SpringerLink
Log in

Initiation of continuous renal replacement therapy versus intermittent hemodialysis in critically ill patients with severe acute kidney injury: a secondary analysis of STARRT-AKI trial

  • Original
  • Published:
Intensive Care Medicine Aims and scope Submit manuscript

Abstract

Background

There is controversy regarding the optimal renal-replacement therapy (RRT) modality for critically ill patients with acute kidney injury (AKI).

Methods

We conducted a secondary analysis of the STandard versus Accelerated Renal Replacement Therapy in Acute Kidney Injury (STARRT-AKI) trial to compare outcomes among patients who initiated RRT with either continuous renal replacement therapy (CRRT) or intermittent hemodialysis (IHD). We generated a propensity score for the likelihood of receiving CRRT and used inverse probability of treatment with overlap-weighting to address baseline inter-group differences. The primary outcome was a composite of death or RRT dependence at 90-days after randomization.

Results

We identified 1590 trial participants who initially received CRRT and 606 who initially received IHD. The composite outcome of death or RRT dependence at 90-days occurred in 823 (51.8%) patients who commenced CRRT and 329 (54.3%) patients who commenced IHD (unadjusted odds ratio (OR) 0.90; 95% confidence interval (CI) 0.75–1.09). After balancing baseline characteristics with overlap weighting, initial receipt of CRRT was associated with a lower risk of death or RRT dependence at 90-days compared with initial receipt of IHD (OR 0.81; 95% CI 0.66–0.99). This association was predominantly driven by a lower risk of RRT dependence at 90-days (OR 0.61; 95% CI 0.39–0.94).

Conclusions

In critically ill patients with severe AKI, initiation of CRRT, as compared to IHD, was associated with a significant reduction in the composite outcome of death or RRT dependence at 90-days.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Subscribe and save

Springer+ Basic
EUR 32.99 /Month
  • Get 10 units per month
  • Download Article/Chapter or Ebook
  • 1 Unit = 1 Article or 1 Chapter
  • Cancel anytime
Subscribe now

Buy Now

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2

Similar content being viewed by others

Availability of data and materials

The STARRT-AKI has a data sharing policy available at: https://www.ualberta.ca/critical-care/research/current-research/starrtaki/documents.html.

Abbreviations

AKI:

Acute kidney injury

CKD:

Chronic kidney disease

CRRT:

Continuous renal replacement therapy

DM:

Diabetes mellitus

GFR:

Glomerular filtration rate

ICU:

Intensive care unit

IHD:

Intermittent hemodialysis

IPTW:

Inverse probability of treatment weighting

KDIGO:

Kidney Disease: Improving Global Outcomes

RRT:

Renal-replacement therapy

SAPS:

Simplified Acute Physiology Score

SOFA:

Sequential Organ Failure Assessment

References

  1. Hoste EA, Bagshaw SM, Bellomo R, Cely CM, Colman R, Cruz DN, Edipidis K, Forni LG, Gomersall CD, Govil D, Honore PM, Joannes-Boyau O, Joannidis M, Korhonen AM, Lavrentieva A, Mehta RL, Palevsky P, Roessler E, Ronco C, Uchino S, Vazquez JA, Vidal Andrade E, Webb S, Kellum JA (2015) Epidemiology of acute kidney injury in critically ill patients: the multinational AKI-EPI study. Intensive Care Med 41(8):1411–1423

    Article  PubMed  Google Scholar 

  2. Nisula S, Kaukonen KM, Vaara ST, Korhonen AM, Poukkanen M, Karlsson S, Haapio M, Inkinen O, Parviainen I, Suojaranta-Ylinen R, Laurila JJ, Tenhunen J, Reinikainen M, Ala-Kokko T, Ruokonen E, Kuitunen A, Pettila V, Group FS (2013) Incidence, risk factors and 90-day mortality of patients with acute kidney injury in Finnish intensive care units: the FINNAKI study. Intensive Care Med 39(3):420–428

    Article  PubMed  Google Scholar 

  3. Ostermann M, Bagshaw SM, Lumlertgul N, Wald R (2022) Indications for and Timing of Initiation of KRT. Clin J Am Soc Nephrol. https://doi.org/10.2215/CJN.05450522

    Article  PubMed  Google Scholar 

  4. Wald R, Beaubien-Souligny W, Chanchlani R, Clark EG, Neyra JA, Ostermann M, Silver SA, Vaara S, Zarbock A, Bagshaw SM (2022) Delivering optimal renal replacement therapy to critically ill patients with acute kidney injury. Intensive Care Med 48(10):1368–1381

    Article  PubMed  Google Scholar 

  5. Gaudry S, Palevsky PM, Dreyfuss D (2022) Extracorporeal kidney-replacement therapy for acute kidney injury. N Engl J Med 386(10):964–975

    Article  CAS  PubMed  Google Scholar 

  6. Tolwani A (2012) Continuous renal-replacement therapy for acute kidney injury. N Engl J Med 367(26):2505–2514

    Article  CAS  PubMed  Google Scholar 

  7. Ostermann M, Bellomo R, Burdmann EA, Doi K, Endre ZH, Goldstein SL, Kane-Gill SL, Liu KD, Prowle JR, Shaw AD, Srisawat N, Cheung M, Jadoul M, Winkelmayer WC, Kellum JA, Conference P (2020) Controversies in acute kidney injury: conclusions from a Kidney Disease: improving Global Outcomes (KDIGO) Conference. Kidney Int 98(2):294–309

    Article  PubMed  PubMed Central  Google Scholar 

  8. Group KDIGOAKIGDW (2012) KDIGO clinical practice guidelines for acute kidney injury. Kidney Int 2(1):1–141

    Google Scholar 

  9. Bagshaw SM, Berthiaume LR, Delaney A, Bellomo R (2008) Continuous versus intermittent renal replacement therapy for critically ill patients with acute kidney injury: a meta-analysis. Crit Care Med 36(2):610–617

    Article  PubMed  Google Scholar 

  10. Nash DM, Przech S, Wald R, O’Reilly D (2017) Systematic review and meta-analysis of renal replacement therapy modalities for acute kidney injury in the intensive care unit. J Crit Care 41:138–144

    Article  PubMed  Google Scholar 

  11. Ye Z, Wang Y, Ge L, Guyatt GH, Collister D, Alhazzani W, Bagshaw SM, Belley-Cote EP, Fang F, Hou L, Kolb P, Lamontagne F, Oczkowski S, Pyne L, Rabbat C, Scaum M, Najafabadi BT, Tangamornsuksan W, Wald R, Wang Q, Walsh M, Yao L, Zeng L, Algarni AM, Couban RJ, Alexander PE, Rochwerg B (2021) Comparing renal replacement therapy modalities in critically ill patients with acute kidney injury: a systematic review and network meta-analysis. Crit Care Explor 3(5):e0399

    Article  PubMed  PubMed Central  Google Scholar 

  12. Schneider AG, Bellomo R, Bagshaw SM, Glassford NJ, Lo S, Jun M, Cass A, Gallagher M (2013) Choice of renal replacement therapy modality and dialysis dependence after acute kidney injury: a systematic review and meta-analysis. Intensive Care Med 39(6):987–997

    Article  CAS  PubMed  Google Scholar 

  13. Mehta RL, McDonald B, Gabbai FB, Pahl M, Pascual MT, Farkas A, Kaplan RM, Collaborative Group for Treatment of ARFitICU (2001) A randomized clinical trial of continuous versus intermittent dialysis for acute renal failure. Kidney Int 60(3):1154–1163

    Article  CAS  PubMed  Google Scholar 

  14. Uehlinger DE, Jakob SM, Ferrari P, Eichelberger M, Huynh-Do U, Marti HP, Mohaupt MG, Vogt B, Rothen HU, Regli B, Takala J, Frey FJ (2005) Comparison of continuous and intermittent renal replacement therapy for acute renal failure. Nephrol Dial Transplant 20(8):1630–1637

