SpringerLink
Log in

The use of optical coherence tomography angiography in pachychoroid spectrum diseases: a concurrent comparison with dye angiography

  • Retinal Disorders
  • Published:
Graefe's Archive for Clinical and Experimental Ophthalmology Aims and scope Submit manuscript

Abstract

Purpose

The study objective was to compare dye angiography and optical coherence tomography angiography (OCTA) in detecting choroidal neovascuarization (CNV) in patients presenting with pachychoroid features and flat irregular pigment epithelial detachment (PED).

Methods

Nineteen eyes of 17 patients, presenting with flat PED and pachychoroid features, and without age-related macular degeneration or any other degenerative change, were analyzed. Fuorescein angiography (FA)/Indocyanine green angiography (ICGA) and OCTA were performed during the same visit. Subfoveal choroidal thickness was measured by enhanced depth imaging using spectral domain optical coherence tomography.

Results

The mean age of the patients was 59.1 years. Mean subfoveal choroidal thickness was 388 μm. FA revealed non-patognomic features including RPE alterations, window defects, leaking points and leakage from an undetermined source. ICGA revealed choroidal vascular plaque in eight eyes (42%) and suspicious plaque in five eyes (26%). Nonneovascular features, such as hyperpermeability or dilated choroidal vessels, were observed in six eyes (32%). OCTA showed choroidal neovascularization in 14 (74%). For all of the eyes, which ICGA was positive for presence of CNV, OCTA also showed CNV, and in one case it also revealed polypoidal characteristics of the neovascular network. OCTA was also able to detect CNV in all of the eyes with suspicious plaque, and in one eye without CNV appearance using ICGA.

Conclusions

OCTA demonstrated greater sensitivity in detecting type 1 CNV than conventional dye angiography in cases with pachychoroid spectrum disease.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Subscribe and save

Springer+ Basic
EUR 32.99 /Month
  • Get 10 units per month
  • Download Article/Chapter or Ebook
  • 1 Unit = 1 Article or 1 Chapter
  • Cancel anytime
Subscribe now

Buy Now

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3

Similar content being viewed by others

References

  1. Dansingani KK, Balaratnasingam C, Naysan J, Freund KB (2016) En face imaging of pachychoroid spectrum disorders with swept-source optical coherence tomography. Retina 36:499–516. https://doi.org/10.1097/IAE.0000000000000742

    Article  PubMed  Google Scholar 

  2. Gallego-Pinazo R, Dolz-Marco R, Gomez-Ulla F, Mrejen S, Freund KB (2014) Pachychoroid diseases of the macula. Med Hypothesis Discov Innov Ophthalmol 3:111–115

    PubMed  PubMed Central  Google Scholar 

  3. Warrow DJ, Hoang QV, Freund KB (2013) Pachychoroid pigment epitheliopathy. Retina 33:1659–1672. https://doi.org/10.1097/IAE.0b013e3182953df4

    Article  PubMed  Google Scholar 

  4. Lehmann M, Bousquet E, Beydoun T, Behar-Cohen F (2015) Pachychoroid: an inherited condition? Retina 35:10–16. https://doi.org/10.1097/IAE.0000000000000287

    Article  PubMed  Google Scholar 

  5. Pang CE, Freund KB (2015) Pachychoroid neovasculopathy. Retina 35:1–9. https://doi.org/10.1097/IAE.0000000000000331

    Article  CAS  PubMed  Google Scholar 

  6. Song IS, Shin YU, Lee BR (2012) Time-periodic characteristics in the morphology of idiopathic central serous chorioretinopathy evaluated by volume scan using spectral-domain optical coherence tomography. Am J Ophthalmol 154(366–375):e364. https://doi.org/10.1016/j.ajo.2012.02.031

    Google Scholar 

  7. Bousquet E, Bonnin S, Mrejen S, Krivosic V, Tadayoni R, Gaudric A (2017) Optical coherence tomography angiography of flat irregular pigment epithelium detachment in chronic central serous Chorioretinopathy. Retina. https://doi.org/10.1097/IAE.0000000000001580

  8. Bonini Filho MA, de Carlo TE, Ferrara D, Adhi M, Baumal CR, Witkin AJ, Reichel E, Duker JS, Waheed NK (2015) Association of Choroidal Neovascularization and Central Serous Chorioretinopathy with Optical Coherence Tomography Angiography. JAMA Ophthalmol 133:899–906. https://doi.org/10.1001/jamaophthalmol.2015.1320

    Article  PubMed  Google Scholar 

  9. Quaranta-El Maftouhi M, El Maftouhi A, Eandi CM (2015) Chronic central serous chorioretinopathy imaged by optical coherence tomographic angiography. Am J Ophthalmol 160(581–587):e581. https://doi.org/10.1016/j.ajo.2015.06.016

    Article  Google Scholar 

  10. Weng S, Mao L, Yu S, Gong Y, Cheng L, Chen X (2016) Detection of Choroidal neovascularization in central serous Chorioretinopathy using optical coherence Tomographic angiography. Ophthalmologica 236:114–121. https://doi.org/10.1159/000448630

