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Killer-cell immunoglobulin-like receptor and human leukocyte antigen-C genes in common variable immunodeficiency

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An Erratum to this article was published on 13 November 2015

Summary

Background

We aimed herein to investigate the killer-cell immunoglobulin-like receptor (KIR) genes and human leukocyte antigen (HLA)-C alleles in patients with common variable immunodeficiency (CVID), and to reveal their differences from those in healthy population.

Methods

In all, 18 patients who have been diagnosed with CVID and 15 living donors of kidney transplant recipients were enrolled in the study. Polymerase chain reaction-sequence-specific primer (PCR-SSP) ty** method was used in molecular genetic analysis. The frequencies of the genes in the study groups were statistically compared with each other using chi-square or Fisher exact tests, whichever were appropriate.

Results

Although there was no significant difference between both study groups with respect to distribution of KIR and HLA-C2 group genes, HLA-Cw7 allele frequency in patients with CVID was significantly lower than that in healthy population (P = 0.008).

Conclusion

This present study results support that HLA-Cw7 allele, an inhibitor of KIR ligand, may play a role in the pathogenesis of CVID.

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Conflict of interest

The authors declare that they have no conflict of interest.

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Authors and Affiliations

  1. Division of Immunology and Allergic Diseases, Gulhane Military Medical Academy and School of Medicine, 06018, Ankara, Turkey

    Ozgur Kartal MD,  Ugur Musabak, Sait Yesillik MD, Rahsan I. Sagkan, Aysel Pekel, Fevzi Demirel MD, Abdullah Baysan MD, Ali Selçuk MD,  Mustafa Güleç &  Osman Şener

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  1. Ozgur Kartal MD
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  2. Ugur Musabak
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  3. Sait Yesillik MD
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  4. Rahsan I. Sagkan
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  5. Aysel Pekel
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  6. Fevzi Demirel MD
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  7. Abdullah Baysan MD
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  8. Ali Selçuk MD
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  9. Mustafa Güleç
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  10. Osman Şener
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Corresponding author

Correspondence to Ozgur Kartal MD.

Additional information

An erratum to this article is available at http://dx.doi.org/10.1007/s00508-015-0894-4.

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Kartal, O., Musabak, U., Yesillik, S. et al. Killer-cell immunoglobulin-like receptor and human leukocyte antigen-C genes in common variable immunodeficiency. Wien Klin Wochenschr 128, 822–826 (2016). https://doi.org/10.1007/s00508-015-0769-8

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  • DOI: https://doi.org/10.1007/s00508-015-0769-8

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