SpringerLink
Log in

Swept source optical coherence tomography analysis of choroidal thickness in macular telangiectasia type 2: a case-control study

  • Retinal Disorders
  • Published:
Graefe's Archive for Clinical and Experimental Ophthalmology Aims and scope Submit manuscript

Abstract

Purpose

There has been a recent interest in the association of macular telangiectasia (MacTel) type 2 with central serous choroidopathy and other pachychoroid disorders. This study was performed to assess the subfoveal choroidal thickness (SFCT) in patients with MacTel type 2 and compare it with healthy controls using swept source optical coherence tomography (SS-OCT).

Methods

It was a retrospective case-control study performed at a tertiary eye care center. The cases constituted patients with MacTel type 2 detected over the last 2 years (April 2016 to March 2018). The controls were healthy adults with no posterior segment pathology. The patients were evaluated with color fundus photography, SS-OCT (Triton, Topcon Inc., Oakland, New Jersey, USA) and fundus fluorescein angiography. The cases were staged based on Gass and Blodi classification. SFCT was compared between the two groups.

Results

Sixty-five eyes of 33 patients with MacTel were included. The controls consisted of 61 eyes of 33 healthy age-matched (p = 0.81) and sex-matched (p = 0.31) adults. The mean SFCT in cases (353.0 ± 91.2 μm) was higher than controls (289.2 ± 69.0 μm), and this difference was statistically significant (p = 0.0001). The mean SFCT was different in various stages: 346.6 ± 86.3 μm (stage 2), 334.6 ± 90.2 μm (stage 3), 374.6 ± 94.0 μm (stage 4), and 294.8 ± 68.8 μm (stage 5), though this was not statistically significant (p = 0.28).

Conclusions

The choroid in MacTel type 2 patients was significantly thickened as compared to controls. SFCT may vary as the structural changes worsen over time.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Subscribe and save

Springer+ Basic
EUR 32.99 /Month
  • Get 10 units per month
  • Download Article/Chapter or Ebook
  • 1 Unit = 1 Article or 1 Chapter
  • Cancel anytime
Subscribe now

Buy Now

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3
Fig. 4
Fig. 5
Fig. 6

Similar content being viewed by others

References

  1. Issa PC, Gillies MC, Chew EY et al (2013) Macular telangiectasia type 2. Prog Retin Eye Res 34:49. https://doi.org/10.1016/j.preteyeres.2012.11.002

    Article  CAS  Google Scholar 

  2. Gaudric A, Ducos de Lahitte G, Cohen SY et al (2006) Optical coherence tomography in group 2A idiopathic juxtafoveolar retinal telangiectasis. Arch Ophthalmol 124:1410–1419. https://doi.org/10.1001/archopht.124.10.1410

    Article  PubMed  Google Scholar 

  3. Sanchez JG, Garcia RA, Wu L et al (2007) Optical coherence tomography characteristics of group 2A idiopathic parafoveal telangiectasis. Retina (Philadelphia, PA) 27:1214–1220. https://doi.org/10.1097/IAE.0b013e318074bc4b

    Article  Google Scholar 

  4. Bringmann A, Pannicke T, Grosche J et al (2006) Müller cells in the healthy and diseased retina. Prog Retin Eye Res 25:397–424. https://doi.org/10.1016/j.preteyeres.2006.05.003

    Article  PubMed  CAS  Google Scholar 

  5. Powner MB, Gillies MC, Zhu M et al (2013) Loss of Müller’s cells and photoreceptors in macular telangiectasia type 2. Ophthalmology 120:2344–2352. https://doi.org/10.1016/j.ophtha.2013.04.013

    Article  PubMed  Google Scholar 

  6. Nickla DL, Wallman J (2010) The multifunctional choroid. Prog Retin Eye Res 29:144–168. https://doi.org/10.1016/j.preteyeres.2009.12.002

