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Advances in Polymer Optimization for Enhanced Drug Delivery

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Polymeric Micelles: Principles, Perspectives and Practices

Abstract

Nanocarriers are being used to deliver those active pharmaceutical ingredients (APIs) to the site of action that are toxic, biodegradable, and have less bioavailability. One type of nanocarrier that can meet the aforementioned criteria in the form of therapeutic formulations is polymeric micelles. They are revolutionary drug delivery nanocarriers that can be developed using various types of polymers to achieve specific features such as target specificity and controlled release for the drugs. There are different categories of polymers used to prepare such micelles such as graft polymers, diblock polymers, and triblock polymers. Diblock polymers such as polymer made up of poly(ε-caprolactone) [PCL] and poly(ethylene glycol) [PEG]; graft copolymers such as polymer made up of gelatin and hyaluronic acid; and triblock copolymers such as polymer made of polyethylene oxide PEO-b-PB-b-PEO (PB, polybutadiene; PEO, polyethylene oxide) are being employed in designing and develo** improved polymeric micelles which may respond better in the harsh inter/intracellular environments, for example: in changed ionic concentrations, in presence of several proteins and enzymes, pH changes and even at higher temperatures. In the present chapter, various types of polymers, which are used to prepare conventional, mucoadhesive, pH-sensitive and temperature-sensitive polymeric micelles, are discussed. The major focus of this chapter is to review various polymers used worldwide, which are used to obtain specialized micelles for specific applications, with desired characteristics for drug formulations.

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Authors and Affiliations

  1. Department of Biotechnology, JIIT Noida, Noida, UP, India

    Mayank Kashyap, Deepanshi Pathak, Shivani Gupta, Aanawi Tiwari, Mansi Sharma, Debdarshan Dutta, Radhika Sharma & R. Rachana

  2. Shobhaben Pratapbhai Patel School of Pharmacy and Technology Management, SVKM’s Narsee Monjee Institute of Management Studies (Deemed to be University), Mumbai, India

    Saritha Shetty

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  1. Mayank Kashyap
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  9. R. Rachana
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Editors and Affiliations

  1. School of Pharmaceutical Sciences, Lovely Professional University, Phagwara, Punjab, India

    Sachin Kumar Singh

  2. School of Pharmaceutical Sciences, Lovely Professional University, Jalandhar, Punjab, India

    Monica Gulati

  3. Department of Pharmaceutics, Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education, Manipal, Karnataka, India

    Srinivas Mutalik

  4. Harrison School of Pharmacy, Auburn University, Auburn, AL, USA

    Muralikrishnan Dhanasekaran

  5. Discipline of Pharmacy, University of Technology Sydney, Sydney, NSW, Australia

    Kamal Dua

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Kashyap, M. et al. (2023). Advances in Polymer Optimization for Enhanced Drug Delivery. In: Singh, S.K., Gulati, M., Mutalik, S., Dhanasekaran, M., Dua, K. (eds) Polymeric Micelles: Principles, Perspectives and Practices. Springer, Singapore. https://doi.org/10.1007/978-981-99-0361-0_2

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