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Nitrogenous phytoconstituents of genus Moringa: spectrophotometrical and pharmacological characteristics

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Abstract

Moringa Adans. (Moringaceae) is a multipurpose plant showing uncountable uses due to nutritional, folklore, and pharmacological worldwide applications. Moringa is rich in nitrogenous compounds, viz., glucosinolates, thiocarbamates, cyanogens, isothiocyanates, and alkaloids. Plants of this genus are a good source of vitamins, β-carotene, proteins, and various phenolics. This review focuses on spectrophotometrical characteristics of nitrogenous compounds along with their pharmacological properties. Aligning traditional usage with scientific assessment, Moringa have compounds with a great commercial potential especially nitrogenous compounds. We hope to support a new research on Moringa, especially on those species whose biological properties have not been studied to date moreover explore the mechanisms at the molecular level.

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References

  • Anwar F, Rashid U (2007) Physico-chemical characteristics of Moringa oleifera seeds and seed oil from a wild provenance of Pakistan. Pak J Bot 39(5):1443–1453

    Google Scholar 

  • Ayyari M et al. (2014) Antitrypanosomal isothiocyanate and thiocarbamate glycosides from Moringa oleifera. Planta Medica 80(01):86–89

    CAS  PubMed  Google Scholar 

  • Baky H, El-baroty G (2013) Characterization of Egyptian Moringa peregrine seed oil and its bioactivities. Int J Manag Sci Bus Res 2(7):98–108

  • Bichi M (2013) A review of the applications of Moringa oleifera seeds extract in water treatment. Civ Environ Res 3:1–11

    Google Scholar 

  • Brown J, Morra M (2005) Glucosinolate containing seed meal as a soil amendment to control plant pests. National Renewable Energy Laboratory, Golden, CO (US)

  • Brunelli D et al. (2010) The isothiocyanate produced from glucomoringin inhibits NF-KB and reduces myeloma growth in nude mice in vivo. Biochem Pharmacol 79(8):1141–1148

    Article  CAS  PubMed  Google Scholar 

  • Cheenpracha S et al. (2010) Potential anti-inflammatory phenolic glycosides from the medicinal plant Moringa oleifera fruits. Bioorganic Med Chem 18(17):6598–6602

    Article  CAS  Google Scholar 

  • Chen G, Yang M, Kuo P, Lin M, Liao M (2014) Chemical constituents of Moringa oleifera and their cytotoxicity aganist doxorubicin-resistant human. Chem Nat Compd 50:154–156

    Google Scholar 

  • Chen K-H et al. (2012) Attenuation of the extract from Moringa oleifera on monocrotaline-induced pulmonary hypertension in rats. Chin J Physiol 55(1):22–30

    Article  CAS  PubMed  Google Scholar 

  • Eilert U, Wolters B, Nahrstedt A (1981) The antibiotic principle of seeds of Moringa oleifera and Moringa stenopetala. Planta Med 42:55–61

    Article  CAS  PubMed  Google Scholar 

  • Fahey J, Zalcmann A, Talalay P (2001) The chemical diversity and distribution of glucosinolates and isothiocyanates among plants. Phytochemistry 56:5–51

    Article  CAS  PubMed  Google Scholar 

  • Faizi S et al. (1992) Isolation and structure elucidation of novel hypotensive agents, niazinin A, niazinin B, niazimicin and niaziminin A+ B from Moringa oleifera: The first naturally occurring thiocarbamates. J Chem Soc Perkin Trans 63:3237–3241

    Article  Google Scholar 

  • Faizi S et al. (1998) Hypotensive constituents from the pods of Moringa oleifera. Planta Med 64(03):225–228

    Article  CAS  PubMed  Google Scholar 

  • Faizi S, Siddiqui B, Saleem R, Aftab K, Shaheen F, Gilani A (1998) Hypotensive constituents from the pods of Moringa oleifera. Planta Med 64:225–228

    Article  CAS  PubMed  Google Scholar 

  • Faizi S, Siddiqui S, Saleem R, Husnain S, Noor F (1997) Isolation and structure elucidation of a novel glycoside niazidin from the pods of Moringa oleifera. J Nat Prod 60:1317–1321

