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An Overview of Immunosensors and Their Application

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Abstract

A key challenge in clinical healthcare is meeting the need to detect a disease at an early stage. Early and accurate diagnosis not only cuts the treatment cost but can also reduce disease burden, mortality rate, and social inequalities. Therefore, researchers are always searching for a method that allows rapid, simple, sensitive, selective, and cost-effective detection of the target biomarker (peptides, proteins, or nucleic acid). Immunosensors are one such point-of-care diagnostic device that can play an important role in almost all clinical healthcare fields. They are a promising alternative to the traditional immunoassays and state-of-the-art affinity sensors to diagnose clinically important analytes/antigens due to their high affinity, versatility, compact size, fast response time, minimum sample processing, and the measurements’ reproducibility. For many decades now, significant advancement has been made in the immunosensor field in which the use of nanomaterials for increased sensitivity, multiplexing, or microfluidic-based devices may have the potential for promising use in clinical analysis. This chapter will provide an overview of the currently available immunosensor technology, its types that are currently being developed, and the limitations and future directions of immunosensor technology for the clinical laboratory.

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Author notes

  1. Anil Kumar Gupta and Sambhavi Animesh contributed equally to this work.

Authors and Affiliations

  1. Laboratory Oncology Unit, Dr. B.R.A.I.R.C.H., All India Institute of Medical Sciences, Delhi, India

    Anil Kumar Gupta

  2. Cancer Science Institute of Singapore, Centre for Translational Medicine, National University of Singapore, Singapore, Singapore

    Sambhavi Animesh

  3. Department of Microbiology, Central University of Punjab, Bathinda, India

    Amit Singh

Authors
  1. Anil Kumar Gupta
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  2. Sambhavi Animesh
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  3. Amit Singh
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Corresponding author

Correspondence to Amit Singh .

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Editors and Affiliations

  1. Department of Chemical Engineering, Chungbuk National University, Cheongju, Korea (Republic of)

    Prasun Kumar

  2. Department of Zoology, Berhampur University, Odisha, India

    Sandip Kumar Dash

  3. Department of Life Sciences SBSR, Sharda University, Greater Noida, India

    Subhasree Ray

  4. MNR Foundation for Research & Innovations MNR Medical College & Hospital, Sangareddy, Telangana, India

    Shahila Parween

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Gupta, A.K., Animesh, S., Singh, A. (2023). An Overview of Immunosensors and Their Application. In: Kumar, P., Dash, S.K., Ray, S., Parween, S. (eds) Biomaterials-Based Sensors. Springer, Singapore. https://doi.org/10.1007/978-981-19-8501-0_8

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