Abstract
Background
Enhanced recovery after surgery (ERAS) is a clinical pathway that optimizes perioperative management based on evidence-based medicine. ERAS has been gradually introduced to pediatric surgery in recent years. However, there are limited reports on its overall implementation. We aimed to determine the implementation of ERAS in patients who received pediatric surgery in mainland China.
Methods
We designed a questionnaire involving 17 key ERAS elements and sent the questionnaire to 66 chiefs of pediatric surgery distributed throughout 31 provinces in mainland China to obtain a baseline assessment of the assimilation of ERAS protocols in the care of congenital biliary dilatation (CBD).
Results
A total of 66 questionnaires were collected. The range of elements implemented at participating centers was 4–16, with a mean of 10.23. The least commonly practiced elements were administration of non-opioid preoperative analgesia (6 centers, 9.09%), prevention of postoperative nausea and vomiting [PONV] (9 centers, 13.64%), and postoperative pain management (26 centers, 39.39%).
Conclusions
The implementation of elements differed from center to center. Measures relying primarily on anesthesiologists had lower execution. The adherence to ERAS elements was often inhibited by a lack of institutional support, poor knowledge of ERAS protocols, and difficulties in coordinating multidisciplinary care, as well intransigence in changing surgical practices out of fear of liability for poor outcomes.
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Data availability
The original data analysed during this current study are available from the corresponding author Weibing Tang (twbcn@163.com) on reasonable request.
Abbreviations
- CBD:
-
Congenital biliary dilatation
- CCC:
-
Congenital choledochal cyst
- ERAS:
-
Enhanced recovery after surgery
- LOS:
-
Length of stay
- NSQIP:
-
National Surgical Quality Improvement Program
- PONV:
-
Postoperative nausea and vomiting
References
Kehlet H, Dahl JB (2003) Anaesthesia, surgery, and challenges in postoperative recovery. The Lancet (Br Ed) 362:1921–1928. https://doi.org/10.1016/S0140-6736(03)14966-5
Nygren J, Thacker J, Carli F, Fearon KC, Norderval S, Lobo DN, Ljungqvist O, Soop M, Ramirez J (2013) Guidelines for perioperative care in elective rectal/pelvic surgery: enhanced recovery after surgery (ERAS((R))) society recommendations. World J Surg 37:285–305. https://doi.org/10.1007/s00268-012-1787-6
Gustafsson UO, Scott MJ, Hubner M, Nygren J, Demartines N, Francis N, Rockall TA, Young-Fadok TM, Hill AG, Soop M, de Boer HD, Urman RD, Chang GJ, Fichera A, Kessler H, Grass F, Whang EE, Fawcett WJ, Carli F, Lobo DN, Rollins KE, Balfour A, Baldini G, Riedel B, Ljungqvist O (2019) Guidelines for perioperative care in elective colorectal surgery: enhanced recovery after surgery (ERAS®) society recommendations: 2018. World J Surg 43:659–695. https://doi.org/10.1007/s00268-018-4844-y
Gustafsson UO, Scott MJ, Schwenk W, Demartines N, Roulin D, Francis N, Mcnaught CE, Macfie J, Liberman AS, Soop M, Hill A, Kennedy RH, Lobo DN, Fearon K, Ljungqvist O (2013) Guidelines for perioperative care in elective colonic surgery: enhanced recovery after surgery (ERAS((R))) society recommendations. World J Surg 37:259–284. https://doi.org/10.1007/s00268-012-1772-0
Lassen K, Coolsen MM, Slim K, Carli F, de Aguilar-Nascimento JE, Schafer M, Parks RW, Fearon KC, Lobo DN, Demartines N, Braga M, Ljungqvist O, Dejong CH (2013) Guidelines for perioperative care for pancreaticoduodenectomy: enhanced recovery after surgery (ERAS(R)) society recommendations. World J Surg 37:240–258. https://doi.org/10.1007/s00268-012-1771-1
Tang J, Liu X, Ma T, Lv X, Jiang W, Zhang J, Changgui L, Chen H, Li W, Li H, **e H, Chunxia D, Geng Q, Feng J, Tang W (2020) Application of enhanced recovery after surgery during the perioperative period in infants with Hirschsprung’s disease - a multi-center randomized clinical trial. Clin Nutr (Edinb, Scotl) 39:2062–2069. https://doi.org/10.1016/j.clnu.2019.10.001
Gao R, Yang H, Li Y, Meng L, Li Y, Sun B, Zhang G, Yue M, Guo F (2019) Enhanced recovery after surgery in pediatric gastrointestinal surgery. J Int Med Res 47:4815–4826. https://doi.org/10.1177/0300060519865350
