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Autophagy: a promising process for the treatment of acetaminophen-induced liver injury

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Abstract

Toxicity from drugs has become an important cause of acute liver failure. Acetaminophen, a commonly used analgesic, can cause severe acute liver injury that can worsen into acute liver failure. Autophagy, a protective cell programme, has been reported to have protective effects in a variety of diseases such as cancer, immune diseases, neurodegenerative diseases, and inflammatory diseases. In this review, we describe how an excess of acetaminophen causes liver injury step by step, from the formation of the initial protein adduct to the final hepatocyte necrosis, as well as the induction of autophagy and its beneficial effects on diseases. Emphasis is placed on the potential effect of autophagy on improving the damage of acetaminophen to hepatocytes. Finally, we are committed to providing insights into the treatment of acute liver failure through the mechanism of acetaminophen induced liver injury, the mechanism of autophagy, and the link between autophagy and liver injury.

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Acknowledgements

This work was financially supported by the Science and Technology Planning Project of Yunfu, Guangdong, China (no. 201702-9); Guangdong Provincial University Engineering Technology Research Center of Natural Products and Drugs, China (no. 2017GCZX002); and the Science and Technology Planning Project of Guangdong, China (no. 201806040009, 201804010349, 201804010329); Innovation Strong School Project of Guangdong Pharmaceutical University, China.

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  1. Guangdong Engineering Research Center of Natural Products and New Drugs, Guangdong Provincial University Engineering Technology Research Center of Natural Products and Drugs, Guangdong Pharmaceutical University, Guangzhou, China

    Qiuhua Tan, Yongjian Liu, **aoyi Deng, Jiajia Chen & Zhengquan Su

  2. Guangdong Metabolic Diseases Research Centre of Integrated Chinese and Western Medicine, Guangdong Pharmaceutical University, Guangzhou, China

    Qiuhua Tan, Yongjian Liu, **aoyi Deng, Jiajia Chen & Jiao Guo

  3. King-Prebiotics Biotechnology (TW) CO., Ltd., New Taipei City, Taiwan, ROC

    **-Ju Tsai & Pei-Hsuan Chen

  4. New Francisco (Yunfu City) Biotechnology CO. Ltd., Yunfu, China

    Manxiang Ye

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Tan, Q., Liu, Y., Deng, X. et al. Autophagy: a promising process for the treatment of acetaminophen-induced liver injury. Arch Toxicol 94, 2925–2938 (2020). https://doi.org/10.1007/s00204-020-02780-9

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