Abstract
Carotenoids are pigments that may be used as colorants and antioxidants in food, pharmaceutical, and cosmetic industries. Since they also benefit human health, great efforts have been undertaken to search for natural sources of carotenoids, including microbial ones. The optimization of culture conditions to increase carotenoid yield is one of the strategies used to minimize the high cost of carotenoid production by microorganisms. Halophilic archaea are capable of producing carotenoids according to culture conditions. Their main carotenoid is bacterioruberin with 50 carbon atoms. In fact, the carotenoid has important biological functions since it acts as cell membrane reinforcement and it protects the microorganism against DNA damaging agents. Moreover, carotenoid extracts from halophilic archaea have shown high antioxidant capacity. Therefore, current review summarizes the effect of different culture conditions such as salt and carbon source concentrations in the medium, light incidence, and oxygen tension on carotenoid production by halophilic archaea and the strategies such as optimization methodology and two-stage cultivation already used to increase the carotenoid yield of these microorganisms.
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The authors thank the National Council for the Improvement of Higher Education (CAPES), a Brazilian governmental agency, and the Pharmaceutical Sciences Post-graduation Program, for the financial support.
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Calegari-Santos, R., Diogo, R.A., Fontana, J.D. et al. Carotenoid Production by Halophilic Archaea Under Different Culture Conditions. Curr Microbiol 72, 641–651 (2016). https://doi.org/10.1007/s00284-015-0974-8
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DOI: https://doi.org/10.1007/s00284-015-0974-8