    Article  CAS  Google Scholar 

  • Faizi S, Siddiqui B, Saleem R, Siddiqui S, Aftaba K, Gilani A (1994) Novel hypotensive agents, niazimin A, niazimin B, niazicin A and niazicin B from Moringa oleifera: isolation of first naturally occurring carbarnates. J Chem Soc Perkin Trans 57:168–170

  • Faizi S, Siddiqui S, Saleem R, Siddiqui S, Aftab K (1994) Isolation and structure elucidation of new nitrile and mustard oil glycosides from Moringa oleifera and their effect on blood pressure. J Nat Prod 5:1256–1261

    Article  Google Scholar 

  • Faizi S, Siddiqui S, Saleem R, Siddiqui S, Aftab K, Gilani A (1995) Fully acetylated carbamate and hypotensive thiocarbamate glycosides from Moringa oleifera. Phytochemistry 38:2–8

    Article  Google Scholar 

  • Galuppo M et al. (2015) 4 (α-L-rhamnosyloxy)-benzyl isothiocyanate, a bioactive phytochemical that defends cerebral tissue and prevents severe damage induced by focal ischemia/reperfusion. J Biol Regul Homeost Agents 29:343–356

    CAS  PubMed  Google Scholar 

  • Galuppo M et al. (2015) Administration of 4-(α-L-rhamnosyloxy)-benzyl isothiocyanate delays disease phenotype in SOD1G93A rats: a transgenic model of amyotrophic lateral sclerosis. BioMed Res Int 2015:1–12

  • Gilani A, Aftab K, Suria A, Siddiqui S, Salem R, Siddiqui S, Faizi S (1994) Pharmacological studies on hypotensive and spasmolytic activities of pure compounds from Moringa oleifera. Phytother Res 8:87–91

    Article  CAS  Google Scholar 

  • Guevara A, Vargas C, Sakurai H, Fujiwara Y, Hashimoto K, Maoka T, Kozuka M, Ito Y, Tokuda H, Nishino H (1999) An antitumor promoter from Moringa oleifera lam. Mutat Res/Genet Toxicol Environ Mutagen 440:181–188

    Article  CAS  Google Scholar 

  • Gueyrard, D et al. (2002) Isolation and synthesis of 4-rhamno-glucosinalbin, the major glucosinolate from Moringa oleifera. In: Natural products in the new millennium: prospects and industrial application. Springer, Dordrecht, p 415–419

  • Gupta S, Khanuja S, Shasany A, Darokar M (2005) Novel nitrile glycoside (niaziridin) useful as a bio-enhancer of drugs and nutrients, process of its isolation from Moringa oleifera. U.S. Patent No. 6,858,588

  • Maldini M et al. (2014) Moringa oleifera: study of phenolics and glucosinolates by mass spectrometry. J Mass Spectrom 49(9):900–910

    Article  CAS  PubMed  Google Scholar 

  • Murakami A, Kitazono Y, Jiwa**da S, Koshimizu K, Ohigashi H (1998) Niaziminin, a thiocarbamate from the leaves of Moringa oleifera, holds a strict structural requirement for inhibition of tumor-promoter-induced Epstein–Barr virus activation. Planta Med 64:319–323

    Article  CAS  PubMed  Google Scholar 

  • Nikkon F, Saud Z, Rahman M, Haque M (2003) in vitro antimicrobial activity of the compound isolated from chloroform extract of Moringa oleifera lam. Pak J Biol Sci 6:1888–1890

    Article  Google Scholar 

  • Olson M (2002) Intergeneric relationships within the Caricaceae-Moringaceae Clade (Brassicales) and potential morphological synapomorphies of the clade and its families. Int J Plant Sci 163:51–65

    Article  CAS  Google Scholar 

  • Onyango L, Manguro A, Lemmen P (2007) Phenolics of Moringa oleifera leaves. Nat Prod Res 21:56–68

