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Unexplained Infertility: Treatment Strategy for Unexplained Infertility

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Treatment Strategy for Unexplained Infertility and Recurrent Miscarriage

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Abstract

The candidate causes of unexplained infertility are (1) oviduct dysfunction with tubal patency, (2) fertilization failure and (3) implantation failure without an organic lesion. At any rate, undetectable causes of infertility inhibit the processes of sperm-egg encounter or implantation. Thus, patients with unexplained infertility cannot benefit from general infertility treatment, including timed intercourse or intrauterine insemination. Assisted reproductive technology including in vitro fertilization can overcome tubal dysfunction and fertilization failure, but not recurrent implantation failure (RIF). As regards RIF, hysteroscopy and blood tests for immunological abnormality and recurrent miscarriage should be performed as clinically practicable implantation testing. The treatment of RIF is the remedy of detected causes. If there is no cause of implantation failure, treatment approaches include endometrial injury during luteal phase, systemic single-dose G-CSF injection at embryo transfer, a vitrified-warmed single blastocyst transfer with assisted hatching and hyaluronan-enriched medium.

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Authors and Affiliations

  1. Center for Reproductive Medicine and Implantation Research, Sugiyama Clinic Shinjuku, Tokyo, Japan

    Keiji Kuroda

  2. Department of Obstetrics and Gynaecology, Faculty of Medicine, Juntendo University, Tokyo, Japan

    Keiji Kuroda & Asako Ochiai

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  1. Keiji Kuroda
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  2. Asako Ochiai
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Correspondence to Keiji Kuroda .

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Editors and Affiliations

  1. Center for Reproductive Medicine and Implantation Research, Sugiyama Clinic Shinjuku, Tokyo, Japan

    Keiji Kuroda

  2. Department of Obstetrics and Gynaecology, Faculty of Medicine, Juntendo University, Tokyo, Japan

    Jan J. Brosens

  3. The Division of Biomedical Sciences, Clinical Science Research Laboratories Warwick Medical School, Coventry, United Kingdom

    Siobhan Quenby

  4. Department of Obstetrics and Gynaecology, Juntendo University, Tokyo, Japan

    Satoru Takeda

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Kuroda, K., Ochiai, A. (2018). Unexplained Infertility: Treatment Strategy for Unexplained Infertility. In: Kuroda, K., Brosens, J., Quenby, S., Takeda, S. (eds) Treatment Strategy for Unexplained Infertility and Recurrent Miscarriage. Springer, Singapore. https://doi.org/10.1007/978-981-10-8690-8_6

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  • DOI: https://doi.org/10.1007/978-981-10-8690-8_6

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