Abstract
Amphiphilic polymeric block copolymers find frequent applications due to their ability to deliver hydrophobic moieties to the physiological system. Their ability to solubilize water-insoluble drugs in the core has improved the pharmacokinetics and therapeutic potential of such drugs. The hydrophobic core of the polymeric micelles provides protection to degradation-prone drugs. The thermodynamically stable polymeric micelles can be engineered to liberate the loaded cargo in various fashions. Drug release patterns such as biphasic, stimuli-responsive, and physiological/pathological environment-responsive have been reported to improve the therapeutic potential in multiple diseases such as neurological disorders and cancer. The advantages of polymeric micelles over conventional drug delivery systems have been explained. The concepts behind engineering polymeric micelles with a particular drug-releasing phenomenon will be deliberated throughout the chapter. Additionally, the need for functionalization and the development of functionalized micelles in various diseases have been discussed in this chapter.
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The authors would like to acknowledge the research funding support by Department of Pharmaceuticals (DoP), Ministry of Chemicals and Fertilizers, Govt. of India to National Institute of Pharmaceutical Education and Research (NIPER) Hyderabad, INDIA.
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Vambhurkar, G., Jain, N., Srinivasarao, D.A., Famta, P., Singh, S.B., Srivastava, S. (2023). Drug Solubilization and Drug Release from Polymeric Micelles. In: Singh, S.K., Gulati, M., Mutalik, S., Dhanasekaran, M., Dua, K. (eds) Polymeric Micelles: Principles, Perspectives and Practices. Springer, Singapore. https://doi.org/10.1007/978-981-99-0361-0_5
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