    Article  PubMed  Google Scholar 

  15. Vinsonneau C, Camus C, Combes A, Costa de Beauregard MA, Klouche K, Boulain T, Pallot JL, Chiche JD, Taupin P, Landais P, Dhainaut JF, Hemodiafe Study G (2006) Continuous venovenous haemodiafiltration versus intermittent haemodialysis for acute renal failure in patients with multiple-organ dysfunction syndrome: a multicentre randomised trial. Lancet 368(9533):379–385

    Article  PubMed  Google Scholar 

  16. Bell M, Swing GF, Schon S, Ekbom A, Martling CR (2007) Continuous renal replacement therapy is associated with less chronic renal failure than intermittent haemodialysis after acute renal failure. Intensive Care Med 33(5):773–780

    Article  PubMed  Google Scholar 

  17. Gaudry S, Grolleau F, Barbar S, Martin-Lefevre L, Pons B, Boulet E, Boyer A, Chevrel G, Montini F, Bohe J, Badie J, Rigaud JP, Vinsonneau C, Porcher R, Quenot JP, Dreyfuss D (2022) Continuous renal replacement therapy versus intermittent hemodialysis as first modality for renal replacement therapy in severe acute kidney injury: a secondary analysis of AKIKI and IDEAL-ICU studies. Crit Care 26(1):93

    Article  PubMed  PubMed Central  Google Scholar 

  18. Wald R, Shariff SZ, Adhikari NK, Bagshaw SM, Burns KE, Friedrich JO, Garg AX, Harel Z, Kitchlu A, Ray JG (2014) The association between renal replacement therapy modality and long-term outcomes among critically ill adults with acute kidney injury: a retrospective cohort study. Crit Care Med 42(4):868–877

    Article  CAS  PubMed  Google Scholar 

  19. Investigators STARRT-AKI, Bagshaw SM, Wald R, Adhikari NKJ, Bellomo R, da Costa BR, Dreyfuss D, Du B, Gallagher MP, Gaudry S, Hoste EA, Lamontagne F, Joannidis M, Landoni G, Liu KD, McAuley DF, McGuinness SP, Neyra JA, Nichol AD, Ostermann M, Palevsky PM, Pettila V, Quenot JP, Qiu H, Rochwerg B, Schneider AG, Smith OM, Thome F, Thorpe KE, Vaara S, Weir M, Wang AY, Young P, Zarbock A (2020) Timing of initiation of renal-replacement therapy in acute kidney injury. N Engl J Med 383(3):240–251

    Article  Google Scholar 

  20. Investigators STARRT-AKI (2019) Statistical analysis plan for the Standard versus Accelerated Initiation of Renal Replacement Therapy in Acute Kidney Injury (STARRT-AKI) trial. Crit Care Resusc 21(3):162–170

    Google Scholar 

  21. STARRT-AKI Investigators (2019) Standard versus accelerated initiation of renal replacement therapy in acute kidney injury: study protocol for a multi-national, multi-center, randomized controlled trial. Can J Kidney Health Dis 6:2054358119852937

    Google Scholar 

  22. Thomas LE, Li F, Pencina MJ (2020) Overlap weighting: a propensity score method that mimics attributes of a randomized clinical trial. JAMA 323(23):2417–2418

    Article  PubMed  Google Scholar 

  23. Sterne JA, White IR, Carlin JB, Spratt M, Royston P, Kenward MG, Wood AM, Carpenter JR (2009) Multiple imputation for missing data in epidemiological and clinical research: potential and pitfalls. BMJ 338:b2393

    Article  PubMed  PubMed Central  Google Scholar 

  24. Leyrat C, Seaman SR, White IR, Douglas I, Smeeth L, Kim J, Resche-Rigon M, Carpenter JR, Williamson EJ (2019) Propensity score analysis with partially observed covariates: How should multiple imputation be used? Stat Methods Med Res 28(1):3–19

    Article  PubMed  Google Scholar 

  25. Coffman DL, Zhou J, Cai X (2020) Comparison of methods for handling covariate missingness in propensity score estimation with a binary exposure. BMC Med Res Methodol 20(1):168

    Article  PubMed  PubMed Central  Google Scholar 

  26. da Costa BR, Gahl B, Juni P (2014) Tools and techniques–statistics: propensity score techniques. EuroIntervention 10(6):761–767

    Article  PubMed  Google Scholar 

  27. Ali MS, Prieto-Alhambra D, Lopes LC, Ramos D, Bispo N, Ichihara MY, Pescarini JM, Williamson E, Fiaccone RL, Barreto ML, Smeeth L (2019) Propensity score methods in health technology assessment: principles, extended applications, and recent advances. Front Pharmacol 10:973

    Article  PubMed  PubMed Central  Google Scholar 

  28. Li F, Thomas LE, Li F (2019) Addressing extreme propensity scores via the overlap weights. Am J Epidemiol 188(1):250–257

    PubMed  Google Scholar 

  29. Robins JM, Hernan MA, Brumback B (2000) Marginal structural models and causal inference in epidemiology. Epidemiology 11(5):550–560

    Article  CAS  PubMed  Google Scholar 

  30. Cole SR, Hernan MA (2008) Constructing inverse probability weights for marginal structural models. Am J Epidemiol 168(6):656–664

    Article  PubMed  PubMed Central  Google Scholar 

  31. Lins RL, Elseviers MM, Van der Niepen P, Hoste E, Malbrain ML, Damas P, Devriendt J, investigators S (2009) Intermittent versus continuous renal replacement therapy for acute kidney injury patients admitted to the intensive care unit: results of a randomized clinical trial. Nephrol Dial Transplant 24(2):512–518

    Article  PubMed  Google Scholar 

  32. Augustine JJ, Sandy D, Seifert TH, Paganini EP (2004) A randomized controlled trial comparing intermittent with continuous dialysis in patients with ARF. Am J Kidney Dis 44(6):1000–1007

    Article  PubMed  Google Scholar 

  33. Bonnassieux M, Duclos A, Schneider AG, Schmidt A, Benard S, Cancalon C, Joannes-Boyau O, Ichai C, Constantin JM, Lefrant JY, Kellum JA, Rimmele T, AzuRea G (2018) Renal replacement therapy modality in the ICU and renal recovery at hospital discharge. Crit Care Med 46(2):e102–e110

    Article  PubMed  Google Scholar 

  34. Naorungroj T, Neto AS, Wang A, Gallagher M, Bellomo R (2022) Renal outcomes according to renal replacement therapy modality and treatment protocol in the ATN and RENAL trials. Crit Care 26(1):269

    Article  PubMed  PubMed Central  Google Scholar 

  35. Berbece AN, Richardson RM (2006) Sustained low-efficiency dialysis in the ICU: cost, anticoagulation, and solute removal. Kidney Int 70(5):963–968

    Article  CAS  PubMed  Google Scholar 

  36. Schwenger V, Weigand MA, Hoffmann O, Dikow R, Kihm LP, Seckinger J, Miftari N, Schaier M, Hofer S, Haar C, Nawroth PP, Zeier M, Martin E, Morath C (2012) Sustained low efficiency dialysis using a single-pass batch system in acute kidney injury—a randomized interventional trial: the REnal Replacement Therapy Study in Intensive Care Unit PatiEnts. Crit Care 16(4):R140

    Article  PubMed  PubMed Central  Google Scholar 

  37. Klarenbach S, Manns B, Pannu N, Clement FM, Wiebe N, Tonelli M, Alberta Kidney Disease N (2009) Economic evaluation of continuous renal replacement therapy in acute renal failure. Int J Technol Assess Health Care 25(3):331–338

    Article  PubMed  Google Scholar 

  38. Manns B, Doig CJ, Lee H, Dean S, Tonelli M, Johnson D, Donaldson C (2003) Cost of acute renal failure requiring dialysis in the intensive care unit: clinical and resource implications of renal recovery. Crit Care Med 31(2):449–455

