Role of Nanoemulsion in Lung Cancer Treatment

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Current Trends in Green Nano-emulsions

Abstract

Lung cancer, a collection of dangerous malignant tumours, is one of the major contributors to new cancer cases and cancer-related mortality. Lung cancer has a bad outcome and a relatively low life expectancy due to late detection and the lack of effectiveness of traditional therapy. Thus, drug delivery techniques that might prevent harm to healthy cells, increase treatment effectiveness, and serve as imaging instruments are receiving much interest. Unique drugs based on nanoscales have been created due to advances in material science, giving patients with lung cancer fresh hope. Because of their outstanding capacities to dissolve polar anti-cancer drugs, high thermal stability, bioactivity, and target ability, nanoemulsions (NEs) represent a viable platform for cancer treatment. In the continuous phase, NEs may be able to do various tasks with their submicron dispersed colloids, which helps overcome biological barriers that prevent traditional chemotherapeutic drug delivery from reaching the target area of lung cancer. By modifying it to target the cancer cells’ surroundings better, surface-engineered NE, combined with chemotherapy, can transform the way lung cancer is treated. This chapter aims to give an overview of the role of nanoemulsion in lung cancer treatment.

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References

  1. Abdelaziz HM, Gaber M, Abd-Elwakil MM, Mabrouk MT, Elgohary MM, Kamel NM, Kabary DM, Freag MS, Samaha MW, Mortada SM, Elkhodairy KA, Fang JY, Elzoghby AO (2018) Inhalable particulate drug delivery systems for lung cancer therapy: Nanoparticles, microparticles, nanocomposites and nanoaggregates. J Control Release 269:374–392. https://doi.org/10.1016/J.JCONREL.2017.11.036

    Article  CAS  PubMed  Google Scholar 

  2. Babu A, Templeton AK, Munshi A, Ramesh R (2013) Nanoparticle-based drug delivery for therapy of lung cancer: Progress and challenges. J Nanomater. https://doi.org/10.1155/2013/863951

  3. Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA, Jemal A (2018) Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA: Cancer J Clin, 68(6), 394–424. https://doi.org/10.3322/CAAC.21492

  4. Cancer. (n.d.). Retrieved March 28, 2023, from https://www.who.int/news-room/fact-sheets/detail/cancer

  5. Chang HB, Chen BH (2015) Inhibition of lung cancer cells A549 and H460 by curcuminoid extracts and nanoemulsions prepared from—Curcuma longa—Linnaeus. Int J Nanomed 10(1):5059–5080. https://doi.org/10.2147/IJN.S87225

    Article  CAS  Google Scholar 

  6. Choudhury H, Gorain B, Chatterjee B, Mandal UK, Sengupta P, Tekade RK (2017) Pharmacokinetic and pharmacodynamic features of nanoemulsion following oral, intravenous, topical and nasal route. Curr Pharm Des, 23(17). https://doi.org/10.2174/1381612822666161201143600

  7. Choudhury H, Gorain B, Karmakar S, Biswas E, Dey G, Barik R, Mandal M, Pal TK (2014) Improvement of cellular uptake, in vitro antitumor activity and sustained release profile with increased bioavailability from a nanoemulsion platform. Int J Pharm 460(1–2):131–143. https://doi.org/10.1016/J.IJPHARM.2013.10.055

    Article  CAS  PubMed  Google Scholar 

  8. Choudhury H, Pandey M, Gorain B, Chatterjee B, Madheswaran T, Md, S, Mak K-K, Tambuwala M, Chourasia MK, Kesharwani P (2019). Nanoemulsions as effective carriers for the treatment of lung cancer. Nanotechnol-Based Target Drug Deliv Syst Lung Cancer, 217–247. https://doi.org/10.1016/B978-0-12-815720-6.00009-5

  9. Dos Santos Câmara AL, Nagel G, Tschiche HR, Cardador CM, Muehlmann LA, De Oliveira DM, Alvim PQ, Azevedo RB, Calderón M, Longo JPF (2017) Acid-sensitive lipidated doxorubicin prodrug entrapped in nanoemulsion impairs lung tumor metastasis in a breast cancer model. https://Doi.Org/https://doi.org/10.2217/Nnm-2017-0091, 12(15), 1751–1765. https://doi.org/10.2217/NNM-2017-0091