    Article  PubMed  Google Scholar 

  7. Linsenmeier RA, Padnick-Silver L (2000) Metabolic Dependence of Photoreceptors on the Choroid in the Normal and Detached Retina. Invest Ophthalmol Vis Sci 41:3117–3123

    PubMed  CAS  Google Scholar 

  8. Imamura Y, Fujiwara T, Margolis R, Spaide RF (2009) Enhanced depth imaging optical coherence tomography of the choroid in central serous chorioretinopathy. Retina (Philadelphia, PA) 29:1469–1473. https://doi.org/10.1097/IAE.0b013e3181be0a83

    Article  Google Scholar 

  9. Maruko I, Iida T, Sugano Y et al (2011) Subfoveal choroidal thickness in fellow eyes of patients with central serous chorioretinopathy. Retina (Philadelphia, PA) 31:1603–1608. https://doi.org/10.1097/IAE.0b013e31820f4b39

    Article  Google Scholar 

  10. Grenga PL, Fragiotta S, Cutini A et al (2016) Enhanced depth imaging optical coherence tomography in adult-onset foveomacular vitelliform dystrophy. Eur J Ophthalmol 26:145–151. https://doi.org/10.5301/ejo.5000687

    Article  PubMed  Google Scholar 

  11. Fujiwara T, Imamura Y, Margolis R et al (2009) Enhanced depth imaging optical coherence tomography of the choroid in highly myopic eyes. Am J Ophthalmol 148:445–450. https://doi.org/10.1016/j.ajo.2009.04.029

    Article  PubMed  Google Scholar 

  12. Mrejen S, Spaide RF (2014) The relationship between pseudodrusen and choroidal thickness. Retina (Philadelphia, PA) 34:1560–1566. https://doi.org/10.1097/IAE.0000000000000139

    Article  Google Scholar 

  13. Thomas NR, Roy R, Saurabh K, Das K (2017) A rare case of idiopathic parafoveal telangiectasia associated with central serous chorioretinopathy. Indian J Ophthalmol 65:516–517. https://doi.org/10.4103/ijo.IJO_167_17

    Article  PubMed  PubMed Central  Google Scholar 

  14. Matet A, Yzer S, Chew EY et al (2018) Concurrent idiopathic macular telangiectasia type 2 and central serous chorioretinopathy. Retina (Philadelphia, PA) 38(Suppl 1):S67–S78. https://doi.org/10.1097/IAE.0000000000001836

    Article  Google Scholar 

  15. Kumar V, Kumar P, Ravani R, Gupta P (2018) Macular telangiectasia type II with pachychoroid spectrum of macular disorders. Eur J Ophthalmol. https://doi.org/10.1177/1120672118769527

  16. Chhablani J, Kozak I, Babu Jonnadula G et al (2014) Choroidal thickness in macular telangiectasia type 2. Retina (Philadelphia, PA) 34:1819–1823. https://doi.org/10.1097/IAE.0000000000000180

    Article  Google Scholar 

  17. Nunes RP, Goldhardt R, De CAGF et al (2015) Spectral-domain optical coherence tomography measurements of choroidal thickness and outer retinal disruption in macular telangiectasia type 2. Ophthalmic Surg Lasers Imaging Retina 46:162–170. https://doi.org/10.3928/23258160-20150213-17

    Article  PubMed  Google Scholar 

  18. Adhi M, Liu JJ, Qavi AH et al (2014) Choroidal analysis in healthy eyes using swept-source optical coherence tomography compared to spectral domain optical coherence tomography. Am J Ophthalmol 157:1272–1281.e1. https://doi.org/10.1016/j.ajo.2014.02.034

    Article  PubMed  Google Scholar 

  19. Copete S, Flores-Moreno I, Montero JA et al (2014) Direct comparison of spectral-domain and swept-source OCT in the measurement of choroidal thickness in normal eyes. Br J Ophthalmol 98:334–338. https://doi.org/10.1136/bjophthalmol-2013-303904