    Article  PubMed  Google Scholar 

  39. Srisawat N, Lawsin L, Uchino S, Bellomo R, Kellum JA, Kidney Investigators BEST (2010) Cost of acute renal replacement therapy in the intensive care unit: results from The Beginning and Ending Supportive Therapy for the Kidney (BEST Kidney) study. Crit Care 14(2):R46

    Article  PubMed  PubMed Central  Google Scholar 

  40. Ethgen O, Schneider AG, Bagshaw SM, Bellomo R, Kellum JA (2015) Economics of dialysis dependence following renal replacement therapy for critically ill acute kidney injury patients. Nephrol Dial Transplant 30(1):54–61

    Article  PubMed  Google Scholar 

  41. Schortgen F, Soubrier N, Delclaux C, Thuong M, Girou E, Brun-Buisson C, Lemaire F, Brochard L (2000) Hemodynamic tolerance of intermittent hemodialysis in critically ill patients: usefulness of practice guidelines. Am J Respir Crit Care Med 162(1):197–202

    Article  CAS  PubMed  Google Scholar 

  42. Evans L, Rhodes A, Alhazzani W, Antonelli M, Coopersmith CM, French C, Machado FR, McIntyre L, Ostermann M, Prescott HC, Schorr C, Simpson S, Wiersinga WJ, Alshamsi F, Angus DC, Arabi Y, Azevedo L, Beale R, Beilman G, Belley-Cote E, Burry L, Cecconi M, Centofanti J, Coz Yataco A, De Waele J, Dellinger RP, Doi K, Du B, Estenssoro E, Ferrer R, Gomersall C, Hodgson C, Moller MH, Iwashyna T, Jacob S, Kleinpell R, Klompas M, Koh Y, Kumar A, Kwizera A, Lobo S, Masur H, McGloughlin S, Mehta S, Mehta Y, Mer M, Nunnally M, Oczkowski S, Osborn T, Papathanassoglou E, Perner A, Puskarich M, Roberts J, Schweickert W, Seckel M, Sevransky J, Sprung CL, Welte T, Zimmerman J, Levy M (2021) Surviving sepsis campaign: international guidelines for management of sepsis and septic shock 2021. Intensive Care Med 47(11):1181–1247

    Article  PubMed  PubMed Central  Google Scholar 

  43. Wald R, Bagshaw SM, STARRT-AKI Investigators (2021) Integration of equipoise into eligibility criteria in the STARRT-AKI trial. Am J Respir Crit Care Med 204(2):234–237

    Article  PubMed  Google Scholar 

Download references

Acknowledgements

SMB is supported by a Canada Research Chair in Critical Care Outcomes and Systems Evaluation.