    Article  PubMed  Google Scholar 

  11. Dansingani KK, Balaratnasingam C, Klufas MA, Sarraf D, Freund KB (2015) Optical coherence tomography angiography of shallow irregular pigment epithelial detachments in pachychoroid spectrum disease. Am J Ophthalmol 160(1243–1254):e1242. https://doi.org/10.1016/j.ajo.2015.08.028

    Google Scholar 

  12. Azar G, Wolff B, Mauget-Faysse M, Rispoli M, Savastano MC, Lumbroso B (2016) Pachychoroid neovasculopathy: aspect on optical coherence tomography angiography. Acta Ophthalmol. https://doi.org/10.1111/aos.13221

  13. Costanzo E, Cohen SY, Miere A, Querques G, Capuano V, Semoun O, El Ameen A, Oubraham H, Souied EH (2015) Optical coherence tomography angiography in central serous Chorioretinopathy. J Ophthalmol 2015:134783. https://doi.org/10.1155/2015/134783

    PubMed  PubMed Central  Google Scholar 

  14. de Carlo TE, Rosenblatt A, Goldstein M, Baumal CR, Loewenstein A, Duker JS (2016) Vascularization of irregular retinal pigment epithelial detachments in chronic central serous chorioretinopathy evaluated with OCT angiography. Ophthalmic Surg Lasers Imaging Retina 47:128–133. https://doi.org/10.3928/23258160-20160126-05

    Article  PubMed  Google Scholar 

  15. Hage R, Mrejen S, Krivosic V, Quentel G, Tadayoni R, Gaudric A (2015) Flat irregular retinal pigment epithelium detachments in chronic central serous chorioretinopathy and choroidal neovascularization. Am J Ophthalmol 159(890–903):e893. https://doi.org/10.1016/j.ajo.2015.02.002

    Google Scholar 

  16. Fung AT, Yannuzzi LA, Freund KB (2012) Type 1 (sub-retinal pigment epithelial) neovascularization in central serous chorioretinopathy masquerading as neovascular age-related macular degeneration. Retina 32:1829–1837. https://doi.org/10.1097/IAE.0b013e3182680a66

    Article  PubMed  Google Scholar 

  17. Miyake M, Ooto S, Yamashiro K, Takahashi A, Yoshikawa M, Akagi-Kurashige Y, Ueda-Arakawa N, Oishi A, Nakanishi H, Tamura H, Tsujikawa A, Yoshimura N (2015) Pachychoroid neovasculopathy and age-related macular degeneration. Sci Rep 5:16204. https://doi.org/10.1038/srep16204

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  18. Malihi M, Jia Y, Gao SS, Flaxel C, Lauer AK, Hwang T, Wilson DJ, Huang D, Bailey ST (2017) Optical coherence tomographic angiography of choroidal neovascularization ill-defined with fluorescein angiography. Br J Ophthalmol 101:45–50. https://doi.org/10.1136/bjophthalmol-2016-309094

    Article  PubMed  Google Scholar 

  19. Hata M, Yamashiro K, Ooto S, Oishi A, Tamura H, Miyata M, Ueda-Arakawa N, Takahashi A, Tsujikawa A, Yoshimura N (2017) Intraocular vascular endothelial growth factor levels in pachychoroid neovasculopathy and neovascular age-related macular degeneration. Invest Ophthalmol Vis Sci 58:292–298. https://doi.org/10.1167/iovs.16-20967

    Article  PubMed  Google Scholar 

  20. Koh A, Lee WK, Chen LJ, Chen SJ, Hashad Y, Kim H, Lai TY, Pilz S, Ruamviboonsuk P, Tokaji E, Weisberger A, Lim TH (2012) EVEREST study: efficacy and safety of verteporfin photodynamic therapy in combination with ranibizumab or alone versus ranibizumab monotherapy in patients with symptomatic macular polypoidal choroidal vasculopathy. Retina 32:1453–1464. https://doi.org/10.1097/IAE.0b013e31824f91e8

    Article  CAS  PubMed  Google Scholar 

Download references

Funding

No funding was received for this research.

Author information

Authors and Affiliations

  1. Department of Ophthalmology, Ankara University Faculty of Medicine, Vehbi Koç Göz Hastanesi, Mamak Caddesi, Dikimevi, Ankara, Turkey

    Sibel Demirel, Özge Yanık, Hilal Nalcı, Figen Batıoğlu & Emin Özmert

Authors
  1. Sibel Demirel
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Özge Yanık
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Hilal Nalcı
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Figen Batıoğlu
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Emin Özmert
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Sibel Demirel.

Ethics declarations

Conflict of interest

All authors certify that they have no affiliations with or involvement in any organization or entity with any financial interest, or non-financial interest in the subject matter or materials discussed in this manuscript.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards.

Informed consent

Informed consent was obtained from all individual participants included in the study.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Demirel, S., Yanık, Ö., Nalcı, H. et al. The use of optical coherence tomography angiography in pachychoroid spectrum diseases: a concurrent comparison with dye angiography. Graefes Arch Clin Exp Ophthalmol 255, 2317–2324 (2017). https://doi.org/10.1007/s00417-017-3793-8

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00417-017-3793-8

Keywords

Search

Navigation