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Causal associations of immune cells with benign prostatic hyperplasia: insights from a Mendelian randomization study

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World Journal of Urology Aims and scope Submit manuscript

A Letter to the Editor to this article was published on 29 May 2024

Abstract

Background

Previous research has focused on the association between immune cells and the development of benign prostatic hyperplasia (BPH). Nevertheless, the causal relationships in this context remain uncertain.

Methods

This study employed a comprehensive and systematic two-sample Mendelian randomization (MR) analysis to determine the causal relationships between immunophenotypes and BPH. We examined the causal associations between 731 immunophenotypes and the risk of BPH by utilizing publicly available genetic data. Integrated sensitivity analyses were performed to validate the robustness, assess heterogeneity, and examine horizontal pleiotropy in the results.

Results

We discovered that 38 immunophenotypes have a causal effect on BPH. Subsequently, four of these immunophenotypes underwent verification using weighted median, weighted mode, and inverse variance weighted (IVW) algorithms, which included CD19 on CD24+ CD27+, CD19 on naive-mature B cell, HLA DR on CD14− CD16+ and HLA DR+ T cell%lymphocyte. Furthermore, BPH exhibited a significant association with three immunophenotypes: CD19 on IgD+ CD38dim (β = −0.152, 95% CI = 0.746–0.989, P = 0.034), CD19 on IgD+ (β = −0.167, 95% CI = 0.737–0.973, P = 0.019), and CD19 on naive-mature B cell (β = −0.166, 95% CI = 0.737–0.972, P = 0.018).

Conclusions

Our study provides valuable insights for future clinical investigations by establishing a significant association between immune cells and BPH.

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Data availability

All data and material are availability. The data used to support the findings of this study are available from the corresponding author upon request.

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Funding

This work was supported by National Natural Science Foundation of China (Grant No. 81870516).

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Author notes

  1. Tiewen Li, Yichen Zhang, and Zeng Zhou have contributed equally to this work and share the first authorship.

Authors and Affiliations

  1. Department of Urology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Wu** Road 85, Shanghai, 200080, China

    Tiewen Li, Yichen Zhang, Zeng Zhou, Yu Zhang, **aodong Song, Xuehao Zhou, Zhong Wan & Yuan Ruan

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  1. Tiewen Li
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  2. Yichen Zhang
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  3. Zeng Zhou
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  4. Yu Zhang
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  7. Zhong Wan
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Contributions

TL and YZ designed and completed original manuscript writing; ZZ, YZ and XS implemented data analysis and literature collection; XZ reviewed the manuscript; YR and ZW supervised and funded this work. All authors read and approved the final manuscript.

Corresponding authors

Correspondence to Zhong Wan or Yuan Ruan.

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Li, T., Zhang, Y., Zhou, Z. et al. Causal associations of immune cells with benign prostatic hyperplasia: insights from a Mendelian randomization study. World J Urol 42, 216 (2024). https://doi.org/10.1007/s00345-024-04913-6

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