Abstract
The polymeric micelles are the colloidal nanostructures composed of amphiphilic copolymers (having two functional blocks, namely hydrophobic and hydrophilic blocks), having a core-shell framework proven as if one of the most efficient carriers for drugs and nucleic acids. The three major pillars for preferring this versatile group of drug carriers are their capability to cater hydrophobic drug candidates, biocompatibility, and in vivo stability. Other functional advantages of these nanostructures are their capability to self-assemble and potential to respond to certain physical, chemical, and biological stimuli like temperature, light, pH, and enzyme. Several efforts have been made to change the polymeric micelles, focusing their longevity or stability and targeting strategies—regarded as important for passive targeting of drugs carried by or dissolved using the micelles. On the other hand, the structural modification in the micellar surface using a variety of ligands has been tried to focus selective targeting or the intracellular drug delivery, thus allowing these nanostructured micelles to respond to a variety of stimuli (both intrinsic and extrinsic) for the predetermined or triggered drug release at the target site. Therefore, these nano-carriers may be explored further for designing new generation drug carriers.
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Arora, V., Bhandari, D.D., Puri, R., Khatri, N., Dureja, H. (2023). Synthesis, Self-Assembly, and Functional Chemistry of Amphiphilic Block Copolymers. In: Singh, S.K., Gulati, M., Mutalik, S., Dhanasekaran, M., Dua, K. (eds) Polymeric Micelles: Principles, Perspectives and Practices. Springer, Singapore. https://doi.org/10.1007/978-981-99-0361-0_1
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