Abstract
Cancer is a devastating disease worldwide and is characterized by elevated reactive oxygen species (ROS). ROS overproduction has been identified in various cancers which serves numerous roles in cancer progression and tumorigenesis. Microtubule targeting agents can be natural or synthetic small molecules which can target cellular microtubule dynamics. Microtubule targeting agents are widely studied and are used in clinical interventions as well for different cancer therapeutics. Microtubule dynamics and ROS both are interrelated in caner formation and progression ROS can activate pro-tumorigenic signaling to enhance genetic instability, DNA damage, cell proliferation, metastasis, angiogenesis, and tumor development. However, counter intuitively ROS can also promote antitumorigenic property, which can initiate oxidative stress-mediated cell death. Many cellular microtubule targeting chemotherapeutic drugs can produce ROS to promote cancer cell death by primarily through apoptosis and autophagy. This book chapter discusses about how microtubule targeting agents showing anticancer properties with the generation of ROS-mediated apoptosis by activating different cellular signaling pathways.
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Das, A., Paul, S., Chakrabarty, S., Dasgupta, M., Chakrabarti, G. (2021). Microtubule Targeting Agents Induce ROS–Mediated Apoptosis in Cancer. In: Chakraborti, S., Ray, B.K., Roychowdhury, S. (eds) Handbook of Oxidative Stress in Cancer: Mechanistic Aspects. Springer, Singapore. https://doi.org/10.1007/978-981-15-4501-6_46-1
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