    Article  PubMed  Google Scholar 

  20. Tan CSH, Ngo WK, Cheong KX (2015) Comparison of choroidal thicknesses using swept source and spectral domain optical coherence tomography in diseased and normal eyes. Br J Ophthalmol 99:354–358. https://doi.org/10.1136/bjophthalmol-2014-305331

    Article  PubMed  Google Scholar 

  21. Gass JD, Blodi BA (1993) Idiopathic juxtafoveolar retinal telangiectasis. Update of classification and follow-up study. Ophthalmology 100:1536–1546

    Article  PubMed  CAS  Google Scholar 

  22. Chhablani J, Wong IY, Kozak I (2014) C6oroidal imaging: a review. Saudi J Ophthalmol 28:123–128. https://doi.org/10.1016/j.sjopt.2014.03.004

    Article  PubMed  PubMed Central  Google Scholar 

  23. Chhablani J, Rao PS, Venkata A et al (2014) Choroidal thickness profile in healthy Indian subjects. Indian J Ophthalmol 62:1060. https://doi.org/10.4103/0301-4738.146711

    Article  PubMed  PubMed Central  Google Scholar 

  24. Zafar S, Siddiqui MR, Shahzad R (2016) Comparison of choroidal thickness measurements between spectral-domain OCT and swept-source OCT in normal and diseased eyes. Clin Ophthalmol 10:2271–2276. https://doi.org/10.2147/OPTH.S117022

    Article  PubMed  PubMed Central  Google Scholar 

  25. Matsuo Y, Sakamoto T, Yamashita T et al (2013) Comparisons of choroidal thickness of normal eyes obtained by two different spectral-domain OCT instruments and one swept-source OCT instrument. Invest Ophthalmol Vis Sci 54:7630–7636. https://doi.org/10.1167/iovs.13-13135

    Article  PubMed  Google Scholar 

  26. Spaide RF, Koizumi H, Pozzoni MC, Pozonni MC (2008) Enhanced depth imaging spectral-domain optical coherence tomography. Am J Ophthalmol 146:496–500. https://doi.org/10.1016/j.ajo.2008.05.032

    Article  PubMed  Google Scholar 

  27. Choma MA, Hsu K, Izatt JA (2005) Swept source optical coherence tomography using an all-fiber 1300-nm ring laser source. J Biomed Opt 10:44009. https://doi.org/10.1117/1.1961474

    Article  PubMed  Google Scholar 

  28. Adhi M, Duker JS (2013) Optical coherence tomography—current and future applications. Curr Opin Ophthalmol 24:213–221. https://doi.org/10.1097/ICU.0b013e32835f8bf8

    Article  PubMed  PubMed Central  Google Scholar 

  29. Michalewski J, Michalewska Z, Nawrocka Z et al (2014) Correlation of choroidal thickness and volume measurements with axial length and age using swept source optical coherence tomography and optical low-coherence reflectometry. Biomed Res Int. https://doi.org/10.1155/2014/639160

  30. Atmani K, Querques G, Zourdani A et al (2013) Unusual presentations of type 2 idiopathic macular telangiectasia. Ophthalmologica 230:126–130. https://doi.org/10.1159/000354111

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Dr Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, India

    Vinod Kumar, Devesh Kumawat & Pradeep Kumar

Authors
  1. Vinod Kumar
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Devesh Kumawat
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Pradeep Kumar
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Devesh Kumawat.

Ethics declarations

Conflict of interest

The authors declare that they have no conflict of interest.

Ethical approval

For this type of study, formal consent is not required. This article does not contain any studies with animals performed by any of the authors.

Informed consent

Informed consent was obtained from all individual participants included in the study.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Kumar, V., Kumawat, D. & Kumar, P. Swept source optical coherence tomography analysis of choroidal thickness in macular telangiectasia type 2: a case-control study. Graefes Arch Clin Exp Ophthalmol 257, 567–573 (2019). https://doi.org/10.1007/s00417-018-04215-9

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00417-018-04215-9

Keywords

Search

Navigation