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Proteins, peptides, polysaccharides, and nucleotides with inhibitory activity on human immunodeficiency virus and its enzymes

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Abstract

Human immunodeficiency virus (HIV), the causative agent of acquired immune deficiency syndrome, has claimed innumerable lives in the past. Many biomolecules which suppress HIV replication and also other biomolecules that inhibit enzymes essential to HIV replication have been reported. Proteins including a variety of milk proteins, ribosome-inactivating proteins, ribonucleases, antifungal proteins, and trypsin inhibitors; peptides comprising cathelicidins, defensins, synthetic peptides, and others; polysaccharides and polysaccharopeptides; nucleosides, nucleotides, and ribozymes, demonstrated anti-HIV activity. In many cases, the mechanism of anti-HIV action has been elucidated. Strategies have been devised to augment the anti-HIV potency of these compounds.

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The authors declare that they have no competing interests.

Funding

This study was funded by HMRF grants (grant number 12110672 and 12131221).

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This article does not contain any studies with human participants or animals performed by any of the authors.

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Authors and Affiliations

  1. School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, New Territories, China

    Tzi Bun Ng, Randy Chi Fai Cheung, Jack Ho Wong & Wai Yee Chan

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  1. Tzi Bun Ng
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  2. Randy Chi Fai Cheung
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  3. Jack Ho Wong
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  4. Wai Yee Chan
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Correspondence to Tzi Bun Ng or Wai Yee Chan.

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Ng, T.B., Cheung, R.C.F., Wong, J.H. et al. Proteins, peptides, polysaccharides, and nucleotides with inhibitory activity on human immunodeficiency virus and its enzymes. Appl Microbiol Biotechnol 99, 10399–10414 (2015). https://doi.org/10.1007/s00253-015-6997-z

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  • DOI: https://doi.org/10.1007/s00253-015-6997-z

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