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Biomarkers of acute kidney injury in pediatric cardiac surgery

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A Letter to the Editors to this article was published on 21 June 2021

Abstract

Acute kidney injury (AKI) is characterized by a sudden decrease in kidney function. Children with congenital heart disease are a special group at risk of develo** AKI. We performed a systematic review of the literature to search for studies reporting the usefulness of novel urine, serum, and plasma biomarkers in the diagnosis and progression of AKI and their association with clinical outcomes in children undergoing pediatric cardiac surgery. In thirty studies, we analyzed the capacity to predict AKI and poor outcomes of five biomarkers: Cystatin C, Neutrophil gelatinase-associated lipocalin, Interleukin-18, Kidney injury molecule-1, and Liver fatty acid–binding protein. In conclusion, we suggest the need for further meta-analyses with the availability of additional studies.

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Authors and Affiliations

  1. Pediatric Cardiac Center of the Messejana Hospital Dr. Carlos Alberto Studart Gomes, Fortaleza, CE, Brazil

    Candice Torres de Melo Bezerra Cavalcante, Klebia Magalhães Pereira Castello Branco, Isabel Cristina Leite Maia, Ronald Guedes Pompeu, Andrea Consuelo de Oliveira Telles & Anna Karina Martins Brito

  2. Department of Pediatrics, Fortaleza University (UNIFOR), Av. Washington Soares, 1321 - Edson Queiroz, CEP, Fortaleza, CE, 60811-905, Brazil

    Candice Torres de Melo Bezerra Cavalcante

  3. Department of Obstetrics and Gynecology, Fortaleza University (UNIFOR), Av. Washington Soares, 1321 - Edson Queiroz, CEP, Fortaleza, CE, 60811-905, Brazil

    Marcelo Borges Cavalcante

  4. The Heart Center, Seattle Children’s Hospital, University of Washington, Seattle, WA, USA

    Titus Chan

  5. Medical Sciences Postgraduate Program, Fortaleza University (UNIFOR), Av. Washington Soares, 1321 - Edson Queiroz, CEP, Fortaleza, CE, 60811-905, Brazil

    Marcelo Borges Cavalcante & Alexandre Braga Libório

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  1. Candice Torres de Melo Bezerra Cavalcante
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  2. Marcelo Borges Cavalcante
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  3. Klebia Magalhães Pereira Castello Branco
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  5. Isabel Cristina Leite Maia
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  9. Alexandre Braga Libório
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Contributions

A. Cavalcante—global concept of the study, data collection, and critical review of the manuscript. B. Cavalcante—global concept of the study, manuscript writing, interpretation and discussion of data, and critical review of the manuscript. C. Branco—manuscript writing, interpretation and discussion of data. D. Chang—interpretation and discussion of data and critical review of the manuscript. E. Libório—data collection and interpretation and critical review of the manuscript. F. Maia; Pompeu; Brito and Telles—critical review of the manuscript.

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Correspondence to Candice Torres de Melo Bezerra Cavalcante.

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The study was approved by regional independent ethics committees and national regulatory health authorities and conducted in accordance with Good Clinical Practices and the Declaration of Helsinki.

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Cavalcante, C.T.d.M.B., Cavalcante, M.B., Castello Branco, K.M.P. et al. Biomarkers of acute kidney injury in pediatric cardiac surgery. Pediatr Nephrol 37, 61–78 (2022). https://doi.org/10.1007/s00467-021-05094-9

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