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VEGFR and PDGFR Targeting in Pancreatic Cancer

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Role of Tyrosine Kinases in Gastrointestinal Malignancies

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Abstract

Numerous studies have confirmed that angiogenesis acts as a momentous process in pancreatic cancer (PC) developmental stages in tumor growth, proliferation, differentiation, and metastasis. Proangiogenic factor overexpression such as fibroblast growth factor (FGF), tumor necrosis factor (TNF), epidermal growth factor (EGF), vascular endothelial growth factor (VEGF), and platelet-derived growth factor (PDGF) initiates progression of angiogenesis in the tumor cells. Among these VEGF and PDGFR have been confirmed as strong angiogenic factors. Overexpression of these factors has an imperative function in each step of angiogenesis development during tumor progression, recurrence, and fewer prognoses in pancreatic carcinomas. This chapter covers elementary biology of VEGF and PDGFR and their expression as prognostic biomarkers in pancreatic cancer. Overexpression of VEGF–PDGFR-mediated signaling pathways associated with pancreatic cancer metastasis and accumulating diverse therapeutic targets of VEGF and PDGFR complex are discussed.

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Authors and Affiliations

  1. Department of Bioscience and Biotechnology, Banasthali University, Banasthali, Rajasthan, India

    Gowru Srivani & Afroz Alam

  2. Department of Hematology and Medical Oncology, Winship Cancer Institute, Emory University, Atlanta, GA, USA

    Shipra Reddy Bethi

  3. Department of Biotechnology, Jawaharlal Nehru Technical University, Hyderabad, Telangana, India

    Sheik Aliya

  4. Department of Hematology and Medical Oncology, School of Medicine, Winship Cancer Institute, Emory University, Atlanta, GA, USA

    Ganji Purnachandra Nagaraju

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  1. Gowru Srivani
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  2. Shipra Reddy Bethi
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Correspondence to Ganji Purnachandra Nagaraju .

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  1. Department of Hematology and Medical Oncology, School of Medicine, Winship Cancer Institute, Emory University, Atlanta, GA, USA

    Ganji Purnachandra Nagaraju

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Srivani, G., Bethi, S.R., Aliya, S., Alam, A., Nagaraju, G.P. (2018). VEGFR and PDGFR Targeting in Pancreatic Cancer. In: Nagaraju, G. (eds) Role of Tyrosine Kinases in Gastrointestinal Malignancies. Springer, Singapore. https://doi.org/10.1007/978-981-13-1486-5_7

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