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The Skin Metagenomes: Insights into Involvement of Microbes in Diseases

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Metagenomics: Techniques, Applications, Challenges and Opportunities

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Abstract

The skin is the first barrier of the body and is also a pitch for various microbes. Earlier, research on the skin microbiology was primarily influenced by culture-based techniques. However, now the scenario has changed. Metagenomics has emerged as a more efficient tool for obtaining comprehensive information and understanding of the microbiome of the skin. Metagenomics comprises techniques of high-throughput sequencing, gene-prediction, sequencing of amplicon-based assays, metatranscriptomics and shotgun metagenomics. The sequence data is studied further using statistical as well as comparative analyses. These analyses provide an understanding of the skin microbiome diversity, both functionally and metabolically. Thus, better information of the mechanism of how microbial population of the skin interacts with one other and also with the host could lead to the development of significant clinical treatments as to how we can control those microbial interactions for preventing as well as in curing of various dermatological diseases.

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Author information

Authors and Affiliations

  1. School of Biotechnology, Shri Mata Vaishno Devi University, Katra, Jammu and Kashmir, India

    Jyotsana Sharma

  2. Ancient DNA Laboratory, Birbal Sahni Institute of Palaeosciences, Lucknow, Uttar Pradesh, India

    Varun Sharma & Indu Sharma

Authors
  1. Jyotsana Sharma
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  2. Varun Sharma
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  3. Indu Sharma
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Editor information

Editors and Affiliations

  1. School of Bioengineering and Biosciences, Lovely Professional University, Jalandhar, Punjab, India

    Reena Singh Chopra

  2. School of Bioengineering and Biosciences, Lovely Professional University, Jalandhar, Punjab, India

    Chirag Chopra

  3. School of Bioengineering and Biosciences, Lovely Professional University, Jalandhar, Punjab, India

    Neeta Raj Sharma

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Sharma, J., Sharma, V., Sharma, I. (2020). The Skin Metagenomes: Insights into Involvement of Microbes in Diseases. In: Chopra, R.S., Chopra, C., Sharma, N.R. (eds) Metagenomics: Techniques, Applications, Challenges and Opportunities. Springer, Singapore. https://doi.org/10.1007/978-981-15-6529-8_12

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