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MCMV avoidance of recognition and control by NK cells

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Abstract

Natural killer (NK) cells play an important role in virus control during infection. Many viruses have developed mechanisms for subversion of NK cell responses. Murine cytomegalovirus (MCMV) is exceptionally successful in avoiding NK cell control. Here, we summarize the major MCMV evasion mechanisms targeting NK cell functions and their role in viral pathogenesis. The mechanisms by which NK cells regulate CD8+ T cell response, particularly with respect to the role of NK cell receptors recognizing viral antigens, are discussed. In addition, we discuss the role of NK cell receptors in generation and maintenance of memory NK cells. Final part of this review illustrates how the NK cell response and its viral regulation can be exploited in designing recombinant viral vectors able to induce robust and protective CD8+ T cell response.

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Acknowledgments

We apologize to our colleagues whose work was not cited due to space limitations. Stipan Jonjić is supported by the European Research Council (ERC) Advanced Grant (Grant number: 322693). This work has been supported in part by Croatian Science Foundation under the projects 1533 and 7132.

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  1. Center for Proteomics and Department of Histology and Embryology, Faculty of Medicine, University of Rijeka, B. Branchetta 20, 51000, Rijeka, Croatia

    Ilija Brizić, Tihana Lenac Roviš, Astrid Krmpotić & Stipan Jonjić

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  1. Ilija Brizić
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  2. Tihana Lenac Roviš
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  4. Stipan Jonjić
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Correspondence to Stipan Jonjić.

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This article is a contribution to the special issue on Immune Modulation, properties and models of CMV - Guest Editor: Ofer Mandelboim

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Brizić, I., Lenac Roviš, T., Krmpotić, A. et al. MCMV avoidance of recognition and control by NK cells. Semin Immunopathol 36, 641–650 (2014). https://doi.org/10.1007/s00281-014-0441-9

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