  10. Du X, Khan AR, Fu M, Ji J, Yu A, Zhai G (2018) Current development in the formulations of non-injection administration of paclitaxel. Int J Pharm 542(1–2):242–252. https://doi.org/10.1016/J.IJPHARM.2018.03.030

    Article  CAS  PubMed  Google Scholar 

  11. Fitzmaurice C, Dicker D, Pain A, Hamavid H, Moradi-Lakeh M, MacIntyre MF, Allen C, Hansen G, Woodbrook R, Wolfe C, Hamadeh RR, Moore A, Werdecker A, Gessner BD, Te Ao B, McMahon B, Karimkhani C, Yu C, Cooke GS, Naghavi M (2015) The Global Burden of Cancer 2013. JAMA Oncol 1(4):505–527. https://doi.org/10.1001/JAMAONCOL.2015.0735

    Article  PubMed  Google Scholar 

  12. Ganta S, Talekar M, Singh A, Coleman TP, Amiji MM (2014) Nanoemulsions in translational research-opportunities and challenges in targeted cancer therapy. AAPS Pharm Sci Tech 15(3):694–708. https://doi.org/10.1208/S12249-014-0088-9

    Article  CAS  Google Scholar 

  13. Hirsch FR, Suda K, Wiens J, Bunn PA (2016) New and emerging targeted treatments in advanced non-small-cell lung cancer. Lancet (London, England) 388(10048):1012–1024. https://doi.org/10.1016/S0140-6736(16)31473-8

    Article  PubMed  Google Scholar 

  14. Huang CY, Ju DT, Chang CF, Muralidhar Reddy P, Velmurugan BK (2017) A review on the effects of current chemotherapy drugs and natural agents in treating non-small cell lung cancer. Biomedicine 7(4):12–23. https://doi.org/10.1051/BMDCN/2017070423

    Article  Google Scholar 

  15. Hwang YY, Ramalingam K, Bienek DR, Lee V, You T, Alvarez R (2013) Antimicrobial activity of nanoemulsion in combination with cetylpyridinium chloride in multidrug-resistant acinetobacter baumannii. Antimicrob Agents Chemother 57(8):3568–3575. https://doi.org/10.1128/AAC.02109-12/ASSET/6EB53E77-993B-4C43-B8ED-68AED12DC8DE/ASSETS/GRAPHIC/ZAC9991019910006.JPEG

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  16. Jiang XQ, Mei XD, Feng D (2016) Air pollution and chronic airway diseases: what should people know and do? J Thorac Dis 8(1):E31–E40. https://doi.org/10.3978/J.ISSN.2072-1439.2015.11.50

    Article  PubMed  PubMed Central  Google Scholar 

  17. Jiang Y, Liu LS, Shen LP, Han ZF, Jian H, Liu JX, Xu L, Li HG, Tian JH, Mao ZJ (2016) Traditional Chinese Medicine treatment as maintenance therapy in advanced non-small-cell lung cancer: A randomized controlled trial. Complement Ther Med 24:55–62. https://doi.org/10.1016/J.CTIM.2015.12.006

    Article  PubMed  Google Scholar 

  18. Jiang Y, Wu LB, Shen LP, Zhang P, Jiang WJ, Tian JH, Liu LS (2016) Effect of traditional Chinese medicine treatment as maintenance therapy on regulating the serum concentration of sCTLA-4 in patients with advanced non-small-cell lung cancer and its relationship with prognosis. Zhonghua Zhong Liu Za Zhi [Chinese Journal of Oncology] 38(10):757–762. https://doi.org/10.3760/CMA.J.ISSN.0253-3766.2016.10.009

    Article  CAS  PubMed  Google Scholar 

  19. Khan I, Bahuguna A, Kumar P, Bajpai VK, Kang SC (2018) In vitro and in vivo antitumor potential of carvacrol nanoemulsion against human lung adenocarcinoma A549 cells via mitochondrial mediated apoptosis. Sci Rep 2017 8:1, 8(1), 1–15. https://doi.org/10.1038/s41598-017-18644-9

