Artificial Liver and Liver Transplantation

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Artificial Liver

Abstract

The artificial liver support system (ALSS) was first applied to treat acute liver failure in the 1970s with an attempt to replace the detoxification functions of the liver. In the past five decades, a variety of different types of ALSS have been developed to bridge patients with liver failure (LF) to liver transplantation or to support the failing liver temporarily, until it is able to regenerate. It has been demonstrated that some types of ALSS, such as plasma exchange (PE) and plasma bilirubin adsorption (PBA), are able to remove toxic substances, improve coagulopathy, and prevent bleeding. How to take the application of ALSS to bridge LF patients to liver transplantation has become a challenge? In this chapter, we summarized the role of ALSS played in perioperative period of liver transplantation patients.

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References

  1. Park MS, Lee KW, Suh SW, et al. Living-donor liver transplantation associated with higher incidence of hepatocellular carcinoma recurrence than deceased-donor liver transplantation. Transplantation. 2014;97:71–7.

    Article  Google Scholar 

  2. Watashi K, Sluder A, Daito T, et al. Cyclosporin A and its analogs inhibit hepatitis B virus entry into cultured hepatocytes through targeting a membrane transporter, sodium taurocholate cotransporting polypeptide (NTCP). Hepatology. 2014;59:1726–37.

    Article  CAS  Google Scholar 

  3. Clavien PA, Lesurtel M, Bossuyt PM, et al. Recommendations for liver transplantation for hepatocellular carcinoma: an international consensus conference report. Lancet Oncol. 2012;13:e11–22.

    Article  Google Scholar 

  4. Gosalia AJ, Martin P, Jones PD. Advances and future directions in the treatment of hepatocellular carcinoma. Gastroenterol Hepatol. 2017;13:398–410.

    Google Scholar 

  5. Bhangui P, Vibert E, Ma**o P. Intention-to-treat analysis of liver transplantation for hepatocellular carcinoma: living versus deceased donor transplantation. Hepatology. 2011;53:1570–9.

    Article  Google Scholar 

  6. Hammad A, Kaido T, Ogawa K, et al. Liver transplantation for advanced hepatocellular carcinoma in patients with child-Pugh A and B. Surg Today. 2016;46:248–54.

    Article  CAS  Google Scholar 

  7. Ninomiya M, Shirabe K, Facciuto ME, et al. Comparative study of living and deceased donor liver transplantation as a treatment for hepatocellular carcinoma. J Am Coll Surg. 2015;220:297–304.

    Article  Google Scholar 

  8. Le Moine O, Louis O, Demols A, et al. Cold liver ischemia-reperfusion injury critically depends on liver T cells and is improved by donor pretreatment with interleukin 10 in mice. Hepatology. 2000;31:1266–74.

    Article  Google Scholar 

  9. Fukazawa K, Lang JD. Role of nitric oxide in liver transplantation: should it be routinely used? World J Hepatol. 2016;8:1489–96.

    Article  Google Scholar 

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Chen, D., Shen, T., Wu, J. (2021). Artificial Liver and Liver Transplantation. In: Li, L. (eds) Artificial Liver. Springer, Singapore. https://doi.org/10.1007/978-981-15-5984-6_20

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  • DOI: https://doi.org/10.1007/978-981-15-5984-6_20

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  • Publisher Name: Springer, Singapore

  • Print ISBN: 978-981-15-5983-9

  • Online ISBN: 978-981-15-5984-6

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