STARRT-AKI Investigators: Steering Committee: Sean M. Bagshaw (Co-Chair), Ron Wald (Co-Chair), Neill K. J. Adhikari, Rinaldo Bellomo, Didier Dreyfuss, Bin Du, Martin P. Gallagher, Stéphane Gaudry, Eric A. Hoste, François Lamontagne, Michael Joannidis, Kathleen D. Liu, Daniel F. McAuley, Shay P. McGuinness, Alistair D. Nichol, Marlies Ostermann, Paul M. Palevsky, Haibo Qiu, Ville Pettilä, Antoine G. Schneider, Orla M. Smith, Suvi T. Vaara, Matthew Weir. Australia: Austin Health: Rinaldo Bellomo, Glenn M. Eastwood, Leah Peck, Helen Young; Princess Alexandra Hospital: Peter Kruger, Gordon Laurie, Emma Saylor, Jason Meyer, Ellen Venz, Krista Wetzig; Western Health: Craig French, Forbes McGain, John Mulder, Gerard Fennessy, Sathyajith Koottayi, Samantha Bates, Miriam Towns, Rebecca Morgan, Anna Tippett; The Alfred Hospital: Andrew Udy, Chris Mason, Elisa Licari, Dashiell Gantner, Jason McClure, Alistair Nichol, Phoebe McCracken, Jasmin Board, Emma Martin, Shirley Vallance, Meredith Young, Chelsey Vladic, Steve McGloughlin; Royal Prince Alfred Hospital: David Gattas, Heidi Buhr, Jennifer Coles, Debra Hutch, James Wun; Nepean Hospital: Louise Cole, Christina Whitehead, Julie Lowrey, Kristy Masters, Rebecca Gresham; Sunshine Coast University Hospital: Victoria Campbell, David Gutierrez, Jane Brailsford, Loretta Forbes, Lauren Murray, Teena Maguire; Barwon Health: Martina NiChonghaile, Neil Orford, Allison Bone, Tania Elderkin, Tania Salerno; Bendigo Health: Tim Chimunda, Jason Fletcher, Emma Broadfield, Sanjay Porwal, Cameron Knott, Catherine Boschert, Julie Smith; Ballarat Health: Angus Richardson, Dianne Hill; Eastern Health: Graeme Duke, Peter Oziemski, Santiago Cegarra, Peter Chan, Deborah Welsh, Stephanie Hunter, Owen Roodenburg, John Dyett, Nicos Kokotsis, Max Moser, Yang, Laven Padayachee, Joseph Vetro, Himangsu Gangopadhyay, Melissa Kaufman; The Northern Hospital: Angaj Ghosh, Simone Said; Flinders Medical Centre: Alpesh Patel, Shailesh Bihari, Elisha Matheson, ** Lu, Yingtao Lian; Shandong Provincial Hospital: Chunting Wang, Jichen Zhang, Ruiqi Ding, Guoqing Qi, Qizhi Wang, Peng Wang, Zhaoli Meng, Man Chen, ** Zhao, Chenghuan Hu, **g Li, Fuxing Deng; Zhongda Hospital Southeast University: Haibo Qui, Yi Yang, Min Mo, Chun Pan, Changde Wu, Yingzi Huang, Lili Huang, Airan Liu. Finland: Helsinki University Hospital: Ville Pettilä, Suvi T. Vaara, Anna-Maija Korhonen, Sanna Törnblom, Sari Sutinen, Leena Pettilä, Jonna Heinonen, Eliria Lappi, Taria Suhonen; Tampere University Hospital: Sari Karlsson, Sanna Hoppu, Ville Jalkanen, Anne Kuitunen, Markus Levoranta, Jaakko Långsjö, Sanna Ristimäki, Kaisa Malila, Anna Wootten, Simo Varila; Turku University Hospital: Mikko J Järvisalo, Outi Inkinen, Satu Kentala, Keijo Leivo, Paivi Haltia. France: Hôpital Louis Mourier: Didier Dreyfuss, Jean-Damien Ricard, Jonathan Messika, Abirami Tiagarajah, Malo Emery, Aline Dechanet, Coralie Gernez, Damien Roux; Centre Hospitalier Départemental La Roche-Sur- Yon: Laurent Martin-Lefevre, Maud Fiancette, Isabelle Vinatier, Jean Claude Lacherade, Gwenhaël Colin, Christine Lebert, Marie-Ange Azais, Aihem Yehia, Caroline Pouplet, Matthieu Henry-Lagarrigue, Amélie Seguin, Laura Crosby; Medical Intensive Care Unit, Amiens University Hospital: Julien Maizel, Dimitri Titeca-Beauport; Hôpital Pitie-Salpetriere: Alain Combes, Ania Nieszkowska, Paul Masi, Alexandre Demoule, Julien Mayaux, Martin Dres, Elise Morawiec, Maxens Decalvele, Suela Demiri, Morgane Faure, Clémence Marios, Maxime Mallet, Marie Amélie Ordon, Laura Morizot, Marie Cantien, François Pousset; Hôpital Avicenne/Hôpital Jean Verdier: Stéphane Gaudry, Florent Poirson, Yves Cohen; Hospices Civils de Lyon, Hôpital Edouard Herriot, Service de Médecine Intensive – Réanimation: Laurent Argaud, Martin Cour, Laurent Bitker, Marie Simon, Romain Hernu, Thomas Baudry, Sylvie De La Salle; CH De Bourg-en-Bresse – Fleyriat: Adrien Robine, Nicholas Sedillot, Xavier Tchenio, Camille Bouisse, Sylvie Roux; CHRU de Nîmes: Saber Davide Barbar, Rémi Trusson; Rouen University Hospital: Fabienne Tamion, Steven Grangé, Dorothée Carpentier; CH Sud Francilien: Guillaume Chevrel, Luis Ensenyat-Martin, Sophie Marque; CHU Dijon: Jean-Pierre Quenot, Pascal Andreu, Auguste Dargent, Audrey Large; CH Le Mans - Réanimation Medico - Chirurgicale: Nicolas Chudeau, Mickael Landais, Benoit Derrien, Jean Christophe Callahan, Christophe Guitton, Charlène Le Moal, Alain Robert; CHU Nantes/Service d'Anesthésie - Réanimation chirurgicale HD PTMC: Karim Asehnoune, Raphaël Cinotti, Nicolas Grillot, Dominique Demeure; Germon et Gauthier Hospital – Béthune: Christophe Vinsonneau, Imen Rahmani, Mehdi Marzouk, Thibault Dekeyser, Caroline Sejourne, Mélanie Verlay, Fabienne Thevenin, Lucie Delecolle; Centre Hospitalier Lens: Didier Thevenin; Clermont Ferrand: Bertrand Souweine, Elisabeth Coupez, Mireille Adda; CH de Dieppe: Jean-Pierre Eraldi, Antoine Marchalot; Hôpital Henri Mondor: Nicolas De Prost, Armand Mekontso Dessap, Keyvan Razazi; Hôpital Civil: Ferhat Meziani, Julie Boisrame-Helms, Raphael Clere-Jehl, Xavier Delabranche, Christine Kummerlen, Hamid Merdji, Alexandra Monnier, Yannick Rabouel, Hassene Rahmani, Hayat Allam, Samir Chenaf, Vincenta Franja; CHU de Pointe à Pitre: Bertrand Pons, Michel Carles, Frédéric Martino, Régine Richard; André Mignot: Benjamin Zuber, Guillaume Lacave; CHU de Nantes: Karim Lakhal, Bertrand Rozec, Hoa Dang Van; Centre de Beaumont sur Oise: Éric Boulet; Centre Hospitalier René Dubos Pontoise: Fouad Fadel, Cedric Cleophax, Nicolas Dufour, Caroline Grant, Marie Thuong; Hotel Dieu – Service de Médicale: Jean Reignier, Emmanuel Canet, Laurent Nicolet; CHR Orleans: Thierry Boulain, Mai-Anh Nay, Dalila Benzekri, François Barbier, Anne Bretagnol, Toufik Kamel, Armelle Mathonnet, Grégoire Muller, Marie Skarzynski, Julie Rossi, Amandine Pradet, Sandra Dos Santos, Aurore Guery, Lucie Muller, Luis Felix; CH Lyon Sud – Pierre Benite: Julien Bohé, Guillaume Thiéry; Universite de Paris, Hopital Europeen Georges Pompidou: Nadia Aissaoui, Damien Vimpere, Morgane Commeureuc, Jean-Luc Diehl, Emmanuel Guerot. Germany: Klinikum Coburg: Orfeas Liangos, Monika Wittig; University Hospital Münster: Alexander Zarbock, Mira Küllmar, Thomas van Waegeningh, Nadine Rosenow. Ireland: St. Vincent's University Hospital: Alistair D. Nichol, Kathy Brickell, Peter Doran, Patrick T. Murray. Italy: IRCCS San Raffaele Scientific Institute: Giovanni Landoni, Rosalba Lembo, Alberto Zangrillo, Giacomo Monti, Margherita Tozzi, Matteo Marzaroli, Gaetano Lombardi; San Carlo Hospital: Gianluca Paternoster, Michelangelo Vitiello. New Zealand: Cardiovascular Surgical Intensive Care Unit, Auckland Hospital: Shay McGuinness, Rachael Parke, Magdalena Butler, Eileen Gilder, Keri-Anne Cowdrey, Samantha Wallace, Jane Hallion, Melissa Woolett, Philippa Neal, Karina Duffy, Stephanie Long; Department of Critical Care Medicine, Auckland Hospital: Colin McArthur, Catherine Simmonds, Yan Chen, Rachael McConnochie, Lynette Newby; Christchurch Hospital: David Knight, Seton Henderson, Jan Mehrtens, Stacey Morgan, Anna Morris, Kymbalee Vander Hayden, Tara Burke; Hawke's Bay Hospital: Matthew Bailey, Ross Freebairn, Lesley Chadwick, Penelope Park, Christine Rolls, Liz Thomas; Rotorua Hospital: Ulrike Buehner, Erin Williams; Taranaki Hospital: Jonathan Albrett, Simon Kirkham, Carolyn Jackson; Tauranga Hospital: Troy Browne, Jennifer Goodson, David Jackson, James Houghton, Owen Callender, Vicki Higson, Owen Keet, Clive Dominy; Wellington Hospital: Paul Young, Anna Hunt, Harriet Judd, Cassie Lawrence, Shaanti Olatunji, Yvonne Robertson, Charlotte Latimer-Bell, Deborah Hendry, Agnes Mckay-Vucago, Nina Beehre, Eden Lesona, Leanlove Navarra, Chelsea Robinson; Whangarei Hospital: Ryan Jang, Andrea Junge, Bridget Lambert. Switzerland: Centre Hospitalier Universitaire Vaudois: Antoine G. Schneider, Michel Thibault, Philippe Eckert, Sébastien Kissling, Erietta Polychronopoulos, Elettra Poli, Marco Altarelli, Madeleine Schnorf, Samia Abed Mallaird; Hôpitaux Universitaires de Genève: Claudia Heidegger, Aurelie Perret, Philippe Montillier, Frederic Sangla, Seigenthaller Neils, Aude De Watteville. United Kingdom: Barking, Havering and Redbridge University Hospitals NHS Trust: Mandeep-Kaur Phull, Aparna George, Nauman Hussain, Tatiana Pogreban; Barnsley Hospital NHS Foundation Trust: Steve Lobaz, Alison Daniels, Mishell Cunningham, Deborah Kerr, Alice Nicholson; Buckinghamshire Healthcare NHS Trust: Pradeep Shanmugasundaram, Judith Abrams, Katarina Manso, Geraldine Hambrook, Elizabeth McKerrow, Juvy Salva, Stephen Foulkes; Cardiff and Vale University Health Board: Matthew Wise, Matt Morgan, Jenny Brooks, Jade Cole, Tracy Michelle Davies, Helen Hill, Emma Thomas; Chelsea and Westminster Hospital NHS Foundation Trust: Marcela Vizcaychipi, Behrad Baharlo, Jaime Carungcong, Patricia Costa, Laura Martins; East Kent NHS Trust: Ritoo Kapoor, Tracy Hazelton, Angela Moon, Janine Musselwhite; Golden Jubilee National Hospital, NHS Scotland: Ben Shelley, Philip McCall; Guy's and St. Thomas’ NHS Foundation Trust: Marlies Ostermann, Gill Arbane, Aneta Bociek, Martina Marotti, Rosario Lim, Sara Campos, Neus Grau Novellas, Armando Cennamo, Andrew Slack, Duncan Wyncoll, Luigi Camporota, Simon Sparkes, Rosalinde Tilley; University Hairmyres Hospital, NHS Lanarkshire: Austin Rattray, Gayle Moreland, Jane Duffy, Elizabeth McGonigal; King's College Hospital NHS Foundation Trust: Philip Hopkins, Clare Finney, John Smith, Harriet Noble, Hayley Watson, Claire-Louise Harris, Emma Clarey, Eleanor Corcoran; Leeds Teaching Hospital NHS Foundation Trust: James Beck, Clare Howcroft, Nora Youngs, Elizabeth Wilby, Bethan Ogg; Lincoln County Hospital – United Lincolnshire Hospitals NHS Foundation Trust: Adam Wolverson, Sandra Lee, Susie Butler, Maryanne Okubanjo, Julia Hindle; Liverpool University Hospitals NHS Foundation Trust: Ingeborg Welters, Karen Williams, Emily Johnson, Julie Patrick-Heselton, David Shaw, Victoria Waugh; Milton Keynes University Hospital NHS Foundation Trust: Richard Stewart, Esther Mwaura, Lynn Wren, Louise Mew, Sara-Beth Sutherland, Jane Adderley; University Hospital Monklands, NHS Lanarkshire: Jim Ruddy, Margaret Harkins; NHS Grampian: Callum Kaye, Teresa Scott, Wendy Mitchell, Felicity Anderson, Fiona Willox; North Tees and Hartlepool Foundation NHS Trust: Vijay Jagannathan, Michele Clark, Sarah Purv; Nottingham University Hospital - Queen's Medical Centre: Andrew Sharman, Megan Meredith, Lucy Ryan, Louise Conner, Cecilia Peters, Dan Harvey; Queen Elizabeth Hospital - Lewisham and Greenwich NHS Trust: Ashraf Roshdy, Amy Collins; Queen Elizabeth University Hospital: Malcolm Sim, Steven Henderson; Royal Bournemouth & Christchurch Hospitals NHS Trust: Nigel Chee, Sally Pitts, Katie Bowman, Maria Dilawershah, Luke Vamplew, Elizabeth Howe; Royal Brompton and Harefield NHS Foundation Trust: Paula Rogers, Clara Hernandez, Clara Prendergast, Jane Benton, Alex Rosenberg; Royal Surrey County Hospital, NHS Foundation Trust: Lui G. Forni, Alice Grant, Paula Carvelli; Sheffield Teaching Hospitals NHS Foundation Trust: Ajay Raithatha, Sarah Bird, Max Richardson, Matthew Needham, Claire Hirst; St. George’s University Hospitals NHS Foundation Trust: Jonathan Ball, Susannah Leaver, Luisa Howlett, Carlos Castro Delgado, Sarah Farnell-Ward, Helen Farrah, Geraldine Gray, Gipsy Joseph, Francesca Robinson; St. Helen's and Knowsley Teaching Hospitals NHS Trust: Ascanio Tridente, Clare Harrop, Karen Shuker; University Hospital Ayr, NHS Ayrshire & Arran: Derek McLaughlan, Judith Ramsey, Sharon Meehan; University Hospital Lewisham, Lewisham and Greenwich NHS Trust: Bernd Oliver Rose, Rosie Reece-Anthony, Babita Gurung; University Hospitals Birmingham NHS Foundation Trust: Tony Whitehouse, Catherine Snelson, Tonny Veenith, Andy Johnston, Lauren Cooper, Ron Carrera, Karen Ellis, Emma Fellows, Samanth Harkett, Colin Bergin, Elaine Spruce, Liesl Despy, Stephanie Goundry, Natalie Dooley, Tracy Mason, Amy Clark; University Hospitals Coventry and Warwickshire NHS Trust: Gemma Dignam, Geraldine Ward; Warwick Hospital, South Warwickshire NHS Trust: Ben Attwood, Penny Parsons, Sophie Mason; St. Richard's Hospital, Western, Sussex Hospitals NHS Foundation Trust: Michael Margarson, Jenny Lord, Philip McGlone; Worthing Hospital, Western Sussex Hospitals NHS Foundation Trust: Luke E. Hodgson, Indra Chadbourn, Raquel Gomez, Jordi Margalef; York Teaching Hospital NHS Foundation Trust: Rinus Pretorius, Alexandra Hamshere, Joseph Carter, Hazel Cahill, Lia Grainger, Kate Howard, Greg Forshaw, Zoe Guy. United States: Mayo Clinic, Rochester: Kianoush B. Kashani, Robert C. Albright Jr., Amy Amsbaugh, Anita Stoltenberg, Alexander S. Niven; Rhode Island Hospital: Matthew Lynch, AnnMarie O’Mara, Syed Naeem, Sairah Sharif, Joyce McKenney Goulart; The Miriam Hospital: Matthew Lynch, AnnMarie O’Mara, Syed Naeem, Sairah Sharif, Joyce McKenney Goulart; University of Alabama at Birmingham: Ashita Tolwani, Claretha Lyas, Laura Latta; University of Florida: Azra Bihorac, Haleh Hashemighouchani, Philip Efron, Matthew Ruppert, Julie Cupka, Sean Kiley, Joshua Carson, Peggy White, George Omalay, Sherry Brown, Laura Velez, Alina zMarceron; University of Kentucky: Javier A. Neyra, Juan Carlos Aycinena, Madona Elias, Victor M. Ortiz-Soriano, Caroline Hauschild, Robert Dorfman.