  20. Khani S, Keyhanfar F, Amani A (2015) Design and evaluation of oral nanoemulsion drug delivery system of mebudipine. https://Doi.Org/https://doi.org/10.3109/10717544.2015.1088597, 23(6), 2035–2043. https://doi.org/10.3109/10717544.2015.1088597

  21. Kim KH, Han CW, Yoon SH, Kim YS, Kim JI, Joo M, Choi JY (2016) The fruit hull of gleditsia sinensis enhances the Anti-Tumor effect of cis-diammine dichloridoplatinum II (Cisplatin). Evid-Based Complement Altern Medicine : ECAM. https://doi.org/10.1155/2016/7480971

  22. Kumar S, Sharma AK, Lalhlenmawia H, Kumar D (2021) Natural compounds targeting major signaling pathways in lung cancer. Target Cell Signal PathwS Lung Dis, 821–846. https://doi.org/10.1007/978-981-33-6827-9_37

  23. Lemjabbar-Alaoui H, Hassan OUI, Yang YW, Buchanan P (2015) Lung cancer: biology and treatment options. Biochem Biophys Acta 1856(2):189. https://doi.org/10.1016/J.BBCAN.2015.08.002

    Article  CAS  PubMed  Google Scholar 

  24. Li H, Ji Y, Zhang S, Gao Z, Hu C, Jiang R, Chen M, Li G, Zhang X (2019) Kangai Injection Combined with Platinum-based Chemotherapy for the Treatment of Stage III/IV Non-Small Cell Lung Cancer: A Meta-analysis and Systematic Review of 35 Randomized Controlled Trials. J Cancer 10(21):5283. https://doi.org/10.7150/JCA.31928

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  25. Li S, Fang C, Zhang J, Liu B, Wei Z, Fan X, Sui Z, Tan Q (2016) Catanionic lipid nanosystems improve pharmacokinetics and anti-lung cancer activity of curcumin. Nanomedicine: Nanotechnol, Biol Med, 12(6), 1567–1579. https://doi.org/10.1016/J.NANO.2016.02.007

  26. Liu G, Yang L, Chen G, Xu F, Yang F, Yu H, Li L, Dong X, Han J, Cao C, Qi J, Su J, Xu X, Li X, Li B (2021) A review on drug delivery system for tumor therapy. Front Pharmacol, 12. https://doi.org/10.3389/FPHAR.2021.735446

  27. Mahato R (2017) Nanoemulsion as targeted drug delivery system for cancer therapeutics. J Pharm Sci Pharmacol 3(2):83–97. https://doi.org/10.1166/JPSP.2017.1082

    Article  Google Scholar 

  28. Meghani N, Patel P, Kansara K, Ranjan S, Dasgupta N, Ramalingam C, Kumar A (2018) Formulation of vitamin D encapsulated cinnamon oil nanoemulsion: Its potential anti-cancerous activity in human alveolar carcinoma cells. Colloids Surf, B 166:349–357. https://doi.org/10.1016/J.COLSURFB.2018.03.041

    Article  CAS  Google Scholar 

  29. Panagopoulos N, Leivaditis V, Koletsis E, Prokakis C, Alexopoulos P, Baltayiannis N, Hatzimichalis A, Tsakiridis K, Zarogoulidis P, Zarogoulidis K, Katsikogiannis N, Kougioumtzi I, Machairiotis N, Tsiouda T, Kesisis G, Siminelakis S, Madesis A, Dougenis D (2014). Pancoast tumors: characteristics and preoperative assessment. J Thorac Dis, 6 Suppl 1(Suppl 1). https://doi.org/10.3978/J.ISSN.2072-1439.2013.12.29

  30. Pass HI, Carbone DP, Minna JD, Johnson DH, Scagliotti GV, Turrisi AT (2010) Principles and practice of lung cancer: the official reference text of the IASLC, 4e

    Google Scholar 

  31. Pérez-Herrero E, Fernández-Medarde A (2015) Advanced targeted therapies in cancer: Drug nano-carriers, the future of chemotherapy. Eur J Pharm Biopharmaceutics : Off J ArbSgemeinschaft Fur Pharm VerfahrStechnik e.V, 93, 52–79. https://doi.org/10.1016/J.EJPB.2015.03.018

