang HM, Yan ZT, Luo WL, Hong J, Wang XL, Li NF. The prevalence of hypertension, obesity and dyslipidemia in individuals of over 30 years of age belonging to minorities from the pasture area of **njiang. BMC Public Health. 2010;10:91.

    Article  PubMed  PubMed Central  Google Scholar 

  15. Tang N, Li JW, Liu YM, et al. Human cytomegalovirus infection is association with essential hypertension in Kazakh and Han Chinese population. Med Sci Monit. 2014;20:2508–19.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  16. Cheng J, Ke Q, ** Z, Wang H, Kocher O, Morgan JP, Zhang J, Crumpacker CS. Cytomegalovirus infection causes an increase of arterial blood pressure. Plos Pathog. 2009;5:e1000427.

    Article  PubMed  PubMed Central  Google Scholar 

  17. Schieffer B, Luchtefeld M, Braun S, Hilfiker A, Hilfiker-Kleiner D, Drexler H. Role of NAD(P)H oxidase in angiotensin II-induced JAK/STAT signaling and cytokine induction. Circ Res. 2000;87:1195–201.

    Article  CAS  PubMed  Google Scholar 

  18. Li S, Zhu J, Zhang W, et al. Signature microRNA expression profile of essential hypertension and its novel link to human cytomegalovirus infection. Circulation. 2011;124:175–84.

    Article  CAS  PubMed  Google Scholar 

  19. Nieto FJ, Adam E, Sorlie P, Farzadegan H, Melnick JL, Comstock GW, Szklo M. Cohort study of cytomegalovirus infection as a risk factor for carotid intimal-medial thickening, a measure of subclinical atherosclerosis. Circulation. 1996;94:922–7.

    Article  CAS  PubMed  Google Scholar 

  20. Simanek AM, Dowd JB, Pawelec G, Melzer D, Dutta A, Aiello AE. Seropositivity to cytomegalovirus, inflammation, all-cause and cardiovascular disease-related mortality in the United States. PLOS ONE. 2011;6:e16103.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  21. Shen YH, Zhang L, Utama B, et al. Human cytomegalovirus inhibits Akt-mediated eNOS activation through upregulating PTEN (phosphatase and tensin homolog deleted on chromosome 10). Cardiovasc Res. 2006;69:502–11.

    Article  CAS  PubMed  Google Scholar 

  22. Weis M, Kledal TN, Lin KY, Panchal SN, Gao SZ, Valantine HA, Mocarski ES, Cooke JP. Cytomegalovirus infection impairs the nitric oxide synthase pathway: role of asymmetric dimethylarginine in transplant arteriosclerosis. Circulation. 2004;109:500–5.

    Article  CAS  PubMed  Google Scholar 

  23. Grahame-Clarke C, Chan NN, Andrew D, Ridgway GL, Betteridge DJ, Emery V, Colhoun HM, Vallance P. Human cytomegalovirus seropositivity is associated with impaired vascular function. Circulation. 2003;108:678–83.

    Article  PubMed  Google Scholar 

  24. Ward KP, Galloway WH, Auchterlonie IA. Congenital cytomegalovirus infection and diabetes. Lancet. 1979;1:497.

    Article  CAS  PubMed  Google Scholar 

  25. Smelt MJ, Faas MM, de Haan BJ, Draijer C, Hugenholtz GC, de Haan A, Engelse MA, de Koning EJ, de Vos P. Susceptibility of human pancreatic β cells for cytomegalovirus infection and the effects on cellular immunogenicity. Pancreas. 2012;41:39–49.

    Article  CAS  PubMed  Google Scholar 

  26. Basha B, Samuel SM, Triggle CR, Ding H. Endothelial dysfunction in diabetes mellitus: possible involvement of endoplasmic reticulum stress? Exp Diabetes Res. 2012;2012:481840.

    Article  PubMed  PubMed Central  Google Scholar 

  27. Zhu J, Shearer GM, Norman JE, Pinto LA, Marincola FM, Prasad A, Waclawiw MA, Csako G, Quyyumi AA, Epstein SE. Host response to cytomegalovirus infection as a determinant of susceptibility to coronary artery disease: sex-based differences in inflammation and type of immune response. Circulation. 2000;102:2491–6.

    Article  CAS  PubMed  Google Scholar 

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Acknowledgements

This project was funded by the Joint Funds of the National Natural Science Foundation of China (Grant No: U1403123) (HF), and the Applied Basic Research Youth Programs of Shihezi University, China (No: 2015ZRKXYQ-LH14).

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Authors and Affiliations

  1. Department of Pathophysiology/Key Laboratory of Education Ministry of **njiang Endemic and Ethnic Diseases, Medical College of Shihezi University, 832002, Shihezi, China

    Na Tang, Jia-Wei Li, Yong-Min Liu, Hua Zhong, La-Mei Wang, **g Hui, Yuan-Yuan Qu & Fang He

  2. Department of Pathology, Medical College of Chengdu University, 610000, Chengdu, China

    Feng-Mei Deng

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  1. Na Tang
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  2. Jia-Wei Li
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  3. Yong-Min Liu
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  4. Hua Zhong
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  6. Feng-Mei Deng
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  7. **g Hui
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  8. Yuan-Yuan Qu
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  9. Fang He
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Corresponding author

Correspondence to Fang He.

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Conflict of interest

N. Tang, J.-W. Li, Y.-M. Liu, H. Zhong, L.-M. Wang, F.-M. Deng, J. Hui, Y.-Y. Qu and F. He declare that they have no competing interests.

Additional information

Na Tang and Jia-Wei Li contributed equally to this work.

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Tang, N., Li, JW., Liu, YM. et al. Association between high cytomegalovirus antibody titers and blood pressure in the adult Kazakh and Han Chinese populations. Wien Klin Wochenschr 129, 709–716 (2017). https://doi.org/10.1007/s00508-017-1239-2

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