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Modulators of ROS/NF-κB Signaling in Cancer Therapy

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Handbook of Oxidative Stress in Cancer: Mechanistic Aspects

Abstract

Oxidative stress regulates NF-κB signaling pathway and induces the transcription of genes related to apoptosis and cell proliferation. Due to its crucial role in the pathogenesis of diseases caused by oxidative damage, it is believed that NF-κB is a promising target for treatment of diseases resulting from ROS, like cancer. There is a plethora of bioactive natural compounds, isolated from plants and organisms that exhibit anti-tumor activity against various types of cancer through modulation of ROS/NF-κB signaling. Some of these compounds belong to large natural product families like terpenoids, alkaloids, steroids and saponins. The aim of this chapter is to provide an overview of small molecule modulators of ROS/NF-κB signaling, their anticancer properties, and their future perspectives for cancer therapy.

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Authors and Affiliations

  1. Department of Chemistry, Aristotle University of Thessaloniki, Thessaloniki, Greece

    Maria Voura, Eleni Sflakidou & Vasiliki Sarli

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  1. Maria Voura
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  2. Eleni Sflakidou
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  3. Vasiliki Sarli
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Correspondence to Vasiliki Sarli .

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Editors and Affiliations

  1. Department of Biochemistry and Biophysic, University of Kalyani Department of Biochemistry and Biophysic, Kalyani, West Bengal, India

    Sajal Chakraborti

  2. Dept of Veterinary Pathobiology, University of Missouri, College Vet, Columbia, MO, USA

    Bimal K Ray

  3. Saroj Gupta Cancer Centre & Research Ins, Kolkata, India

    Sushanta Roychowdhury

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Voura, M., Sflakidou, E., Sarli, V. (2021). Modulators of ROS/NF-κB Signaling in Cancer Therapy. In: Chakraborti, S., Ray, B.K., Roychowdhury, S. (eds) Handbook of Oxidative Stress in Cancer: Mechanistic Aspects. Springer, Singapore. https://doi.org/10.1007/978-981-15-4501-6_135-1

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  • DOI: https://doi.org/10.1007/978-981-15-4501-6_135-1

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  • Print ISBN: 978-981-15-4501-6

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