  32. Pikor LA, Ramnarine VR, Lam S, Lam WL (2013) Genetic alterations defining NSCLC subtypes and their therapeutic implications. Lung Cancer (Amsterdam, Netherlands) 82(2):179–189. https://doi.org/10.1016/J.LUNGCAN.2013.07.025

    Article  PubMed  Google Scholar 

  33. Praveen Kumar G, Divya A, Kumar GP (2015) 272 Citation: Praveen Kumar G, Divya A (2015) Nanoemulsion based targeting in cancer therapeutics. Med Chem, an Open Access Journal 5(6):272–284. https://doi.org/10.4172/2161-0444.1000275

    Article  CAS  Google Scholar 

  34. Regassa H, Sourirajan A, Kumar V, Pandey S, Kumar D, Dev K (2022) A review of medicinal plants of the himalayas with Anti-Proliferative activity for the treatment of various cancers. Cancers 2022, Vol. 14, Page 3898, 14(16), 3898. https://doi.org/10.3390/CANCERS14163898

  35. Sun CY, Zhu Y, Li XF, Wang XQ, Tang LP, Su ZQ, Li CY, Zheng GJ, Feng B (2018). Scutellarin increases cisplatin-induced apoptosis and autophagy to overcome cisplatin resistance in non-small cell lung cancer via ERK/p53 and c-met/AKT signaling pathways. Front Pharmacol, 9 (FEB). https://doi.org/10.3389/FPHAR.2018.00092/FULL

  36. Sun D, Wei X, Xue X, Fang Z, Ren M, Lou H, Zhang X (2014) Enhanced oral absorption and therapeutic effect of acetylpuerarin based on D-α-tocopheryl polyethylene glycol 1000 succinate nanoemulsions. Int J Nanomed 9(1):3413–3423. https://doi.org/10.2147/IJN.S63777

    Article  CAS  Google Scholar 

  37. Tseng CY, Lin CH, Wu LY, Wang JS, Chung MC, Chang JF, Chao MW (2016) Potential combinational anti-cancer therapy in non-small cell lung cancer with traditional chinese medicine Sun-Bai-Pi extract and cisplatin. PloS One, 11(5). https://doi.org/10.1371/JOURNAL.PONE.0155469

  38. Wang Q, Jiao L, Wang S, Chen P, Bi L, Zhou D, Yao J, Li J, Wang L, Chen Z, Jia Y, Zhang Z, Shen W, Zhu W, Xu J, Gao Y, Xu L, Gong Y (2020) Adjuvant chemotherapy with chinese herbal medicine formulas versus placebo in patients with lung adenocarcinoma after radical surgery: a multicenter, randomized, Double-Blind, Placebo-Controlled Trial. Biol Proced Online, 22 (1). https://doi.org/10.1186/S12575-020-00117-5

  39. Wang SF, Wang Q, Jiao LJ, Huang YL, Garfield D, Zhang J, Xu L (2016) Astragalus-containing traditional Chinese Medicine, with and without prescription based on syndrome differentiation, combined with chemotherapy for advanced non-small-cell lung cancer: a systemic review and meta-analysis. Current Oncology (Toronto, Ont.), 23(3), e188–e195. https://doi.org/10.3747/CO.23.2920

  40. Zhang L, Li H, Zhang F, Wang S, Li G (2020) [CAR-T Immunotherapy and Non-small Cell Lung Cancer: Bottleneck and Dawn]. Zhongguo Fei Ai Za Zhi = Chinese Journal of Lung Cancer, 23(10), 916–920. https://doi.org/10.3779/J.ISSN.1009-3419.2020.103.10

  41. Zorzetto M, Ferrari S, Saracino L, Inghilleri S, Stella GM (2012) MET genetic lesions in non-small-cell lung cancer: pharmacological and clinical implications. Transl Lung Cancer Res 1(3):194–207. https://doi.org/10.3978/J.ISSN.2218-6751.2012.09.03

    Article  PubMed  PubMed Central  Google Scholar 

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Correspondence to Kundan Kumar Chaubey .

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Sinha, A. et al. (2023). Role of Nanoemulsion in Lung Cancer Treatment. In: Husen, A., Bachheti, R.K., Bachheti, A. (eds) Current Trends in Green Nano-emulsions. Smart Nanomaterials Technology. Springer, Singapore. https://doi.org/10.1007/978-981-99-5398-1_9

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