Funding

The STARRT-AKI trial was funded by the following sources: Canadian Institutes of Health Research (Open Operating Grant MOP142296 and Project Grant 389635); Canadian Institutes of Health Research in partnership with Baxter (Industry-Partnered Operating Grant IPR 139081); National Health Medical Research Council of Australia (Project Grant 1127121); the Health Research Council of New Zealand (Project Grant 17/204) and the National Institutes of Health Research Health Technology Assessment Program (United Kingdom) (Reference Number: 17/42/74).

Author information

Author notes

  1. Ron Wald, Stephane Gaudry, Didier Dreyfuss and Sean M. Bagshaw contributed equally to this work.

Authors and Affiliations

  1. Division of Nephrology, St. Michael’s Hospital, University of Toronto, Li Ka Shing Knowledge Institute, Toronto, ON, Canada

    Ron Wald

  2. AP-HP, Hôpital Avicenne, Service de Réanimation Médico-Chirurgicale, UFR SMBH, Université Sorbonne Paris Nord, Bobigny, France

    Stephane Gaudry

  3. UMR S1155, French National Institute of Health and Medical Research (INSERM), CORAKID, Hôpital Tenon, Sorbonne Université, 75020, Paris, France

    Stephane Gaudry & Didier Dreyfuss

  4. Clinical Trial Service Unit and Epidemiological Studies Unit (CTSU), Nuffield Department of Population Health, University of Oxford, Oxford, UK

    Bruno R. da Costa

  5. Department of Critical Care Medicine, Sunnybrook Health Sciences Centre and University of Toronto, Toronto, Canada

    Neill K. J. Adhikari

  6. Department of Intensive Care, Austin Hospital, Melbourne, Australia

    Rinaldo Bellomo

  7. Department of Intensive Care, Royal Melbourne Hospital, Melbourne, Australia

    Rinaldo Bellomo

  8. School of Medicine, The University of Melbourne, Melbourne, Australia

    Rinaldo Bellomo

  9. Australian and New Zealand Intensive Care Research Centre, School of Public Health and Preventive Medicine, Monash University, Melbourne, Australia

    Rinaldo Bellomo

  10. Department of Critical Care Medicine, Peking Union Medical College Hospital, Bei**g, China

    Bin Du

  11. The George Institute for Global Health, University of New South Wales, Kensington, NSW, Australia

    Martin P. Gallagher

  12. Intensive Care Unit, Department of Internal Medicine and Pediatrics, Ghent University Hospital, Ghent University, Ghent, Belgium

    Eric A. Hoste

  13. Department of Medicine, Université de Sherbrooke, Centre de Recherche du CHU de Sherbrooke, Sherbrooke, QC, Canada

    François Lamontagne

  14. Division of Intensive Care and Emergency Medicine, Department of Internal Medicine, Medical University Innsbruck, Innsbruck, Austria

    Michael Joannidis

  15. Division of Intensive Care and Nephrology, University of California San Francisco, San Francisco, CA, USA

    Kathleen D. Liu

  16. The Regional Intensive Care Unit, The Wellcome-Wolfson Institute for Experimental Medicine, Queen’s University, Royal Victoria Hospital, Belfast, UK

    Daniel F. McAuley

  17. Cardiothoracic and Vascular Intensive Care Unit, Auckland City Hospital, Auckland and Medical Research Institute of New Zealand, Wellington, New Zealand