Vrecenak JD, Mattei P (2014) Fast-track management is safe and effective after bowel resection in children with Crohn’s disease. J Pediatr Surg 49(99–102):102–103. https://doi.org/10.1016/j.jpedsurg.2013.09.038
Edney JC, Lam H, Raval MV, Heiss KF, Austin TM (2019) Implementation of an enhanced recovery program in pediatric laparoscopic colorectal patients does not worsen analgesia despite reduced perioperative opioids: a retrospective, matched, non-inferiority study. Reg Anesth Pain M 44:123–129. https://doi.org/10.1136/rapm-2018-000017
Brindle ME, Heiss K, Scott MJ, Herndon CA, Ljungqvist O, Koyle MA (2019) Embracing change: the era for pediatric ERAS is here. Pediatr Surg Int 35:631–634. https://doi.org/10.1007/s00383-019-04476-3
Rafeeqi T, Pearson EG (2021) Enhanced recovery after surgery in children. Transl Gastroenterol Hepatol 6:46. https://doi.org/10.21037/tgh-20-188
Salaün J, Ecoffey C, Orliaguet G (2021) Enhanced recovery in children: how could we go further? World J Pediatr Surg 4:e288. https://doi.org/10.1136/wjps-2021-000288
Leeds IL, Boss EF, George JA, Strockbine V, Wick EC, Jelin EB (2016) Preparing enhanced recovery after surgery for implementation in pediatric populations. J Pediatr Surg 51:2126–2129. https://doi.org/10.1016/j.jpedsurg.2016.08.029
Sastry AV, Abbadessa B, Wayne MG, Steele JG, Cooperman AM (2015) What is the incidence of biliary carcinoma in choledochal cysts, when do they develop, and how should it affect management? World J Surg 39:487–492. https://doi.org/10.1007/s00268-014-2831-5
Kamisawa T, Kaneko K, Itoi T, Ando H (2017) Pancreaticobiliary maljunction and congenital biliary dilatation. Lancet Gastroenterol Hepatol 2:610–618. https://doi.org/10.1016/S2468-1253(17)30002-X
Ishibashi H, Shimada M, Kamisawa T, Fujii H, Hamada Y, Kubota M, Urushihara N, Endo I, Nio M, Taguchi T, Ando H (2017) Japanese clinical practice guidelines for congenital biliary dilatation. J Hepatobiliary Pancreat Sci 24:1–16. https://doi.org/10.1002/jhbp.415
Hamada Y, Ando H, Kamisawa T, Itoi T, Urushihara N, Koshinaga T, Saito T, Fujii H, Morotomi Y (2016) Diagnostic criteria for congenital biliary dilatation 2015. J Hepatobiliary Pancreat Sci 23:342–346. https://doi.org/10.1002/jhbp.346
Jones RE, Zagory JA, Clark RA, Pandya SR (2021) A narrative review of the modern surgical management of pediatric choledochal cysts. Transl Gastroenterol Hepatol 6:37. https://doi.org/10.21037/tgh-20-235
Vacek J, Davis T, Many BT, Close S, Blake S, Hu Y, Holl JL, Johnson J, Strople J, Raval MV (2020) A baseline assessment of enhanced recovery protocol implementation at pediatric surgery practices performing inflammatory bowel disease operations. J Pediatr Surg 55:1996–2006. https://doi.org/10.1016/j.jpedsurg.2020.06.021
Pozzi G, Falcone A, Sabbatino F, Solej M, Nano M (2012) Fast track surgery in the north-west of Italy: influence on the orientation of surgical practice. Updates Surg 64:131–144. https://doi.org/10.1007/s13304-012-0154-3
Brindle ME, McDiarmid C, Short K, Miller K, MacRobie A, Lam JYK, Brockel M, Raval MV, Howlett A, Lee K-S, Offringa M, Wong K, de Beer D, Wester T, Skarsgard ED, Wales PW, Fecteau A, Haliburton B, Goobie SM, Nelson G (2020) Consensus guidelines for perioperative care in neonatal intestinal surgery: enhanced recovery after surgery (ERAS) society recommendations. World J Surg 44:2482–2492. https://doi.org/10.1007/s00268-020-05530-1
Gan TJ, Belani KG, Bergese S, Chung F, Diemunsch P, Habib AS, ** Z, Kovac AL, Meyer TA, Urman RD, Apfel CC, Ayad S, Beagley L, Candiotti K, Englesakis M, Hedrick TL, Kranke P, Lee S, Lipman D, Minkowitz HS, Morton J, Philip BK (2020) Fourth consensus guidelines for the management of postoperative nausea and vomiting. Anesth Analg 131:411–448. https://doi.org/10.1213/ANE.0000000000004833
Zhao H, Cai D, Gao Z, Chen Q, Zhu J, Huang J (2019) Application of enhanced recovery after surgery in the treatment of children with congenital choledochal cyst. J Zhejiang Univ (Med Sci) 48:474–480. https://doi.org/10.3785/j.issn.1008-9292.2019.10.02
Tan Y, Shen Y, Li L, Yu J (2020) Protocol for enhanced recovery after surgery with 3D laparoscopic excision for choledochal cysts can benefit the recovery process. Pediatr Surg Int 36:643–648. https://doi.org/10.1007/s00383-020-04644-w
