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Metabolic Rewiring and Cultivation Optimization for Photosynthetic Biofuel Production in Cyanobacteria

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Bio-Clean Energy Technologies: Volume 1

Part of the book series: Clean Energy Production Technologies ((CEPT))

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Abstract

The depletion and use of fossil resources together with global environmental concerns related to CO2 emissions require a transition toward carbon-neutral, sustainable bioenergy. Photosynthetic organisms have great potential as cell factories for directly converting CO2 into a broad range of value-added biochemicals, especially biofuels. Cyanobacteria are particularly attractive as platforms for bio-production, due to relatively fast growth rate, genetic tractability, and low nutrient requirements. Synthetic biology and metabolic engineering pave the way to develop cyanobacteria as green chassis for production of various biofuels, including, e.g., hydrogen, ethanol, butanol, and isoprene. However, engineered cyanobacteria show relatively low productivity compared with model heterotrophic microorganisms. Significant advances of biofuel production using cyanobacterial chassis are expected by implementing recently developed system biology tools as well as optimized cultivation systems with newly developed photobioreactors.

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Acknowledgments

This work was supported by the Swedish Energy Agency (project numbers P46607-1 and 38334-3), the NordForskNCoE program “NordAqua” (project number 82845), and the Svenska Forskningsrådet Formas (project number 2016-01325).

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Authors and Affiliations

  1. Department of Chemistry-Ångström, Uppsala University, Uppsala, Sweden

    Hao **e, Kateryna Kukil, Pia Lindberg & Peter Lindblad

  2. Science for Life Laboratory, KTH - Royal Institute of Technology, Stockholm, Sweden

    Rui Miao

  3. Department of Protein Science, KTH - Royal Institute of Technology, Stockholm, Sweden

    Rui Miao

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  1. Environmental Microbiology Laboratory, CSIR-Indian Institute of Toxicology Research, Lucknow, Uttar Pradesh, India

    Pankaj Chowdhary

  2. Department of Biotechnology, Birla Institute of Technology and Science, Pilani, Dubai Campus, Dubai, United Arab Emirates

    Namita Khanna

  3. Department of Life Sciences, School of Basic Sciences and Research, Sharda University, Greater Noida, India

    Soumya Pandit

  4. Department of Microbiology, Babasaheb Bhimrao Ambedkar University, Lucknow, Uttar Pradesh, India

    Rajesh Kumar

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**e, H., Kukil, K., Lindberg, P., Miao, R., Lindblad, P. (2022). Metabolic Rewiring and Cultivation Optimization for Photosynthetic Biofuel Production in Cyanobacteria. In: Chowdhary, P., Khanna, N., Pandit, S., Kumar, R. (eds) Bio-Clean Energy Technologies: Volume 1. Clean Energy Production Technologies. Springer, Singapore. https://doi.org/10.1007/978-981-16-8090-8_3

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