    Shay P. McGuinness

  18. Department of Critical Care Medicine, University College Dublin Clinical Research Centre at St. Vincent’s University Hospital, Dublin, Ireland

    Alistair D. Nichol

  19. Monash University, Melbourne, Australia

    Alistair D. Nichol

  20. Department of Critical Care Medicine, King’s College London, Guy’s & St Thomas Hospital, London, UK

    Marlies Ostermann

  21. Renal-Electrolyte Division, Department of Medicine, University of Pittsburgh, Pittsburgh, PA, USA

    Paul M. Palevsky

  22. Kidney Medicine Section, VA Pittsburgh Healthcare System, Pittsburgh, PA, USA

    Paul M. Palevsky

  23. Department of Critical Care Medicine, Zhongda Hospital Southeast University, Nan**g, China

    Haibo Qiu

  24. Division of Intensive Care Medicine, Department of Perioperative, Intensive Care and Pain Medicine, University of Helsinki and Helsinki University Hospital, Helsinki, Finland

    Ville Pettilä

  25. Department of Critical Care Medicine Centre, Hospitalier Universitaire Vaudois, Lausanne, Switzerland

    Antoine G. Schneider

  26. Department of Critical Care, Li Ka Shing Knowledge Institute, St. Michael’s Hospital, Toronto, Canada

    Orla M. Smith

  27. Department of Intensive Care Medicine, Department of Anesthesiology, Intensive Care and Pain Medicine, University of Helsinki and Helsinki University Hospital, Helsinki, Finland

    Suvi T. Vaara

  28. Division of Nephrology, London Health Sciences Centre, London, ON, Canada

    Matthew Weir

  29. Service de Médecine Intensive Réanimation, Sorbonne Université, Hôpital Louis Mourier, Assistance Publique, Université de Paris-Cité, Paris, France

    Didier Dreyfuss

  30. Department of Critical Care Medicine, Faculty of Medicine and Dentistry, University of Alberta, and Alberta Health Services, Edmonton, AB, Canada

    Sean M. Bagshaw

Authors
  1. Ron Wald
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Stephane Gaudry
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Bruno R. da Costa
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Neill K. J. Adhikari
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Rinaldo Bellomo
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Bin Du
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Martin P. Gallagher
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. Eric A. Hoste
    View author publications