    Article  CAS  Google Scholar 

  • Park E-J et al. (2011) Inhibition of lipopolysaccharide-induced cyclooxygenase-2 and inducible nitric oxide synthase expression by 4-[(2′-O-acetyl-α-L-rhamnosyloxy) benzyl] isothiocyanate from Moringa oleifera. Nutr Cancer 63(6):971–982

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Price M (1985) The Moringa Tree. ECHO Technical Note. Educational Concerns for Hunger Organization, N. Ft. Meyers, FL

  • Rani A, Zahirah N, Husain K, Kumolosasi E (2018) Moringa genus: a review of phytochemistry and pharmacology. Front Pharmacol 9:108

    Article  CAS  Google Scholar 

  • Sahakitpichan P, Mahidol C, Disadee W, Ruchirawat S, Kanchanapoom T (2011) Unusual glycosides of pyrrole alkaloid and 4/-hydroxyphenylethanamide from leaves of Moringa oleifera. Phytochemistry 72:791–795

    Article  CAS  PubMed  Google Scholar 

  • Sashidhara K, Rosaiah J, Tyagi E, Shukla R, Raghubir R, Rajendran S (2009) Rare Dipeptide and urea derivatives from roots of Moringa oleifera as potential anti-inflammatory and antinociceptive agents. Eur J Med Chem 44:432–436

    Article  CAS  PubMed  Google Scholar 

  • Taeckholm V (1974) Students’ Flora of Egypt. Cairo University, Cooperative Printing, Beirut

  • Tiloke C, Phulukdaree A, Chuturgoon AA (2013) The antiproliferative effect of Moringa oleifera crude aqueous leaf extract on cancerous human alveolar epithelial cells. BMC Complement Altern Med 13(1):226

    Article  PubMed  PubMed Central  Google Scholar 

  • Vaughn S, Berhow M (2005) Glucosinolate hydrolysis products from various plant sources: ph effects, isolation, and purification. Ind Crops Prod 21:193–202

    Article  CAS  Google Scholar 

  • Verhoeven D, Verhagen H, Goldbohm R, van den B, Piet A, Poppel G (1997) A review of mechanisms underlying anticarcinogenicity by Brassica vegetables. Chem-Biol Interact 103:79–129

    Article  CAS  PubMed  Google Scholar 

  • Villasenor I, Lim-Sylianco C, Dayrit F (1989) Mutagens from roasted seeds of Moringa oleifera. Mutat Res/Genet Toxicol 224:209–212

    Article  CAS  Google Scholar 

  • Waterman C, Cheng D, Rojas-Silva P, Poulev A, Dreifus J, Lila M, Raskin I (2014) Stable, water extractable isothiocyanates from Moringa oleifera leaves attenuate inflammation in vitro. Phytochemistry 103:114–122

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Waterman C et al. (2015) Isothiocyanate-rich Moringa oleifera extract reduces weight gain, insulin resistance, and hepatic gluconeogenesis in mice. Mol Nutr Food Res 59(6):1013–1024

    Article  CAS  PubMed  PubMed Central  Google Scholar 

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Authors and Affiliations

  1. Department of Pharmacognosy, Faculty of Pharmacy, October 6 University, Giza, Egypt

    Alaadin E. El-Haddad, Eman M. El-Deeb & Mahmoud A. Koheil

  2. Department of Pharmacognosy, Faculty of Pharmacy, Helwan University, Cairo, Egypt

    Soad M. Abd El-Khalik

  3. Department of Pharmacognosy, Faculty of Pharmacy, Cairo University, Cairo, Egypt

    Hala M. El- Hefnawy

Authors
  1. Alaadin E. El-Haddad
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  2. Eman M. El-Deeb
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  3. Mahmoud A. Koheil
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  4. Soad M. Abd El-Khalik
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  5. Hala M. El- Hefnawy
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Correspondence to Alaadin E. El-Haddad.

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El-Haddad, A.E., El-Deeb, E.M., Koheil, M.A. et al. Nitrogenous phytoconstituents of genus Moringa: spectrophotometrical and pharmacological characteristics. Med Chem Res 28, 1591–1600 (2019). https://doi.org/10.1007/s00044-019-02403-8

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