White PF, Kehlet H, Neal JM, Schricker T, Carr DB, Carli F (2007) The role of the anesthesiologist in fast-track surgery: from multimodal analgesia to perioperative medical care. Anesth Analg 104:1380–1396. https://doi.org/10.1213/01.ane.0000263034.96885.e1
Foss NB, Christensen DS, Krasheninnikoff M, Kristensen BB, Kehlet H (2006) Post-operative rounds by anaesthesiologists after hip fracture surgery: a pilot study. Acta Anaesthesiol Scand 50:437–442. https://doi.org/10.1111/j.1399-6576.2005.00944.x
Matthews LS, Wootton SA, Davies SJ, Levett D (2021) Screening, assessment and management of perioperative malnutrition: a survey of UK practice. Perioper Med (Lond) 10:30. https://doi.org/10.1186/s13741-021-00196-2
Williams SB, Cumberbatch MGK, Kamat AM, Jubber I, Kerr PS, Mcgrath JS, Djaladat H, Collins JW, Packiam VT, Steinberg GD, Lee E, Kassouf W, Black PC, Cerantola Y, Catto JWF, Daneshmand S (2020) Reporting radical cystectomy outcomes following implementation of enhanced recovery after surgery protocols: a systematic review and individual patient data meta-analysis. Eur Urol 78:719–730. https://doi.org/10.1016/j.eururo.2020.06.039
Memtsoudis SG, Poeran J, Kehlet H (2019) Enhanced recovery after surgery in the United States: from evidence-based practice to uncertain science? JAMA 321:1049–1050. https://doi.org/10.1001/jama.2019.1070
Bhandare M, Thomas M, Joshi R, Agarwal V (2020) Complications after supramajor gastrointestinal surgery: role of enhanced recovery after surgery. Indian J Crit Care Med 24:S205–S210. https://doi.org/10.5005/jp-journals-10071-23615
Teng CY, Myers S, Kenkre TS, Doney L, Tsang WL, Subramaniam K, Esper SA, Holder-Murray J (2021) Targets for intervention? Preoperative predictors of postoperative ileus after colorectal surgery in an enhanced recovery protocol. J Gastrointest Surg 25:2065–2075. https://doi.org/10.1007/s11605-020-04876-0
Pickens RC, Cochran AR, Lyman WB, King L, Iannitti DA, Martinie JB, Baker EH, Ocuin LM, Riggs SB, Davis BR, Matthews BD, Vrochides D (2021) Impact of multidisciplinary audit of enhanced recovery after surgery (ERAS)® programs at a single institution. World J Surg 45:23–32. https://doi.org/10.1007/s00268-020-05765-y
D’ Andrea AP, Khetan P, Miller R, Sylla P, Divino CM (2020) Outcomes after bowel resection for inflammatory bowel disease in the era of surgical care bundles and enhanced recovery. J Gastrointest Surg 24:123–131. https://doi.org/10.1007/s11605-019-04362-2
Ivers N, Jamtvedt G, Flottorp S, Young JM, Odgaard-Jensen J, French SD, O’Brien MA, Johansen M, Grimshaw J, Oxman AD (2012) Audit and feedback: effects on professional practice and healthcare outcomes. Cochrane Database Syst Rev. https://doi.org/10.1002/14651858.CD000259.pub3
Heiss K (2020) Commentary regarding a baseline assessment of enhanced recovery protocol implementation at pediatric surgery practices performing inflammatory bowel disease surgeries. J Pediatr Surg 55:2007–2008. https://doi.org/10.1016/j.jpedsurg.2020.06.020
Pediatric Surgery Branch CMA, Pediatric Anesthesiology Group CSOA (2021) Expert consensus on perioperative management of children under the guidance of enhanced recovery after surgery. Chin J Pediatr Surg 42:1057–1065. https://doi.org/10.3760/cma.j.cn421158-20210822-00417
Acknowledgements
The authors thank all respondents who participated in this survey and professionals who offered help.
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WT: conceptualization, methodology, supervision; NX: software, formal analysis, investigation, data curation, writing—original draft, visualization; HX: visualization, writing—review and editing, project administration. All authors read and approved the final manuscript.
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Informed consent was obtained from all individual participants included in the study. The study was approved by the Ethics Committee of Nan**g Children's Hospital affiliated to Nan**g Medical University.
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**e, N., **e, H. & Tang, W. Baseline assessment of enhanced recovery after pediatric surgery in mainland China. Pediatr Surg Int 39, 32 (2023). https://doi.org/10.1007/s00383-022-05315-8
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DOI: https://doi.org/10.1007/s00383-022-05315-8