    You can also search for this author in PubMed Google Scholar

  9. François Lamontagne
    View author publications

    You can also search for this author in PubMed Google Scholar

  10. Michael Joannidis
    View author publications

    You can also search for this author in PubMed Google Scholar

  11. Kathleen D. Liu
    View author publications

    You can also search for this author in PubMed Google Scholar

  12. Daniel F. McAuley
    View author publications

    You can also search for this author in PubMed Google Scholar

  13. Shay P. McGuinness
    View author publications

    You can also search for this author in PubMed Google Scholar

  14. Alistair D. Nichol
    View author publications

    You can also search for this author in PubMed Google Scholar

  15. Marlies Ostermann
    View author publications

    You can also search for this author in PubMed Google Scholar

  16. Paul M. Palevsky
    View author publications

    You can also search for this author in PubMed Google Scholar

  17. Haibo Qiu
    View author publications

    You can also search for this author in PubMed Google Scholar

  18. Ville Pettilä
    View author publications

    You can also search for this author in PubMed Google Scholar

  19. Antoine G. Schneider
    View author publications

    You can also search for this author in PubMed Google Scholar

  20. Orla M. Smith
    View author publications

    You can also search for this author in PubMed Google Scholar

  21. Suvi T. Vaara
    View author publications

    You can also search for this author in PubMed Google Scholar

  22. Matthew Weir
    View author publications

    You can also search for this author in PubMed Google Scholar

  23. Didier Dreyfuss
    View author publications

    You can also search for this author in PubMed Google Scholar

  24. Sean M. Bagshaw
    View author publications

    You can also search for this author in PubMed Google Scholar

Consortia

the STARRT-AKI Investigators

  • Sean M. Bagshaw
  • , Ron Wald
  • , Neill K. J. Adhikari
  • , Rinaldo Bellomo
  • , Didier Dreyfuss
  • , Bin Du
  • , Martin P. Gallagher
  • , Stéphane Gaudry
  • , Eric A. Hoste
  • , François Lamontagne
  • , Michael Joannidis
  • , Kathleen D. Liu
  • , Daniel F. McAuley
  • , Shay P. McGuinness
  • , Alistair D. Nichol
  • , Marlies Ostermann
  • , Paul M. Palevsky
  • , Haibo Qiu
  • , Ville Pettilä
  • , Antoine G. Schneider
  • , Orla M. Smith
  • , Suvi T. Vaara
  • , Matthew Weir
  • , Rinaldo Bellomo
  • , Glenn M. Eastwood
  • , Leah Peck
  • , Helen Young
  • , Peter Kruger
  • , Gordon Laurie
  • , Emma Saylor
  • , Jason Meyer
  • , Ellen Venz
  • , Krista Wetzig
  • , Craig French
  • , Forbes McGain
  • , John Mulder
  • , Gerard Fennessy
  • , Sathyajith Koottayi
  • , Samantha Bates
  • , Miriam Towns
  • , Rebecca Morgan
  • , Anna Tippett
  • , Andrew Udy
  • , Chris Mason
  • , Elisa Licari
  • , Dashiell Gantner
  • , Jason McClure
  • , Alistair Nichol
  • , Phoebe McCracken
  • , Jasmin Board
  • , Emma Martin
  • , Shirley Vallance
  • , Meredith Young
  • , Chelsey Vladic
  • , Steve McGloughlin
  • , David Gattas
  • , Heidi Buhr
  • , Jennifer Coles
  • , Debra Hutch
  • , James Wun
  • , Louise Cole
  • , Christina Whitehead
  • , Julie Lowrey
  • , Kristy Masters
  • , Rebecca Gresham
  • , Victoria Campbell
  • , David Gutierrez
  • , Jane Brailsford
  • , Loretta Forbes
  • , Lauren Murray
  • , Teena Maguire
  • , Martina NiChonghaile
  • , Neil Orford
  • , Allison Bone
  • , Tania Elderkin
  • , Tania Salerno
  • , Tim Chimunda
  • , Jason Fletcher
  • , Emma Broadfield
  • , Sanjay Porwal
  • , Cameron Knott
  • , Catherine Boschert
  • , Julie Smith
  • , Angus Richardson
  • , Dianne Hill
  • , Graeme Duke
  • , Peter Oziemski
  • , Santiago Cegarra
  • , Peter Chan
  • , Deborah Welsh
  • , Stephanie Hunter
  • , Owen Roodenburg
  • , John Dyett
  • , Nicos Kokotsis
  • , Max Moser
  • ,  Yang
  • , Laven Padayachee
  • , Joseph Vetro
  • , Himangsu Gangopadhyay
  • , Melissa Kaufman
  • , Angaj Ghosh
  • , Simone Said
  • , Alpesh Patel
  • , Shailesh Bihari
  • , Elisha Matheson
  • , ** Lu
  • , Yingtao Lian
  • , Chunting Wang
  • , Jichen Zhang
  • , Ruiqi Ding
  • , Guoqing Qi
  • , Qizhi Wang
  • , Peng Wang
  • , Zhaoli Meng
  • , Man Chen
  • , ** Zhao
  • , Chenghuan Hu
  • , **g Li
  • , Fuxing Deng
  • , Haibo Qui
  • , Yi Yang
  • , Min Mo
  • , Chun Pan
  • , Changde Wu
  • , Yingzi Huang
  • , Lili Huang
  • , Airan Liu
  • , Ville Pettilä
  • , Suvi T. Vaara
  • , Anna-Maija Korhonen
  • , Sanna Törnblom
  • , Sari Sutinen
  • , Leena Pettilä
  • , Jonna Heinonen
  • , Eliria Lappi
  • , Taria Suhonen
  • , Sari Karlsson
  • , Sanna Hoppu
  • , Ville Jalkanen
  • , Anne Kuitunen
  • , Markus Levoranta
  • , Jaakko Långsjö
  • , Sanna Ristimäki
  • , Kaisa Malila
  • , Anna Wootten
  • , Simo Varila
  • , Mikko J Järvisalo
  • , Outi Inkinen
  • , Satu Kentala
  • , Keijo Leivo
  • , Paivi Haltia
  • , Didier Dreyfuss
  • , Jean-Damien Ricard
  • , Jonathan Messika
  • , Abirami Tiagarajah
  • , Malo Emery
  • , Aline Dechanet
  • , Coralie Gernez
  • , Damien Roux
  • , Laurent Martin-Lefevre
  • , Maud Fiancette
  • , Isabelle Vinatier
  • , Jean Claude Lacherade
  • , Gwenhaël Colin
  • , Christine Lebert
  • , Marie-Ange Azais
  • , Aihem Yehia
  • , Caroline Pouplet
  • , Matthieu Henry- Lagarrigue
  • , Amélie Seguin
  • , Laura Crosby
  • , Julien Maizel
  • , Dimitri Titeca-Beauport
  • , Alain Combes
  • , Ania Nieszkowska
  • , Paul Masi
  • , Alexandre Demoule
  • , Julien Mayaux
  • , Martin Dres
  • , Elise Morawiec
  • , Maxens Decalvele
  • , Suela Demiri
  • , Morgane Faure
  • , Clémence Marios
  • , Maxime Mallet
  • , Marie Amélie Ordon
  • , Laura Morizot
  • , Marie Cantien
  • , François Pousset
  • , Stéphane Gaudry
  • , Florent Poirson
  • , Yves Cohen
  • , Laurent Argaud
  • , Martin Cour
  • , Laurent Bitker
  • , Marie Simon
  • , Romain Hernu
  • , Thomas Baudry
  • , Sylvie De La Salle
  • , Adrien Robine
  • , Nicholas Sedillot
  • , Xavier Tchenio
  • , Camille Bouisse
  • , Sylvie Roux
  • , Saber Davide Barbar
  • , Rémi Trusson
  • , Fabienne Tamion
  • , Steven Grangé
  • , Dorothée Carpentier
  • , Guillaume Chevrel
  • , Luis Ensenyat-Martin
  • , Sophie Marque
  • , Jean-Pierre Quenot
  • , Pascal Andreu
  • , Auguste Dargent
  • , Audrey Large
  • , Nicolas Chudeau
  • , Mickael Landais
  • , Benoit Derrien
  • , Jean Christophe Callahan
  • , Christophe Guitton
  • , Charlène Le Moal
  • , Alain Robert
  • , Karim Asehnoune
  • , Raphaël Cinotti
  • , Nicolas Grillot
  • , Dominique Demeure
  • , Christophe Vinsonneau
  • , Imen Rahmani
  • , Mehdi Marzouk
  • , Thibault Dekeyser
  • , Caroline Sejourne
  • , Mélanie Verlay
  • , Fabienne Thevenin
  • , Lucie Delecolle
  • , Didier Thevenin
  • , Bertrand Souweine
  • , Elisabeth Coupez
  • , Mireille Adda
  • , Jean-Pierre Eraldi
  • , Antoine Marchalot
  • , Nicolas De Prost
  • , Armand Mekontso Dessap
  • , Keyvan Razazi
  • , Ferhat Meziani
  • , Julie Boisrame-Helms
  • , Raphael Clere-Jehl
  • , Xavier Delabranche
  • , Christine Kummerlen
  • , Hamid Merdji
  • , Alexandra Monnier
  • , Yannick Rabouel
  • , Hassene Rahmani
  • , Hayat Allam
  • , Samir Chenaf
  • , Vincenta Franja
  • , Bertrand Pons
  • , Michel Carles
  • , Frédéric Martino
  • , Régine Richard
  • , Benjamin Zuber
  • , Guillaume Lacave
  • , Karim Lakhal
  • , Bertrand Rozec
  • , Hoa Dang Van
  • , Éric Boulet
  • , Fouad Fadel
  • , Cedric Cleophax
  • , Nicolas Dufour
  • , Caroline Grant
  • , Marie Thuong
  • , Jean Reignier
  • , Emmanuel Canet
  • , Laurent Nicolet
  • , Thierry Boulain
  • , Mai-Anh Nay
  • , Dalila Benzekri
  • , François Barbier
  • , Anne Bretagnol
  • , Toufik Kamel
  • , Armelle Mathonnet
  • , Grégoire Muller
  • , Marie Skarzynski
  • , Julie Rossi
  • , Amandine Pradet
  • , Sandra Dos Santos
  • , Aurore Guery
  • , Lucie Muller
  • , Luis Felix
  • , Julien Bohé
  • , Guillaume Thiéry
  • , Nadia Aissaoui
  • , Damien Vimpere
  • , Morgane Commeureuc
  • , Jean-Luc Diehl
  • , Emmanuel Guerot
  • , Orfeas Liangos
  • , Monika Wittig
  • , Alexander Zarbock
  • , Mira Küllmar
  • , Thomas van Waegeningh
  • , Nadine Rosenow
  • , Alistair D. Nichol
  • , Kathy Brickell
  • , Peter Doran
  • , Patrick T. Murray
  • , Giovanni Landoni
  • , Rosalba Lembo
  • , Alberto Zangrillo
  • , Giacomo Monti
  • , Margherita Tozzi
  • , Matteo Marzaroli
  • , Gaetano Lombardi
  • , Gianluca Paternoster
  • , Michelangelo Vitiello
  • , Shay McGuinness
  • , Rachael Parke
  • , Magdalena Butler
  • , Eileen Gilder
  • , Keri-Anne Cowdrey
  • , Samantha Wallace
  • , Jane Hallion
  • , Melissa Woolett
  • , Philippa Neal
  • , Karina Duffy
  • , Stephanie Long
  • , Colin McArthur
  • , Catherine Simmonds
  • , Yan Chen
  • , Rachael McConnochie
  • , Lynette Newby
  • , David Knight
  • , Seton Henderson
  • , Jan Mehrtens
  • , Stacey Morgan
  • , Anna Morris
  • , Kymbalee Vander Hayden
  • , Tara Burke
  • , Matthew Bailey
  • , Ross Freebairn
  • , Lesley Chadwick
  • , Penelope Park
  • , Christine Rolls
  • , Liz Thomas
  • , Ulrike Buehner
  • , Erin Williams
  • , Jonathan Albrett
  • , Simon Kirkham
  • , Carolyn Jackson
  • , Troy Browne
  • , Jennifer Goodson
  • , David Jackson
  • , James Houghton
  • , Owen Callender
  • , Vicki Higson
  • , Owen Keet
  • , Clive Dominy
  • , Paul Young
  • , Anna Hunt
  • , Harriet Judd
  • , Cassie Lawrence
  • , Shaanti Olatunji
  • , Yvonne Robertson
  • , Charlotte Latimer-Bell
  • , Deborah Hendry
  • , Agnes Mckay-Vucago
  • , Nina Beehre
  • ,  Eden
  • ,  Lesona
  • , Leanlove Navarra
  • , Chelsea Robinson
  • , Ryan Jang
  • , Andrea Junge
  • , Bridget Lambert
  • , Antoine G. Schneider
  • , Michel Thibault
  • , Philippe Eckert
  • , Sébastien Kissling
  • , Erietta Polychronopoulos
  • , Elettra Poli
  • , Marco Altarelli
  • , Madeleine Schnorf
  • , Samia Abed Mallaird
  • , Claudia Heidegger
  • , Aurelie Perret
  • , Philippe Montillier
  • , Frederic Sangla
  • , Seigenthaller Neils
  • , Aude De Watteville
  • , Mandeep-Kaur Phull
  • , Aparna George
  • , Nauman Hussain
  • , Tatiana Pogreban
  • , Steve Lobaz
  • , Alison Daniels
  • , Mishell Cunningham
  • , Deborah Kerr
  • , Alice Nicholson
  • , Pradeep Shanmugasundaram
  • , Judith Abrams
  • , Katarina Manso
  • , Geraldine Hambrook
  • , Elizabeth McKerrow
  • , Juvy Salva
  • , Stephen Foulkes
  • , Matthew Wise
  • , Matt Morgan
  • , Jenny Brooks
  • , Jade Cole
  • , Tracy Michelle Davies
  • , Helen Hill
  • , Emma Thomas
  • , Marcela Vizcaychipi
  • , Behrad Baharlo
  • , Jaime Carungcong
  • , Patricia Costa
  • , Laura Martins
  • , Ritoo Kapoor
  • , Tracy Hazelton
  • , Angela Moon
  • , Janine Musselwhite
  • , Ben Shelley
  • , Philip McCall
  • , Marlies Ostermann
  • , Gill Arbane
  • , Aneta Bociek
  • , Martina Marotti
  • , Rosario Lim
  • , Sara Campos
  • , Neus Grau Novellas
  • , Armando Cennamo
  • , Andrew Slack
  • , Duncan Wyncoll
  • , Luigi Camporota
  • , Simon Sparkes
  • , Rosalinde Tilley
  • , Austin Rattray
  • , Gayle Moreland
  • , Jane Duffy
  • , Elizabeth McGonigal
  • , Philip Hopkins
  • , Clare Finney
  • , John Smith
  • , Harriet Noble
  • , Hayley Watson
  • , Claire-Louise Harris
  • , Emma Clarey
  • , Eleanor Corcoran
  • , James Beck
  • , Clare Howcroft
  • , Nora Youngs
  • , Elizabeth Wilby
  • , Bethan Ogg
  • , Adam Wolverson
  • , Sandra Lee
  • , Susie Butler
  • , Maryanne Okubanjo
  • , Julia Hindle
  • , Ingeborg Welters
  • , Karen Williams
  • , Emily Johnson
  • , Julie Patrick-Heselton
  • , David Shaw
  • , Victoria Waugh
  • , Richard Stewart
  • , Esther Mwaura
  • , Lynn Wren
  • , Louise Mew
  • , Sara-Beth Sutherland
  • , Jane Adderley
  • , Jim Ruddy
  • , Margaret Harkins
  • , Callum Kaye
  • , Teresa Scott
  • , Wendy Mitchell
  • , Felicity Anderson
  • , Fiona Willox
  • , Vijay Jagannathan
  • , Michele Clark
  • , Sarah Purv
  • , Andrew Sharman
  • , Megan Meredith
  • , Lucy Ryan
  • , Louise Conner
  • , Cecilia Peters
  • , Dan Harvey
  • , Ashraf Roshdy
  • , Amy Collins
  • , Malcolm Sim
  • , Steven Henderson
  • , Nigel Chee
  • , Sally Pitts
  • , Katie Bowman
  • , Maria Dilawershah
  • , Luke Vamplew
  • , Elizabeth Howe
  • , Paula Rogers
  • , Clara Hernandez
  • , Clara Prendergast
  • , Jane Benton
  • , Alex Rosenberg
  • , Lui G. Forni
  • , Alice Grant
  • , Paula Carvelli
  • , Ajay Raithatha
  • , Sarah Bird
  • , Max Richardson
  • , Matthew Needham
  • , Claire Hirst
  • , Jonathan Ball
  • , Susannah Leaver
  • , Luisa Howlett
  • , Carlos Castro Delgado
  • , Sarah Farnell-Ward
  • , Helen Farrah
  • , Geraldine Gray
  • , Gipsy Joseph
  • , Francesca Robinson
  • , Ascanio Tridente
  • , Clare Harrop
  • , Karen Shuker
  • , Derek McLaughlan
  • , Judith Ramsey
  • , Sharon Meehan
  • , Bernd Oliver Rose
  • , Rosie Reece-Anthony
  • , Babita Gurung
  • , Tony Whitehouse
  • , Catherine Snelson
  • , Tonny Veenith
  • , Andy Johnston
  • , Lauren Cooper
  • , Ron Carrera
  • , Karen Ellis
  • , Emma Fellows
  • , Samanth Harkett
  • , Colin Bergin
  • , Elaine Spruce
  • , Liesl Despy
  • , Stephanie Goundry
  • , Natalie Dooley
  • , Tracy Mason
  • , Amy Clark
  • , Gemma Dignam
  • , Geraldine Ward
  • , Ben Attwood
  • , Penny Parsons
  • , Sophie Mason
  • , Michael Margarson
  • , Jenny Lord
  • , Philip McGlone
  • , Luke E. Hodgson
  • , Indra Chadbourn
  • , Raquel Gomez
  • , Jordi Margalef
  • , Rinus Pretorius
  • , Alexandra Hamshere
  • , Joseph Carter
  • , Hazel Cahill
  • , Lia Grainger
  • , Kate Howard
  • , Greg Forshaw
  • , Zoe Guy
  • , Kianoush B. Kashani
  • , Robert C. Albright Jr.
  • , Amy Amsbaugh
  • , Anita Stoltenberg
  • , Alexander S. Niven
  • , Matthew Lynch
  • , AnnMarie O’Mara
  • , Syed Naeem
  • , Sairah Sharif
  • , Joyce McKenney Goulart
  • , Matthew Lynch
  • , AnnMarie O’Mara
  • , Syed Naeem
  • , Sairah Sharif
  • , Joyce McKenney Goulart
  • , Ashita Tolwani
  • , Claretha Lyas
  • , Laura Latta
  • , Azra Bihorac
  • , Haleh Hashemighouchani
  • , Philip Efron
  • , Matthew Ruppert
  • , Julie Cupka
  • , Sean Kiley
  • , Joshua Carson
  • , Peggy White
  • , George Omalay
  • , Sherry Brown
  • , Laura Velez
  • , Alina zMarceron
  • , Javier A. Neyra
  • , Juan Carlos Aycinena
  • , Madona Elias
  • , Victor M. Ortiz-Soriano
  • , Caroline Hauschild
  •  & Robert Dorfman

Contributions

RW, SG, DD and SMB conceived and designed the study in consultation with the Steering Committee. RW, SG, DD and SMB drafted the data creation plan. BRdC performed the analysis; all authors interpreted the data; RW and SMB drafted the manuscript; all authors provided substantial revisions; all authors have reviewed and approved the submitted manuscript; all authors have agreed both to be personally accountable for the author's own contributions and to ensure that questions related to the accuracy or integrity of any part of the work, even ones in which the author was not personally involved, are appropriately investigated, resolved, and the resolution documented in the literature.

Corresponding author

Correspondence to Ron Wald.

Ethics declarations

Conflicts of Interest

SMB has received fees from Baxter for scientific advisory and speaking; fees from BioPorto for scientific advisory and clinical adjudication; fees from Novartis for scientific advisory; and fees from I-SPY-COVID for Data Safety Monitoring. RW has received unrestricted research funding and speaker fees from Baxter. RW has received consulting fees and unrestricted research funding from Baxter.

Ethical approval

The STARRT-AKI trial was approved by the research ethics boards at the University of Alberta (File # Pro00060023) and Unity Health Toronto (CTO Project ID: 0761) and at each participating site. Depending on local standards and legislation, informed consent was obtained from patients and substitute decision-makers or through waived consent.

Consent for publication

Not applicable.

Additional information

Publisher's Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

STARRT-AKI investigators listed in the Acknowledgement section.

Supplementary Information

Below is the link to the electronic supplementary material.

Supplementary file1 (DOCX 48 KB)

Rights and permissions

Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Wald, R., Gaudry, S., da Costa, B.R. et al. Initiation of continuous renal replacement therapy versus intermittent hemodialysis in critically ill patients with severe acute kidney injury: a secondary analysis of STARRT-AKI trial. Intensive Care Med 49, 1305–1316 (2023). https://doi.org/10.1007/s00134-023-07211-8

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00134-023-07211-8

Keywords

Search

Navigation